Diagnosis of Grass Pollen Allergy with Recombinant Timothy Grass (Phleum pratense) Pollen Allergens

1992 ◽  
Vol 97 (4) ◽  
pp. 287-294 ◽  
Author(s):  
R. Valenta ◽  
S. Vrtala ◽  
C. Ebner ◽  
D. Kraft ◽  
O. Scheiner
Keyword(s):  
Grass Pollen ◽  
Pollen Allergy ◽  
Phleum Pratense ◽  
Pollen Allergens ◽  
Grass Pollen Allergy ◽  
Timothy Grass

scholarly journals Sensitization to timothy grass pollen allergenic molecules in children

2013 ◽  
Vol 8 ◽  
Author(s):  
Alessandra Scaparrotta ◽  
Marcello Verini ◽  
Nicola Pietro Consilvio ◽  
Anna Cingolani ◽  
Daniele Rapino ◽  
...  
Keyword(s):  
Grass Pollen ◽  
Pollen Allergy ◽  
Phleum Pratense ◽  
Pollen Extract ◽  
Mediterranean Population ◽  
Grass Pollen Allergy ◽  
Timothy Grass ◽  
Timothy Grass Pollen ◽  
Species Specific

Background: Grass pollens are significant elicitors of IgE-mediated allergic disease in the world and timothy (Phleum pratense) is one of the most important pollens of the family. Molecular and biochemical characterization of Phleum pratense has revealed several allergen components: rPhl p 1 and rPhl p 5 have been shown to be “Species Specific Allergens”, while the profilin rPhl p 12 and the calcium-binding protein rPhl p 7 are the principal Cross-Reactive components. Methods: In this study the pattern of sensitization to rPhl p 1, rPhl p 5, rPhl p 7 and rPhl p 12 was analyzed in children with asthma and/or rhinoconjunctivitis and grass pollen allergy, in order to evaluate the frequency of sensitization to allergenic molecules of Phleum pratense among pediatric subjects allergic to grass pollen in a Mediterranean population. The correlation of sensitization to these Phleum allergenic molecules with IgE against grass pollen extract and its variation according to age and level of IgE against grass pollen extract were evaluated. Results: IgE against to rPhl p 1 were found in 99% (205/207) of patients, to rPhl p 5 in 67% (139/207), to rPhl p 12 in 32% (66/207) and to rPhl p 7 only in 5% (10/207). Sensitization only to “Species Specific” (rPhl p1, rPhl p5) allergenic molecules of Phleum pratense was detected in 65% (135/207) of children. Our data show the predominant role of rPhl p 1 in pediatric populations as the most relevant sensitizing allergen detectable at all ages and at all levels of timothy grass pollen-specific IgE antibodies, while the importance of rPhl p 5 rises with the increase of patients’ age and with grass pollen IgE levels. Conclusions: The assessment of sensitization to grass pollen allergenic molecules could help develop a better characterization of allergic sensitization in grass pollen allergy in children, which may be different in every patient. It could also enable clinicians to give more specific and effective immunotherapy, based on allergenic molecule sensitization.

scholarly journals The importance of cross-reactivity in grass pollen allergy

2014 ◽  
Vol 66 (3) ◽  
pp. 1149-1155 ◽  
Author(s):  
Ivana Aleksic ◽  
Olga Vuckovic ◽  
Katarina Smiljanic ◽  
Marija Gavrovic-Jankulovic ◽  
Vera Krsmanovic ◽  
...  
Keyword(s):  
Grass Pollen ◽  
Pollen Allergy ◽  
Immunoblot Analysis ◽  
Cross Reactivity ◽  
Phleum Pratense ◽  
Pollen Extract ◽  
Grass Pollen Allergy ◽  
Number Of Patients

According to the data obtained from in vivo and in vitro testing in Serbia, a significant number of patients have allergic symptoms caused by grass pollen. We examined the protein composition of grass pollens (Dactylis glomerata, Lolium perenne and Phleum pratense) and cross-reactivity in patients allergic to grass pollen from our region. The grass pollen allergen extract was characterized by SDS-PAGE, while cross-reactivity of single grass pollens was revealed by immunoblot analysis. A high degree of cross-reactivity was demonstrated for all three single pollens in the sera of allergic patients compared to the grass pollen extract mixture. Confirmation of the existence of cross-reactivity between different antigenic sources facilitates the use of monovalent vaccines, which are easier to standardize and at the same time prevent further sensitization of patients and reduces adverse reactions.

Molecular profiles of IgE to Phleum pratense in children with grass pollen allergy: Implications for specific immunotherapy

2012 ◽  
Vol 129 (3) ◽  
pp. 834-839.e8 ◽  
Author(s):  
Salvatore Tripodi ◽  
Tullio Frediani ◽  
Sandra Lucarelli ◽  
Francesco Macrì ◽  
Giuseppe Pingitore ◽  
...  
Keyword(s):  
Grass Pollen ◽  
Specific Immunotherapy ◽  
Pollen Allergy ◽  
Phleum Pratense ◽  
Grass Pollen Allergy ◽  
Molecular Profiles

scholarly journals Grass pollen allergy: a disease-modifying sublingual allergen-specific immunotherapy with the SQ timothy grass extract tablet

2020 ◽  
Vol 17 (1) ◽  
pp. 85-92
Author(s):  
Alla Olegovna Litovkina ◽  
Eugenii Valentinovich Smolnikov ◽  
Olga Gurievna Elisyutina ◽  
Elena Sergeevna Fedenko
Keyword(s):  
Grass Pollen ◽  
Pollen Allergy ◽  
Allergic Diseases ◽  
Economic Problem ◽  
Grass Species ◽  
Grass Pollen Allergy ◽  
Allergen Specific Immunotherapy ◽  
Timothy Grass ◽  
Disease Modifying Therapy ◽  
Disease Modifying

Introduction. Nowadays pollen allergy (hay fever) is one of the most common allergic diseases. Due to the ubiquity of grass species and the long pollination season, grass pollen allergy is an important social and economic problem. Summary. In this review we discuss the clinical data on the use of the SQ timothy grass sublingual immunotherapy (SLIT) tablet for the treatment of allergic diseases caused by grass pollen. The data of various studies demonstrate a significant long-term clinical effect after 1 course of SLIT with this allergen. Conclusions. Based on the studies, the SQ grass SLIT-tablet is established to be a disease-modifying therapy.

Sign in / Sign up

Export Citation Format

Share Document