Immunologic and non-immunologic release of histamine and tryptase from human heart mast cells

1995 ◽  
Vol 44 (S1) ◽  
pp. S22-S23 ◽  
Author(s):  
V. Patella ◽  
I. Marinò ◽  
B. Lamparter ◽  
A. Genovese ◽  
M. Adt ◽  
...  
Keyword(s):  
Mast Cells ◽  
Human Heart

What Are Human Heart Mast Cells For?

2015 ◽  
pp. 171-186 ◽  
Author(s):  
Vincenzo Patella ◽  
Arturo Genovese ◽  
Gianni Marone
Keyword(s):  
Mast Cells ◽  
Human Heart

scholarly journals Bacterial Immunoglobulin Superantigen Proteins A and L Activate Human Heart Mast Cells by Interacting with Immunoglobulin E

2000 ◽  
Vol 68 (10) ◽  
pp. 5517-5524 ◽  
Author(s):  
Arturo Genovese ◽  
Jean-Pierre Bouvet ◽  
Giovanni Florio ◽  
Bärbel Lamparter-Schummert ◽  
Lars Björck ◽  
...  
Keyword(s):  
Mast Cells ◽  
Human Heart ◽  
Immunoglobulin E ◽  
Protein A ◽  
Surface Protein ◽  
Heart Tissue ◽  
Protein L ◽  
Cysteinyl Leukotriene ◽  
Proinflammatory Mediators

ABSTRACT Human heart mast cells (HHMC) have been identified in heart tissue, perivascularly, and in the intima of coronary arteries. In vitro activation of isolated HHMC induces the release of vasoactive and proinflammatory mediators (histamine, tryptase, and cysteinyl leukotriene C4 [LTC4]). We investigated the effects of several bacterial proteins on HHMC activation in vitro. HHMC released histamine, tryptase, and LTC4 in response toStaphylococcus aureus Cowan 1 and the immunoglobulin (Ig)-binding protein A, but not to S. aureus Wood 46, which does not synthesize protein A. The effect of protein A was inhibited by preincubation with monoclonal IgM VH3+. Some strains of Peptostreptococcus magnus express an Ig light chain-binding surface protein called protein L. Such bacteria and soluble protein L stimulated the release of preformed and newly synthesized mediators from HHMC. Preincubation of HHMC with either protein A or protein L resulted in complete cross-desensitization to a subsequent challenge with the heterologous stimulus or anti-IgE. Monoclonal IgE (κ chains) blocked protein L-induced release, whereas IgE (λ chains) had no effect. Streptococcal protein G, formyl-containing tripeptide, and pepstatin A did not activate HHMC. Bacterial products protein A and protein L and intact bacteria (S. aureus and P. magnus) activate HHMC by acting as Ig superantigens.

Eosinophil Granule Proteins Are Selective Activators of Human Heart Mast Cells

1997 ◽  
Vol 113 (1-3) ◽  
pp. 200-202 ◽  
Author(s):  
Vincenzo Patella ◽  
Gennaro de Crescenzo ◽  
Isabella Marinò ◽  
Arturo Genovese ◽  
Monika Adt ◽  
...  
Keyword(s):  
Mast Cells ◽  
Human Heart ◽  
Eosinophil Granule Proteins ◽  
Granule Proteins ◽  
Eosinophil Granule

Human Heart Mast Cells in Anaphylaxis and Cardiovascular Disease

1995 ◽  
Vol 107 (1-3) ◽  
pp. 72-75 ◽  
Author(s):  
Gianni Marone ◽  
Vincenzo Patella ◽  
Gennaro de Crescenzo ◽  
Arturo Genovese ◽  
Monika Adt
Keyword(s):  
Cardiovascular Disease ◽  
Mast Cells ◽  
Human Heart

Morphologic and morphometric analysis of the mast cells from human heart biopsies

1987 ◽  
Vol 20 (3-4) ◽  
pp. 288-290 ◽  
Author(s):  
K. Rydzyński ◽  
H. Dalen ◽  
T. Saetersdal ◽  
H. Engedal
Keyword(s):  
Mast Cells ◽  
Morphometric Analysis ◽  
Human Heart

scholarly journals P566Cardiac mast cells exist in all chambers of the failing human heart and may contribute to human heart failure

2017 ◽  
Vol 38 (suppl_1) ◽  
Author(s):  
M. Sandstedt ◽  
M. Jansson ◽  
K. Vukusic ◽  
M. Jonsson ◽  
A. Oldfors ◽  
...  
Keyword(s):  
Heart Failure ◽  
Mast Cells ◽  
Human Heart ◽  
Human Heart Failure

Human Heart Mast Cells: A Definitive Case of Mast Cell Heterogeneity

1995 ◽  
Vol 106 (4) ◽  
pp. 386-393 ◽  
Author(s):  
Vincenzo Patella ◽  
Gennaro de Crescenzo ◽  
Anna Ciccarelli ◽  
Isabella Marinò ◽  
Monika Adt ◽  
...  
Keyword(s):  
Mast Cell ◽  
Mast Cells ◽  
Human Heart ◽  
Cell Heterogeneity ◽  
Definitive Case ◽  
Mast Cell Heterogeneity

Human Heart Mast Cells: Immunological Characterization In Situ and In Vitro

2000 ◽  
pp. 455-477 ◽  
Author(s):  
Marone Gianni ◽  
Gennaro De Crescenzo ◽  
Vincenzo Patella ◽  
Francescopaolo Granata ◽  
Arturo Genovese ◽  
...  
Keyword(s):  
Mast Cells ◽  
Human Heart ◽  
Immunological Characterization

Distribution of mast cells in human heart auricles and correlation with tissue histamine

1988 ◽  
Vol 23 (3-4) ◽  
pp. 273-275 ◽  
Author(s):  
K. Rydzyński ◽  
B. Kolago ◽  
J. Zasŀonka ◽  
W. Kuroczyński
Keyword(s):  
Mast Cells ◽  
Human Heart ◽  
Tissue Histamine

Immunological characterization and functional importance of human heart mast cells

1995 ◽  
Vol 31 (1) ◽  
pp. 1-18 ◽  
Author(s):  
Gianni Marone ◽  
Gennaro de Crescenzo ◽  
Monika Adt ◽  
Vincenzo Patella ◽  
Eloisa Arbustini ◽  
...  
Keyword(s):  
Mast Cells ◽  
Human Heart ◽  
Functional Importance ◽  
Immunological Characterization
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