Mast Cell Differentiation in Cultures of T Cell-Depleted Mesenteric Lymph Node Cells from Nippostrongylus brasiliensis-lnfected Mice

1988 ◽  
Vol 85 (2) ◽  
pp. 137-144 ◽  
Author(s):  
Thomas F. Huff ◽  
David E. Justus
Keyword(s):  
Mast Cell ◽  
Lymph Node ◽  
Cell Differentiation ◽  
T Cell ◽  
Mesenteric Lymph Node ◽  
Mesenteric Lymph ◽  
Lymph Node Cells

Evidence for the involvement of a bone marrow-derived cell population in the immune expulsion ofTrichinella spiralis

Parasitology ◽  
1977 ◽  
Vol 74 (3) ◽  
pp. 225-234 ◽  
Author(s):  
D. Wakelin ◽  
Margaret M. Wilson
Keyword(s):  
Bone Marrow ◽  
Lymph Node ◽  
Cell Population ◽  
Mesenteric Lymph Node ◽  
Trichinella Spiralis ◽  
Mesenteric Lymph ◽  
Lymph Node Cells

When mice were irradiated immediately before infection withTrichinella spiralisthere was a profound and long-lasting interference with their ability to expel adult worms from the intestine. Irradiation given after the fifth day of infection was progressively less effective in this respect. The ability to expel worms was not restored when mesenteric lymph node cells (MLNC) were transferred (a) on the day of infection in mice irradiated one day previously, or (b) on day 7 of an infection in mice irradiated on day 6, even though the MLNC transferred immunity to intact recipients. Transfer of bone marrow (BM) alone was also without effect. However, worm explusion was restored if, following irradiation and injection of BM, 10 days were allowed for BM differentiation before transfer of MLNC. This restoration was effective even after lethal levels of irradiation and was clearly dependent upon a donor-derived BM component cooperating with, or responding to, the activity of the transferred MLNC. The possibility that the BM component is non-lymphoid in nature is discussed.

Dietary effects on insulin and nutrient metabolism in mesenteric lymph node cells, splenocytes, and pancreatic islets of BB rats

Metabolism ◽  
2000 ◽  
Vol 49 (9) ◽  
pp. 1111-1117 ◽  
Author(s):  
Fraser W. Scott ◽  
Elizabeth Olivares ◽  
Abdullah Sener ◽  
Willy J. Malaisse
Keyword(s):  
Lymph Node ◽  
Pancreatic Islets ◽  
Mesenteric Lymph Node ◽  
Nutrient Metabolism ◽  
Dietary Effects ◽  
Mesenteric Lymph ◽  
Bb Rats ◽  
Lymph Node Cells

scholarly journals Adoptive transfer of nontransgenic mesenteric lymph node cells induces colitis in athymic HLA-B27 transgenic nude rats

2006 ◽  
Vol 143 (3) ◽  
pp. 474-483 ◽  
Author(s):  
F. Hoentjen ◽  
S. L. Tonkonogy ◽  
B. Liu ◽  
R. B. Sartor ◽  
J. D. Taurog ◽  
...  
Keyword(s):  
Lymph Node ◽  
Adoptive Transfer ◽  
Mesenteric Lymph Node ◽  
Hla B27 ◽  
Mesenteric Lymph ◽  
Nude Rats ◽  
Lymph Node Cells

Specific cross-immunity between Trichinella spiralis and Trichuris muris: immunization with heterologous infections and antigens and transfer of immunity with heterologous immune mesenteric lymph node cells

Parasitology ◽  
1982 ◽  
Vol 84 (2) ◽  
pp. 381-389 ◽  
Author(s):  
T. D. G. Lee ◽  
R. K. Grencis ◽  
D. Wakelin
Keyword(s):  
Lymph Node ◽  
Mesenteric Lymph Node ◽  
Primary Infection ◽  
Trichinella Spiralis ◽  
The Other ◽  
Trichuris Muris ◽  
Mesenteric Lymph ◽  
Heterologous Challenge ◽  
Lymph Node Cells ◽  
Cross Immunity

SUMMARYInfections with either 300 infective Trichinella spiralis larvae or 400 embryonated eggs of Trichuris muris were effective in eliciting accelerated expulsion of heterologous challenge infections given 20 days after the primary infection. Accelerated expulsion could also be achieved by the administration of soluble crude worm antigen given 12 days prior to heterologous challenge or by adoptive transfer of mesenteric lymph node cells taken from mice infected with the heterologous parasite. Each species is capable of eliciting an accelerated secondary expulsion response in hosts that have been actively or adoptively immunized against the other species and these results are taken to indicate that there is a specific cross-immunity between T. spiralis and T. muris due to shared antigens. It is postulated that these shared antigens are derived from stichocyte granules.

scholarly journals Host Responses to Persistent Mycobacterium avium SubspeciesparatuberculosisInfection in Surgically Isolated Bovine Ileal Segments

2012 ◽  
Vol 20 (2) ◽  
pp. 156-165 ◽  
Author(s):  
Chandrashekhar Charavaryamath ◽  
Patricia Gonzalez-Cano ◽  
Patrick Fries ◽  
Susantha Gomis ◽  
Kimberley Doig ◽  
...  
Keyword(s):  
Lymph Node ◽  
T Cell ◽  
Lamina Propria ◽  
Mycobacterium Avium ◽  
Mesenteric Lymph Node ◽  
Cell Receptor ◽  
Host Responses ◽  
Necrosis Factor Alpha ◽  
Content Type ◽  
Mesenteric Lymph

ABSTRACTA lack of appropriate disease models has limited our understanding of the pathogenesis of persistent enteric infections withMycobacterium aviumsubsp.paratuberculosis. A model was developed for the controlled delivery of a defined dose ofM. aviumsubsp.paratuberculosisto surgically isolated ileal segments in newborn calves. The stable intestinal segments enabled the characterization of host responses to persistentM. aviumsubsp.paratuberculosisinfections after a 9-month period, including an analysis of local mucosal immune responses relative to an adjacent uninfected intestinal compartment.M. aviumsubsp.paratuberculosisremained localized at the initial site of intestinal infection and was not detected by PCR in the mesenteric lymph node.M. aviumsubsp.paratuberculosis-specific T cell proliferative responses included both CD4 and γδ T cell receptor (γδTcR) T cell responses in the draining mesenteric lymph node. The levels of CD8+and γδTcR+T cells increased significantly (P< 0.05) in the lamina propria, andM. aviumsubsp.paratuberculosis-specific tumor necrosis factor alpha (TNF-α) and gamma interferon secretion by lamina propria leukocytes was also significantly (P< 0.05) increased. There was a significant (P< 0.05) accumulation of macrophages and dendritic cells (DCs) in the lamina propria, but the expression of mucosal toll-like receptors 1 through 10 was not significantly changed byM. aviumsubsp.paratuberculosisinfection. In conclusion, surgically isolated ileal segments provided a model system for the establishment of a persistent and localized entericM. aviumsubsp.paratuberculosisinfection in cattle and facilitated the analysis ofM. aviumsubsp.paratuberculosis-specific changes in mucosal leukocyte phenotype and function. The accumulation of DC subpopulations in the lamina propria suggests that further investigation of mucosal DCs may provide insight into host responses toM. aviumsubsp.paratuberculosisinfection and improve vaccine strategies to preventM. aviumsubsp.paratuberculosisinfection.

Defect in TCR-CD3ζ signaling mediates T cell hypo-responsiveness in mesenteric lymph node

2008 ◽  
Vol 45 (14) ◽  
pp. 3748-3755 ◽  
Author(s):  
Hwa-Jung Yi ◽  
Choong-Gu Lee ◽  
Ho-Keun Kwon ◽  
Jae-Seon So ◽  
Anupama Sahoo ◽  
...  
Keyword(s):  
Lymph Node ◽  
T Cell ◽  
Mesenteric Lymph Node ◽  
Mesenteric Lymph
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