Homology of Two cDNAs Coding for Birch Pollen Allergens with Calmodulin: Protein-Bound Ca2+ Affects the IgE-Binding Capacity

1992 ◽  
Vol 99 (2-4) ◽  
pp. 380-381 ◽  
Author(s):  
Susanne Seiberler ◽  
Otto Scheiner ◽  
Dietrich Kraft ◽  
Rudolf Valenta
Keyword(s):  
Binding Capacity ◽  
Birch Pollen ◽  
Pollen Allergens ◽  
Ige Binding

IgE-binding capacity of recombinant timothy grass (Phleum pratense) pollen allergens

1994 ◽  
Vol 94 (1) ◽  
pp. 88-94 ◽  
Author(s):  
Sylvia Laffer ◽  
Susanne Vrtala ◽  
Michael Duchêne ◽  
Ronald van Ree ◽  
Dietrich Kraft ◽  
...  
Keyword(s):  
Binding Capacity ◽  
Phleum Pratense ◽  
Pollen Allergens ◽  
Timothy Grass ◽  
Ige Binding

Heterogeneity in the Polyclonal T Cell Response to Birch Pollen Allergens

1997 ◽  
Vol 114 (3) ◽  
pp. 272-277 ◽  
Author(s):  
D. Dormann ◽  
E. Montermann ◽  
L. Klimek ◽  
B. Weber ◽  
C. Ebner ◽  
...  
Keyword(s):  
T Cell ◽  
Cell Response ◽  
Birch Pollen ◽  
T Cell Response ◽  
Pollen Allergens

Constructing a hybrid molecule with low capacity of IgE binding from Chenopodium album pollen allergens

2012 ◽  
Vol 144 (1-2) ◽  
pp. 67-77 ◽  
Author(s):  
Hamid Reza Nouri ◽  
Abdolreza Varasteh ◽  
Fatemeh Vahedi ◽  
Jamshidkhan Chamani ◽  
Danial Afsharzadeh ◽  
...  
Keyword(s):  
Chenopodium Album ◽  
Hybrid Molecule ◽  
Pollen Allergens ◽  
Ige Binding

scholarly journals Allergenic Characterization of New Mutant Forms of Pru p 3 as New Immunotherapy Vaccines

2013 ◽  
Vol 2013 ◽  
pp. 1-12 ◽  
Author(s):  
C. Gómez-Casado ◽  
M. Garrido-Arandia ◽  
P. Gamboa ◽  
N. Blanca-López ◽  
G. Canto ◽  
...  
Keyword(s):  
Food Allergy ◽  
Ex Vivo ◽  
Binding Capacity ◽  
Cross Reactivity ◽  
T Cell Epitopes ◽  
Native Form ◽  
Ige Binding ◽  
Pru P 3

Nowadays, treatment of food allergy only considered the avoidance of the specific food. However, the possibility of cross-reactivity makes this practice not very effective. Immunotherapy may exhibit as a good alternative to food allergy treatment. The use of hypoallergenic molecules with reduced IgE binding capacity but with ability to stimulate the immune system is a promising tool which could be developed for immunotherapy. In this study, three mutants of Pru p 3, the principal allergen of peach, were produced based on the described mimotope and T cell epitopes, by changing the specific residues to alanine, named asPru p 3.01, Pru p 3.02, andPru p 3.03.Pru p 3.01showed very similar allergenic activity as the wild type byin vitroassays. However,Pru p 3.02andPru p 3.03presented reduced IgE binding with respect to the native form, byin vitro,ex vivo,and in vivo assays. In addition,Pru p 3.03had affected the IgG4 binding capacity and presented a random circular dichroism, which was reflected in the nonrecognition by specific antibodies anti-Pru p 3. Nevertheless, bothPru p 3.02andPru p 3.03maintained the binding to IgG1 and their ability to activate T lymphocytes. Thus,Pru p 3.02andPru p 3.03could be good candidates for potential immunotherapy in peach-allergic patients.

scholarly journals Pollen concentrations of some plants in the air over Olszanica (Bieszczady Niskie Mountains) and Wrocław in the 2008 season

2012 ◽  
Vol 63 (2) ◽  
pp. 97-103
Author(s):  
Małgorzata Malkiewicz ◽  
Kamilla Klaczak
Keyword(s):  
Pollen Season ◽  
Birch Pollen ◽  
Urban Site ◽  
Rural Environment ◽  
Pollen Allergens ◽  
Pollen Concentrations ◽  
Allergenic Activity ◽  
Birch Pollen Allergen ◽  
Burkard Trap ◽  
Pollen Seasons

This paper presents the results of an analysis of pollen season patterns for taxa which show the strongest allergenic activity (alder, birch, grasses, and mugwort) in 2008 in the air over Wrocław and Olszanica. The study was carried out using the volumetric method (Burkard trap). The results show variation in pollen seasons between the analyzed localities. An attempt was made to find out in which of the sites in question - the urban site or the rural one - there was a greater risk of allergens of the selected plants. The results of the present study show that the alder, birch and grass pollen seasons in 2008 started and ended earlier in Wrocław, and maximum pollen concentrations were definitely lower. But the mugwort pollen season started earlier and ended much later in Olszanica, while maximum pollen concentration of this taxon was more than twice lower than in Wrocław. In 2008 in the investigated localities, the highest pollen concentrations of the plants in question occurred in the following months: alder in February, birch in April, grasses in June, while mugwort in August. In 2008 alder and birch pollen allergen risk was comparable in the investigated urban and rural environment. However, grass and mugwort pollen allergens posed a significantly greater threat in the rural environment than in Wrocław.

Post-translational phosphorylation affects the IgE binding capacity of caseins

FEBS Letters ◽  
2000 ◽  
Vol 467 (2-3) ◽  
pp. 239-244 ◽  
Author(s):  
H. Bernard ◽  
H. Meisel ◽  
C. Creminon ◽  
J.M. Wal
Keyword(s):  
Binding Capacity ◽  
Ige Binding
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