Human Heart Mast Cells in Anaphylaxis and Cardiovascular Disease

1995 ◽  
Vol 107 (1-3) ◽  
pp. 72-75 ◽  
Author(s):  
Gianni Marone ◽  
Vincenzo Patella ◽  
Gennaro de Crescenzo ◽  
Arturo Genovese ◽  
Monika Adt
Keyword(s):  
Cardiovascular Disease ◽  
Mast Cells ◽  
Human Heart

scholarly journals Mast Cells in Cardiovascular Disease: From Bench to Bedside

2019 ◽  
Vol 20 (14) ◽  
pp. 3395 ◽  
Author(s):  
Hermans ◽  
Lennep ◽  
van Daele ◽  
Bot
Keyword(s):  
Cardiovascular Disease ◽  
Mast Cells ◽  
Animal Studies ◽  
Intraplaque Hemorrhage ◽  
Hematological Disease ◽  
Plaque Instability ◽  
Clonal Proliferation ◽  
Progression Of Atherosclerosis

Mast cells are pluripotent leukocytes that reside in the mucosa and connective tissue. Recent studies show an increased prevalence of cardiovascular disease among patients with mastocytosis, which is a hematological disease that is characterized by the accumulation of mast cells due to clonal proliferation. This association suggests an important role for mast cells in cardiovascular disease. Indeed, the evidence establishing the contribution of mast cells to the development and progression of atherosclerosis is continually increasing. Mast cells may contribute to plaque formation by stimulating the formation of foam cells and causing a pro-inflammatory micro-environment. In addition, these cells are able to promote plaque instability by neo-vessel formation and also by inducing intraplaque hemorrhage. Furthermore, mast cells appear to stimulate the formation of fibrosis after a cardiac infarction. In this review, the available data on the role of mast cells in cardiovascular disease are summarized, containing both in vitro research and animal studies, followed by a discussion of human data on the association between cardiovascular morbidity and diseases in which mast cells are important: Kounis syndrome, mastocytosis and allergy.

What Are Human Heart Mast Cells For?

2015 ◽  
pp. 171-186 ◽  
Author(s):  
Vincenzo Patella ◽  
Arturo Genovese ◽  
Gianni Marone
Keyword(s):  
Mast Cells ◽  
Human Heart

scholarly journals Bacterial Immunoglobulin Superantigen Proteins A and L Activate Human Heart Mast Cells by Interacting with Immunoglobulin E

2000 ◽  
Vol 68 (10) ◽  
pp. 5517-5524 ◽  
Author(s):  
Arturo Genovese ◽  
Jean-Pierre Bouvet ◽  
Giovanni Florio ◽  
Bärbel Lamparter-Schummert ◽  
Lars Björck ◽  
...  
Keyword(s):  
Mast Cells ◽  
Human Heart ◽  
Immunoglobulin E ◽  
Protein A ◽  
Surface Protein ◽  
Heart Tissue ◽  
Protein L ◽  
Cysteinyl Leukotriene ◽  
Proinflammatory Mediators

ABSTRACT Human heart mast cells (HHMC) have been identified in heart tissue, perivascularly, and in the intima of coronary arteries. In vitro activation of isolated HHMC induces the release of vasoactive and proinflammatory mediators (histamine, tryptase, and cysteinyl leukotriene C4 [LTC4]). We investigated the effects of several bacterial proteins on HHMC activation in vitro. HHMC released histamine, tryptase, and LTC4 in response toStaphylococcus aureus Cowan 1 and the immunoglobulin (Ig)-binding protein A, but not to S. aureus Wood 46, which does not synthesize protein A. The effect of protein A was inhibited by preincubation with monoclonal IgM VH3+. Some strains of Peptostreptococcus magnus express an Ig light chain-binding surface protein called protein L. Such bacteria and soluble protein L stimulated the release of preformed and newly synthesized mediators from HHMC. Preincubation of HHMC with either protein A or protein L resulted in complete cross-desensitization to a subsequent challenge with the heterologous stimulus or anti-IgE. Monoclonal IgE (κ chains) blocked protein L-induced release, whereas IgE (λ chains) had no effect. Streptococcal protein G, formyl-containing tripeptide, and pepstatin A did not activate HHMC. Bacterial products protein A and protein L and intact bacteria (S. aureus and P. magnus) activate HHMC by acting as Ig superantigens.

Immunologic and non-immunologic release of histamine and tryptase from human heart mast cells

1995 ◽  
Vol 44 (S1) ◽  
pp. S22-S23 ◽  
Author(s):  
V. Patella ◽  
I. Marinò ◽  
B. Lamparter ◽  
A. Genovese ◽  
M. Adt ◽  
...  
Keyword(s):  
Mast Cells ◽  
Human Heart

Eosinophil Granule Proteins Are Selective Activators of Human Heart Mast Cells

1997 ◽  
Vol 113 (1-3) ◽  
pp. 200-202 ◽  
Author(s):  
Vincenzo Patella ◽  
Gennaro de Crescenzo ◽  
Isabella Marinò ◽  
Arturo Genovese ◽  
Monika Adt ◽  
...  
Keyword(s):  
Mast Cells ◽  
Human Heart ◽  
Eosinophil Granule Proteins ◽  
Granule Proteins ◽  
Eosinophil Granule

Morphologic and morphometric analysis of the mast cells from human heart biopsies

1987 ◽  
Vol 20 (3-4) ◽  
pp. 288-290 ◽  
Author(s):  
K. Rydzyński ◽  
H. Dalen ◽  
T. Saetersdal ◽  
H. Engedal
Keyword(s):  
Mast Cells ◽  
Morphometric Analysis ◽  
Human Heart

scholarly journals The Healthy Heart: Lessons from Nature's Elite Athletes

Physiology ◽  
2015 ◽  
Vol 30 (5) ◽  
pp. 349-357 ◽  
Author(s):  
Terrie M. Williams ◽  
Penni Bengtson ◽  
Diana L. Steller ◽  
Donald A. Croll ◽  
Randall W. Davis
Keyword(s):  
Cardiovascular Disease ◽  
Body Size ◽  
Daily Activity ◽  
Human Heart ◽  
Elite Athletes ◽  
Mammalian Species ◽  
Activity Patterns ◽  
Wild Mammals ◽  
Daily Activity Patterns ◽  
Relative Vulnerability

The incidence of cardiovascular disease in humans is more than three times that of many wild and domestic mammals despite nearly identical heart morphologies and responses to exercise. A survey of mammalian species from 0.002-kg shrews to 43,000-kg whales shows that the human heart is more dog-like than cat-like and that neither body size nor longevity accounts for the relative vulnerability to cardiovascular disease. Rather, a major difference is daily activity patterns, which may underlie the comparatively healthy hearts of wild mammals.

scholarly journals P566Cardiac mast cells exist in all chambers of the failing human heart and may contribute to human heart failure

2017 ◽  
Vol 38 (suppl_1) ◽  
Author(s):  
M. Sandstedt ◽  
M. Jansson ◽  
K. Vukusic ◽  
M. Jonsson ◽  
A. Oldfors ◽  
...  
Keyword(s):  
Heart Failure ◽  
Mast Cells ◽  
Human Heart ◽  
Human Heart Failure

Human Heart Mast Cells: A Definitive Case of Mast Cell Heterogeneity

1995 ◽  
Vol 106 (4) ◽  
pp. 386-393 ◽  
Author(s):  
Vincenzo Patella ◽  
Gennaro de Crescenzo ◽  
Anna Ciccarelli ◽  
Isabella Marinò ◽  
Monika Adt ◽  
...  
Keyword(s):  
Mast Cell ◽  
Mast Cells ◽  
Human Heart ◽  
Cell Heterogeneity ◽  
Definitive Case ◽  
Mast Cell Heterogeneity

Human Heart Mast Cells: Immunological Characterization In Situ and In Vitro

2000 ◽  
pp. 455-477 ◽  
Author(s):  
Marone Gianni ◽  
Gennaro De Crescenzo ◽  
Vincenzo Patella ◽  
Francescopaolo Granata ◽  
Arturo Genovese ◽  
...  
Keyword(s):  
Mast Cells ◽  
Human Heart ◽  
Immunological Characterization
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