scholarly journals Cervical and Vulvar Intraepithelial Neoplasia after Treatment with Oral Isotretinoin for Severe Acne Vulgaris

2009 ◽  
Vol 1 (1) ◽  
pp. 49-51
Author(s):  
M.N. Al Hallak ◽  
N. Zouain
Keyword(s):  
Acne Vulgaris ◽  
Intraepithelial Neoplasia ◽  
Vulvar Intraepithelial Neoplasia ◽  
Severe Acne ◽  
Oral Isotretinoin

scholarly journals Standard daily dosage versus pulse dosage of Isotretinoin in acne vulgaris: A hospital based comparative study

2018 ◽  
Vol 7 (2) ◽  
pp. 68-74
Author(s):  
Eliz Aryal ◽  
SB Shrestha ◽  
G Pokhrel ◽  
S Bhattarrai
Keyword(s):  
Side Effects ◽  
Comparative Study ◽  
Acne Vulgaris ◽  
College Teaching ◽  
Poor Response ◽  
Lumbosacral Spine ◽  
Daily Regimen ◽  
Severe Acne ◽  
Pulse Dose ◽  
Oral Isotretinoin

Background: Acne is a multi factorial disease ranging from a couple of comedones and pustules to severe nodulocystic fulminantacne. Isotretinoin (13-cis-retinoic-acid) drug affect all the factors involved in pathogenesis of acne and approved by Food and Drug Administration in 1982. It causes several dose-dependent mucocutaneous and systemic side effects and cost effectObjective: To assess and compare the efficacy and tolerability of two regimens (daily conventional and pulse dose) in moderate to severe acne vulgaris.Methodology: This is a prospective randomized comparative study in moderate to severe acne vulgaris in Kathmandu Medical College Teaching Hospital. The patients were randomly divided into two groups (A and B). In group A conventional dose of 20 mg of oral isotretinoin was given daily and in group B 20 mg of oral isotretinoin was given thrice (Pulse Dosage in alternate day) in a week for six months. The baseline haematological, biochemical and radiological (lumbosacral spine) was compare on first, third and six month.Results: Seventy-four patients were enrolled with mean age of 21.73 years. Patients with daily regimen show good response throughout the therapy for six months (1st, 3rd 6th months), where as those in pulse therapy show moderate to poor response during early month and gradually improve by end of sixth month. At end of sixth month, both the regimen show good response and was statistically significant.Conclusion: However, the pulse dose regimen makes the treatment more acceptable, for patients with acne than the classical standard daily regimen, in term of side effects and cost effectiveness and patient compliance. Journal of Kathmandu Medical CollegeVol. 7, No. 2, Issue 24, Apr.-Jun., 2018, Page: 68-74

scholarly journals A randomized comparative trial of two low-dose oral isotretinoin regimens in moderate to severe acne vulgaris

2016 ◽  
Vol 7 (5) ◽  
pp. 378 ◽  
Author(s):  
DaulatRam Dhaked ◽  
RamSingh Meena ◽  
Anshul Maheshwari ◽  
UmaShankar Agarwal ◽  
Saroj Purohit
Keyword(s):  
Low Dose ◽  
Acne Vulgaris ◽  
Comparative Trial ◽  
Severe Acne ◽  
Dose Oral ◽  
Oral Isotretinoin

scholarly journals Survey of dermatologists on the clinical need for oral isotretinoin in the treatment of acne conglobata and severe acne vulgaris

2021 ◽  
Vol 38 (4) ◽  
pp. 629-634
Author(s):  
Nobukazu Hayashi ◽  
Yu Sasaki ◽  
Ichiro Kurokawa ◽  
Miki Tanioka ◽  
Fukumi Furukawa ◽  
...  
Keyword(s):  
Acne Vulgaris ◽  
Severe Acne ◽  
Acne Conglobata ◽  
Oral Isotretinoin

The effect of continuous high versus low dose oral isotretinoin regimens on dermcidin expression in patients with moderate to severe acne vulgaris

2018 ◽  
Vol 31 (6) ◽  
pp. e12715 ◽  
Author(s):  
Magdy Abd El Aziz Ragab ◽  
Salma Samir Omar ◽  
Andrew Collier ◽  
Reham Abdel Haleem Abo El-Wafa ◽  
Neveen Gomaa
Keyword(s):  
Low Dose ◽  
Acne Vulgaris ◽  
Severe Acne ◽  
Dose Oral ◽  
Oral Isotretinoin

scholarly journals Treatment of moderate to severe acne vulgaris with an oral isotretinoin similar to the reference product

2016 ◽  
Vol 8 (2) ◽  
Author(s):  
Fabíola Rosa Picosse ◽  
Danielle Cristine Bonatto ◽  
Karime Marques Hassun ◽  
Sérgio Talarico Filho ◽  
David Rubem Azulay ◽  
...  
Keyword(s):  
Reference Product ◽  
Acne Vulgaris ◽  
Severe Acne ◽  
Oral Isotretinoin

scholarly journals Comparative Efficacy and Safety of Low Dose versus High Dose Isotretinoin in Severe Acne Vulgaris Patients

2019 ◽  
Vol 8 (1) ◽  
pp. 18-22
Author(s):  
Maria Syed ◽  
Syed Afaq Ahmed
Keyword(s):  
Side Effects ◽  
Low Dose ◽  
Acne Vulgaris ◽  
High Dose ◽  
High Dose Regimen ◽  
Severe Acne ◽  
Dose Oral ◽  
Group A ◽  
Oral Isotretinoin ◽  
Group B

Background: Oral isotretinoin is the recommended treatment for acne vulgaris, a skin disease especially common in teenagers and adolescents. This study was designed to compare the efficacy and safety of low dose with high dose isotretinoin in severe acne vulgaris patients.Material and Methods: This randomized controlled trial included 110 patients with a clinical diagnosis of acne vulgaris. They were divided into two groups. Both groups were matched for age (mean 18.2±3.7 vs 17.6±3.2 years), weight (mean 58±10.2 vs 60.7±9.3 Kg), gender and disease duration (3±1.1 vs 3±1.0 years). Group A received low dose oral isotretinoin (20 mg/day) while group B received standard high dose regimen (1mg/kg/day). All patients were followed up for 16 weeks to assess efficacy (assessment of complete remission) and safety (mucocutaneous side effects). All calculations were performed using SPSS v. 16 with p value <0.05 considered as statistically significant.Results: There was no statistically significant difference in efficacy. However, significantly fewer mucocutaneous side effects were reported in group A (80%) as compared to group B (100%). This safety profile spectrum was observed across all pre-defined subsets i.e chielitis (78.1% vs 98.2%), dry skin (69.1% vs 92.7%), dry mouth (47.2% vs 72.7%) and facial rash (12.7% vs 30.9%).Conclusion: In patients with severe acne vulgaris, efficacy (complete remission) of low dose oral isotretinoin is almost equal to conventional high dose regimen but it is statistically superior in terms of safety (mucocutaneous side effects).

scholarly journals A randomized open label comparative study to determine the various side effects and patient satisfaction of low dose continuous versus low dose intermittent oral isotretinoin therapy in moderate to severe acne vulgaris

2018 ◽  
Vol 7 (6) ◽  
pp. 1169
Author(s):  
Santhosh A. Shetti ◽  
Nagesh H. N. ◽  
Nagabushan Hanumanthaiah
Keyword(s):  
Patient Satisfaction ◽  
Side Effects ◽  
Low Dose ◽  
Acne Vulgaris ◽  
Once Daily ◽  
Severe Acne ◽  
Treatment Regimens ◽  
Group A ◽  
Oral Isotretinoin ◽  
Group B

Background: Acne Vulgaris is chronic inflammatory disease of pilosebaceous units. Oral isotretinoin is recommended for moderate to severe acne vulgaris who are not responding satisfactorily to conventional therapies. Recent reports indicate that acne patients have been benefiting from the low dose treatment protocols. However, long term daily use of this drug results in frequent side effects such mucocutaneous and systemic side effects. Our aim was to assess and compare the various side effects and patient satisfaction of oral isotretinoin in low dose continuous and intermittent treatment of moderate to severe acne vulgaris.Methods: This was a prospective randomized open labeled comparative study carried out at outpatient department in the Department of Dermatology in Mandya Institute of Medical sciences, Mandya. Patients with moderate to severe acne were assigned equally (50 subjects each) to one of the two treatment regimens by using block randomization technique, Group A was given low dose continuous regimen-20 mg oral isotretinoin once daily for 4 months and Group B was given low dose intermittent regimen-20 mg oral isotretinoin once daily for 1 week out of every 4 weeks. The patients were followed up every 4th week during the treatment period. The patients were examined and side effects were noted in each visit. A six month follow-up evaluation was done to analyze patient satisfaction.Results: Muco-cutaneous dryness was most common adverse effect noted in both the groups A and B. Itching (42%), Alopecia (44%), Myalgia (36%) were seen most commonly in group A and Acne flaring (47%) was most common with group B. With regard to patient satisfaction, in group A 42% were satisfied and 20% were very satisfied, in group B 36% were satisfied and 14% were very satisfied.Conclusions: Study suggests that, Muco-cutaneous dryness was most common side effect in both treatment regimens. Side effects were more frequent with low dose continuous than low dose intermittent isotretinoin regimen. Patient satisfaction was better in continuous regimen.

Sign in / Sign up

Export Citation Format

Share Document