Intravenous calcitriol administration modulates mesenteric lymph node CD4 + T‐cell polarization and attenuates intestinal inflammation in obese mice complicated with polymicrobial sepsis

2021 ◽  
Author(s):  
Chiu‐Li Yeh ◽  
Jin‐Ming Wu ◽  
Po‐Jen Yang ◽  
Po‐Chu Lee ◽  
Kuen‐Yuan Chen ◽  
...  
Keyword(s):  
Lymph Node ◽  
T Cell ◽  
Mesenteric Lymph Node ◽  
Intestinal Inflammation ◽  
Cell Polarization ◽  
Polymicrobial Sepsis ◽  
Cd4 T Cell ◽  
Obese Mice ◽  
Mesenteric Lymph ◽  
T Cell Polarization

scholarly journals T-Cell-Receptor-Dependent Signal Intensity Dominantly Controls CD4+ T Cell Polarization In Vivo

Immunity ◽  
2014 ◽  
Vol 41 (1) ◽  
pp. 63-74 ◽  
Author(s):  
Nicholas van Panhuys ◽  
Frederick Klauschen ◽  
Ronald N. Germain
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Signal Intensity ◽  
Cell Receptor ◽  
Cell Polarization ◽  
Cd4 T Cell ◽  
Dependent Signal ◽  
T Cell Polarization

scholarly journals Host Responses to Persistent Mycobacterium avium SubspeciesparatuberculosisInfection in Surgically Isolated Bovine Ileal Segments

2012 ◽  
Vol 20 (2) ◽  
pp. 156-165 ◽  
Author(s):  
Chandrashekhar Charavaryamath ◽  
Patricia Gonzalez-Cano ◽  
Patrick Fries ◽  
Susantha Gomis ◽  
Kimberley Doig ◽  
...  
Keyword(s):  
Lymph Node ◽  
T Cell ◽  
Lamina Propria ◽  
Mycobacterium Avium ◽  
Mesenteric Lymph Node ◽  
Cell Receptor ◽  
Host Responses ◽  
Necrosis Factor Alpha ◽  
Content Type ◽  
Mesenteric Lymph

ABSTRACTA lack of appropriate disease models has limited our understanding of the pathogenesis of persistent enteric infections withMycobacterium aviumsubsp.paratuberculosis. A model was developed for the controlled delivery of a defined dose ofM. aviumsubsp.paratuberculosisto surgically isolated ileal segments in newborn calves. The stable intestinal segments enabled the characterization of host responses to persistentM. aviumsubsp.paratuberculosisinfections after a 9-month period, including an analysis of local mucosal immune responses relative to an adjacent uninfected intestinal compartment.M. aviumsubsp.paratuberculosisremained localized at the initial site of intestinal infection and was not detected by PCR in the mesenteric lymph node.M. aviumsubsp.paratuberculosis-specific T cell proliferative responses included both CD4 and γδ T cell receptor (γδTcR) T cell responses in the draining mesenteric lymph node. The levels of CD8+and γδTcR+T cells increased significantly (P< 0.05) in the lamina propria, andM. aviumsubsp.paratuberculosis-specific tumor necrosis factor alpha (TNF-α) and gamma interferon secretion by lamina propria leukocytes was also significantly (P< 0.05) increased. There was a significant (P< 0.05) accumulation of macrophages and dendritic cells (DCs) in the lamina propria, but the expression of mucosal toll-like receptors 1 through 10 was not significantly changed byM. aviumsubsp.paratuberculosisinfection. In conclusion, surgically isolated ileal segments provided a model system for the establishment of a persistent and localized entericM. aviumsubsp.paratuberculosisinfection in cattle and facilitated the analysis ofM. aviumsubsp.paratuberculosis-specific changes in mucosal leukocyte phenotype and function. The accumulation of DC subpopulations in the lamina propria suggests that further investigation of mucosal DCs may provide insight into host responses toM. aviumsubsp.paratuberculosisinfection and improve vaccine strategies to preventM. aviumsubsp.paratuberculosisinfection.

Defect in TCR-CD3ζ signaling mediates T cell hypo-responsiveness in mesenteric lymph node

2008 ◽  
Vol 45 (14) ◽  
pp. 3748-3755 ◽  
Author(s):  
Hwa-Jung Yi ◽  
Choong-Gu Lee ◽  
Ho-Keun Kwon ◽  
Jae-Seon So ◽  
Anupama Sahoo ◽  
...  
Keyword(s):  
Lymph Node ◽  
T Cell ◽  
Mesenteric Lymph Node ◽  
Mesenteric Lymph

Advanced age negatively influences mesenteric lymph node T cell responses after burn injury

2003 ◽  
Vol 86 (2) ◽  
pp. 177-182 ◽  
Author(s):  
Mashkoor A. Choudhry ◽  
Timothy P. Plackett ◽  
Eric M. Schilling ◽  
Douglas E. Faunce ◽  
Richard L. Gamelli ◽  
...  
Keyword(s):  
Lymph Node ◽  
T Cell ◽  
Mesenteric Lymph Node ◽  
Burn Injury ◽  
T Cell Responses ◽  
Advanced Age ◽  
Cell Responses ◽  
Mesenteric Lymph
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