Cholesterol and Skeletal Muscle Health

2009 ◽  
pp. 71-79 ◽  
Author(s):  
Steven E. Riechman ◽  
Chang Woock Lee ◽  
Gentle Chikani ◽  
Vincent C.W. Chen ◽  
Teak Veng Lee
Keyword(s):  
Skeletal Muscle ◽  
Muscle Health

scholarly journals Guanidinoacetic acid as a novel food for skeletal muscle health

2020 ◽  
Vol 73 ◽  
pp. 104129
Author(s):  
Sergej M. Ostojic ◽  
Viktoria Premusz ◽  
Dora Nagy ◽  
Pongrac Acs
Keyword(s):  
Skeletal Muscle ◽  
Novel Food ◽  
Guanidinoacetic Acid ◽  
Muscle Health

scholarly journals Eat like an athlete: insights of sports nutrition science to support active aging in healthy older adults

GeroScience ◽  
2021 ◽  
Author(s):  
Sara Y. Oikawa ◽  
Tristin D. Brisbois ◽  
Luc J. C. van Loon ◽  
Ian Rollo
Keyword(s):  
Skeletal Muscle ◽  
Performance Enhancement ◽  
Protein Supplementation ◽  
Muscle Quality ◽  
Active Aging ◽  
Omega 3 ◽  
Healthy Older Adults ◽  
Increased Risk ◽  
Muscle Health ◽  
Nutritional Strategies

AbstractSkeletal muscle mass losses with age are associated with negative health consequences, including an increased risk of developing metabolic disease and the loss of independence. Athletes adopt numerous nutritional strategies to maximize the benefits of exercise training and enhance recovery in pursuit of improving skeletal muscle quality, mass, or function. Importantly, many of the principles applied to enhance skeletal muscle health in athletes may be applicable to support active aging and prevent sarcopenia in the healthy (non-clinical) aging population. Here, we discuss the anabolic properties of protein supplementation in addition to ingredients that may enhance the anabolic effects of protein (e.g. omega 3 s, creatine, inorganic nitrate) in older persons. We conclude that nutritional strategies used in pursuit of performance enhancement in athletes are often applicable to improve skeletal muscle health in the healthy older population when implemented as part of a healthy active lifestyle. Further research is required to elucidate the mechanisms by which these nutrients may induce favourable changes in skeletal muscle and to determine the appropriate dosing and timing of nutrient intakes to support active aging.

scholarly journals The Microvasculature and Skeletal Muscle Health in Aging

2018 ◽  
Vol 46 (3) ◽  
pp. 172-179 ◽  
Author(s):  
Rian Q. Landers-Ramos ◽  
Steven J. Prior
Keyword(s):  
Skeletal Muscle ◽  
Muscle Health

scholarly journals Interactions of Dichlorodiphenyltrichloroethane (DDT) and Dichlorodiphenyldichloroethylene (DDE) With Skeletal Muscle Ryanodine Receptor Type 1

2019 ◽  
Vol 170 (2) ◽  
pp. 509-524
Author(s):  
Kim M Truong ◽  
Gennady Cherednichenko ◽  
Isaac N Pessah
Keyword(s):  
Skeletal Muscle ◽  
Ryanodine Receptor ◽  
Membrane Vesicles ◽  
Receptor Type ◽  
Dependent Manner ◽  
Concentration Dependent Manner ◽  
Voltage Gated Sodium Channels ◽  
Muscle Health ◽  
Living Organisms

Abstract Dichlorodiphenyltrichloroethane (DDT) and its metabolite dichlorodiphenyldichloroethylene (DDE) are ubiquitous in the environment and detected in tissues of living organisms. Although DDT owes its insecticidal activity to impeding closure of voltage-gated sodium channels, it mediates toxicity in mammals by acting as an endocrine disruptor (ED). Numerous studies demonstrate DDT/DDE to be EDs, but studies examining muscle-specific effects mediated by nonhormonal receptors in mammals are lacking. Therefore, we investigated whether o,p′-DDT, p,p′-DDT, o,p′-DDE, and p,p′-DDE (DDx, collectively) alter the function of ryanodine receptor type 1 (RyR1), a protein critical for skeletal muscle excitation-contraction coupling and muscle health. DDx (0.01–10 µM) elicited concentration-dependent increases in [3H]ryanodine ([3H]Ry) binding to RyR1 with o,p′-DDE showing highest potency and efficacy. DDx also showed sex differences in [3H]Ry-binding efficacy toward RyR1, where [3H]Ry-binding in female muscle preparations was greater than male counterparts. Measurements of Ca2+ transport across sarcoplasmic reticulum (SR) membrane vesicles further confirmed DDx can selectively engage with RyR1 to cause Ca2+ efflux from SR stores. DDx also disrupts RyR1-signaling in HEK293T cells stably expressing RyR1 (HEK-RyR1). Pretreatment with DDx (0.1–10 µM) for 100 s, 12 h, or 24 h significantly sensitized Ca2+-efflux triggered by RyR agonist caffeine in a concentration-dependent manner. o,p′-DDE (24 h; 1 µM) significantly increased Ca2+-transient amplitude from electrically stimulated mouse myotubes compared with control and displayed abnormal fatigability. In conclusion, our study demonstrates DDx can directly interact and modulate RyR1 conformation, thereby altering SR Ca2+-dynamics and sensitize RyR1-expressing cells to RyR1 activators, which may ultimately contribute to long-term impairments in muscle health.

scholarly journals Dietary Patterns, Skeletal Muscle Health, and Sarcopenia in Older Adults

Nutrients ◽  
2019 ◽  
Vol 11 (4) ◽  
pp. 745 ◽  
Author(s):  
Antoneta Granic ◽  
Avan Sayer ◽  
Sian Robinson
Keyword(s):  
Older Adults ◽  
Skeletal Muscle ◽  
Dietary Patterns ◽  
Healthy Eating Index ◽  
Muscle Disease ◽  
Nutritional Epidemiology ◽  
Societal Implications ◽  
Increased Risk ◽  
Muscle Health

In recent decades, the significance of diet and dietary patterns (DPs) for skeletal muscle health has been gaining attention in ageing and nutritional research. Sarcopenia, a muscle disease characterised by low muscle strength, mass, and function is associated with an increased risk of functional decline, frailty, hospitalization, and death. The prevalence of sarcopenia increases with age and leads to high personal, social, and economic costs. Finding adequate nutritional measures to maintain muscle health, preserve function, and independence for the growing population of older adults would have important scientific and societal implications. Two main approaches have been employed to study the role of diet/DPs as a modifiable lifestyle factor in sarcopenia. An a priori or hypothesis-driven approach examines the adherence to pre-defined dietary indices such as the Mediterranean diet (MED) and Healthy Eating Index (HEI)—measures of diet quality—in relation to muscle health outcomes. A posteriori or data-driven approaches have used statistical tools—dimension reduction methods or clustering—to study DP-muscle health relationships. Both approaches recognise the importance of the whole diet and potential cumulative, synergistic, and antagonistic effects of foods and nutrients on ageing muscle. In this review, we have aimed to (i) summarise nutritional epidemiology evidence from four recent systematic reviews with updates from new primary studies about the role of DPs in muscle health, sarcopenia, and its components; (ii) hypothesise about the potential mechanisms of ‘myoprotective’ diets, with the MED as an example, and (iii) discuss the challenges facing nutritional epidemiology to produce the higher level evidence needed to understand the relationships between whole diets and healthy muscle ageing.

scholarly journals Erythrocyte Long Chain Omega 3 Fatty Acids Are Associated with Higher Lean Mass in Postmenopausal Women Newly Diagnosed with Breast Cancer (P05-024-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Martha Belury ◽  
Rachel Cole ◽  
Rebecca Andridge ◽  
Qing Xie ◽  
Ashleigh Keiter ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Skeletal Muscle ◽  
Fatty Acids ◽  
Body Composition ◽  
Lean Mass ◽  
Cardiometabolic Health ◽  
Omega 3 ◽  
Appendicular Lean Mass ◽  
Muscle Health ◽  
Long Chain

Abstract Objectives Cancer contributes to adverse changes in body composition that may increase risk of cardiometabolic diseases. Skeletal muscle is a main driver of cardiometabolic health. We hypothesize that higher intake of long chain omega-3 polyunsaturated fatty acids (LCn3PUFAs) is associated with muscle health. This study evaluates whether LCn3PUFA exposure assessed in diet and in blood is associated with markers of muscle health in women with breast cancer. Methods This is a cross-sectional analysis evaluating LCn3PUFA exposure and markers of muscle health in women (N = 150) prior to treatment for breast cancer. Exposure to LCn3PUFAs was assessed by a diet history questionnaire (DHQ), a question specifically about supplement usage and biomarker of LCn3PUFAs in red blood cells (RBC). Body composition were measured at the same visit using dual x-ray absorptiometry. Linear regression models were used to test for associations. Results 13% (N = 19) of women reported using fish oil supplements (e.g., Supplement Users) and had significantly higher levels of RBC LCn3PUFAs than Supplement Non-users. In Supplement Non-users, there was a positive association between reported dietary exposure by DHQ and RBC LCn3PUFA levels. The n3 index (e.g., sum of RBC EPA + DHA) and DHA (22:6n3) were positively associated with appendicular lean mass/BMI. There were no significant correlations between RBC LCn3PUFAs with grip strength and or other measurements of body composition. Conclusions As a biomarker of intake, RBC LCn3PUFAs are positively associated with appendicular lean mass, a measure of skeletal muscle mass. A future study should prospectively evaluate whether higher LCn3PUFA exposure (as measured in blood) is associated with maintaining better muscle health during and following cancer treatment. Funding Sources Funding was provided by the National Cattleman's Beef Association, NIH (JKG) CA186720, Ohio Agriculture Research and Development Center and the Carol S. Kennedy Professorship.

scholarly journals P2X receptor signaling in skeletal muscle health and disease

2013 ◽  
Vol 2 (6) ◽  
pp. 265-274 ◽  
Author(s):  
Christopher N. J. Young ◽  
Anthony Sinadinos ◽  
Dariusz C. Gorecki
Keyword(s):  
Skeletal Muscle ◽  
P2x Receptor ◽  
Receptor Signaling ◽  
Health And Disease ◽  
Muscle Health
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