Anticancer Activity and Differentially Expressed Genes in Head and Neck Cancer Cells Treated with a Novel Cyclin-Dependent Kinase Inhibitor

Chemotherapy ◽  
2009 ◽  
Vol 55 (5) ◽  
pp. 353-362 ◽  
Author(s):  
Ho Cheol Shin ◽  
Dal Won Song ◽  
Won Ki Baek ◽  
Seong Ryong Lee ◽  
Taeg Kyu Kwon ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Anticancer Activity ◽  
Cancer Cells ◽  
Differentially Expressed Genes ◽  
Neck Cancer ◽  
Kinase Inhibitor ◽  
Differentially Expressed ◽  
Cyclin Dependent Kinase ◽  
Cyclin Dependent Kinase Inhibitor

IGF-1R-Mediated Resistance to EGFR Kinase Inhibitor PD158780 in Head and Neck Cancer Cells

2005 ◽  
Vol 133 (2) ◽  
pp. P95-P95
Author(s):  
M JAMESON ◽  
A BECKLER ◽  
L SANDSTROM ◽  
C THOMAS ◽  
P LEVINE
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Cancer Cells ◽  
Neck Cancer ◽  
Kinase Inhibitor ◽  
Egfr Kinase

scholarly journals Low-intensity ultrasound enhances the anticancer activity of cetuximab in human head and neck cancer cells

2012 ◽  
Vol 5 (1) ◽  
pp. 11-16 ◽  
Author(s):  
TAKASHI MASUI ◽  
ICHIRO OTA ◽  
MASATOSHI KANNO ◽  
KATSUNARI YANE ◽  
HIROSHI HOSOI
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Anticancer Activity ◽  
Cancer Cells ◽  
Neck Cancer ◽  
Human Head ◽  
Low Intensity ◽  
Low Intensity Ultrasound

Differentially expressed genes associated withCIS-diamminedichloroplatinum (II) resistance in head and neck cancer using differential display andCDNA microarray

Head & Neck ◽  
2003 ◽  
Vol 25 (3) ◽  
pp. 187-193 ◽  
Author(s):  
Eisaku Higuchi ◽  
Nobuhiko Oridate ◽  
Yasushi Furuta ◽  
Seigo Suzuki ◽  
Hiromitsu Hatakeyama ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Differentially Expressed Genes ◽  
Neck Cancer ◽  
Differential Display ◽  
Differentially Expressed

Differentially Expressed Genes in Head and Neck Cancer

1998 ◽  
Vol 108 (5) ◽  
pp. 639-644 ◽  
Author(s):  
Stefan Gottschlich ◽  
Benedikt J. Folz ◽  
Burkard M. Lippert ◽  
Anna M. Niemann ◽  
Tibor Goeroegh ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Differentially Expressed Genes ◽  
Neck Cancer ◽  
Differentially Expressed

scholarly journals Inhibition of F-Box Protein p45SKP2 Expression and Stabilization of Cyclin-Dependent Kinase Inhibitor p27KIP1 in Vitamin D Analog-Treated Cancer Cells

Endocrinology ◽  
2003 ◽  
Vol 144 (3) ◽  
pp. 749-753 ◽  
Author(s):  
Roberto Lin ◽  
Tian Tian Wang ◽  
Wilson H. Miller ◽  
John H. White
Keyword(s):  
Head And Neck ◽  
Cancer Cells ◽  
Gene Transcription ◽  
Kinase Inhibitor ◽  
Cyclin Dependent Kinase ◽  
P27kip1 Protein ◽  
Protein Levels ◽  
Cyclin Dependent Kinase Inhibitor ◽  
Squamous Carcinoma Cells ◽  
F Box Protein

Treatment of cancer cells with 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] or its analogs induces growth arrest and expression of the cyclin-dependent kinase inhibitor p27KIP1. Although 1,25(OH)2D3 transiently enhances p27kip1 gene transcription in some cells, its effects on p27KIP1 protein levels are generally more gradual and sustained. This suggests that 1,25(OH)2D3 treatment may be stabilizing p27KIP1 protein, which is sensitive to modification by the SCFSKP2 protein ubiquitin ligase and proteosomal degradation. Here, we show that treatment of AT-84 head and neck squamous carcinoma cells with the 1,25(OH)2D3 analog EB1089 increases p27KIP1 protein levels without significantly affecting expression of its mRNA. EB1089 treatment repressed expression of mRNAs encoding the F-box protein p45SKP2, a marker of poor head and neck cancer prognosis, and the cyclin kinase subunit CKS1, which is essential for targeting p45SKP2 to p27KIP1. This coincided with a reduction of total p45SKP2 protein, and p45SKP2 associated with p27KIP1. Consistent with these findings, turnover of p27KIP1 protein was strongly inhibited in the presence of EB1089. A similar reduction in p45SKP2 expression and stabilization of p27KIP1 protein was observed in 1,25(OH)2D3-sensitive UF-1 promyelocytic leukemia cells, which also respond by transiently increasing p27kip1 gene transcription. Our results reveal that 1,25(OH)2D3 analogs increase levels of p27KIP1 in different cell types by inhibiting expression of SCFSKP2 subunits and reducing turnover of p27KIP1 protein.

Selection and validation of differentially expressed genes in head and neck cancer

2004 ◽  
Vol 61 (11) ◽  
pp. 1372-1383 ◽  
Author(s):  
M. A. Kuriakose ◽  
W. T. Chen ◽  
Z. M. He ◽  
A. G. Sikora ◽  
P. Zhang ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Differentially Expressed Genes ◽  
Neck Cancer ◽  
Differentially Expressed

scholarly journals Ionizing radiation affects the composition of the proteome of extracellular vesicles released by head-and-neck cancer cells in vitro

2019 ◽  
Vol 60 (3) ◽  
pp. 289-297 ◽  
Author(s):  
Agata Abramowicz ◽  
Anna Wojakowska ◽  
Lukasz Marczak ◽  
Malgorzata Lysek-Gladysinska ◽  
Mateusz Smolarz ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Ionizing Radiation ◽  
Head And Neck ◽  
Cancer Cells ◽  
Extracellular Vesicles ◽  
Neck Cancer
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