Differentially expressed genes associated withCIS-diamminedichloroplatinum (II) resistance in head and neck cancer using differential display andCDNA microarray

Head & Neck ◽  
2003 ◽  
Vol 25 (3) ◽  
pp. 187-193 ◽  
Author(s):  
Eisaku Higuchi ◽  
Nobuhiko Oridate ◽  
Yasushi Furuta ◽  
Seigo Suzuki ◽  
Hiromitsu Hatakeyama ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Differentially Expressed Genes ◽  
Neck Cancer ◽  
Differential Display ◽  
Differentially Expressed

Differentially Expressed Genes in Head and Neck Cancer

1998 ◽  
Vol 108 (5) ◽  
pp. 639-644 ◽  
Author(s):  
Stefan Gottschlich ◽  
Benedikt J. Folz ◽  
Burkard M. Lippert ◽  
Anna M. Niemann ◽  
Tibor Goeroegh ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Differentially Expressed Genes ◽  
Neck Cancer ◽  
Differentially Expressed

Selection and validation of differentially expressed genes in head and neck cancer

2004 ◽  
Vol 61 (11) ◽  
pp. 1372-1383 ◽  
Author(s):  
M. A. Kuriakose ◽  
W. T. Chen ◽  
Z. M. He ◽  
A. G. Sikora ◽  
P. Zhang ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Differentially Expressed Genes ◽  
Neck Cancer ◽  
Differentially Expressed

Differentially expressed serum haptoglobin alpha chain isoforms with potential application for diagnosis of head and neck cancer

2008 ◽  
Vol 398 (1-2) ◽  
pp. 48-52 ◽  
Author(s):  
Chao-Bin Chen ◽  
Yu-Chieh Su ◽  
Tze-Ta Huang ◽  
Hsu-Chueh Ho ◽  
Ya-Ting Chang ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Potential Application ◽  
Differentially Expressed ◽  
Alpha Chain ◽  
Serum Haptoglobin

scholarly journals Stoichioproteomics study of differentially expressed proteins and pathways in head and neck cancer

2023 ◽  
Vol 83 ◽  
Author(s):  
Y. Lan ◽  
Y. Liang ◽  
X. Xiao ◽  
Y. Shi ◽  
M. Zhu ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Targeted Therapy ◽  
Head And Neck ◽  
Oxygen Content ◽  
Neck Cancer ◽  
Differentially Expressed ◽  
Differentially Expressed Proteins ◽  
Normal Oral Mucosa ◽  
Human Protein Atlas ◽  
Regulation Of Actin Cytoskeleton

Abstract Hypoxia is a prominent feature of head and neck cancer. However, the oxygen element characteristics of proteins and how they adapt to hypoxia microenvironments of head and neck cancer are still unknown. Human genome sequences and proteins expressed data of head and neck cancer were retrieved from pathology atlas of Human Protein Atlas project. Then compared the oxygen and carbon element contents between proteomes of head and neck cancer and normal oral mucosa-squamous epithelial cells, genome locations, pathways, and functional dissection associated with head and neck cancer were also studied. A total of 902 differentially expressed proteins were observed where the average oxygen content is higher than that of the lowly expressed proteins in head and neck cancer proteins. Further, the average oxygen content of the up regulated proteins was 2.54% higher than other. None of their coding genes were distributed on the Y chromosome. The up regulated proteins were enriched in endocytosis, apoptosis and regulation of actin cytoskeleton. The increased oxygen contents of the highly expressed and the up regulated proteins might be caused by frequent activity of cytoskeleton and adapted to the rapid growth and fast division of the head and neck cancer cells. The oxygen usage bias and key proteins may help us to understand the mechanisms behind head and neck cancer in targeted therapy, which lays a foundation for the application of stoichioproteomics in targeted therapy and provides promise for potential treatments for head and neck cancer.

scholarly journals MiR-3168, miR-6125, and miR-4718 as potential predictors of cisplatin-induced nephrotoxicity in patients with head and neck cancer

BMC Cancer ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Julia C. F. Quintanilha ◽  
Maria A. Cursino ◽  
Jessica B. Borges ◽  
Nadine G. Torso ◽  
Larissa B. Bastos ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Area Under The Curve ◽  
Differentially Expressed ◽  
Receiver Operating Characteristic Curves ◽  
Increased Risk ◽  
Differentially Expressed Mirnas ◽  
Mirna Sequencing ◽  
Patients At Risk

Abstract Background No biomarker is available for identifying cancer patients at risk of developing nephrotoxicity when treated with cisplatin. Methods We performed microRNA (miRNA) sequencing using plasma collected 5 days after cisplatin treatment (D5) from twelve patients with head and neck cancer with and without nephrotoxicity (grade ≥ 2 increased serum creatinine). The most differentially expressed miRNAs between the two groups were selected for quantification at baseline and D5 in a larger cohort of patients. The association between miRNAs and nephrotoxicity was evaluated by calculating the odds ratio (OR) from univariate logistic regression. Receiver operating characteristic curves (ROC) were used to estimate the area under the curve (AUC), sensitivity, and specificity. Results MiR-3168 (p = 1.98 × 10− 8), miR-4718 (p = 4.24 × 10− 5), and miR-6125 (p = 6.60 × 10− 5) were the most differentially expressed miRNAs and were further quantified in 43, 48, and 53 patients, respectively. The baseline expression of miR-3168 (p = 0.0456, OR = 1.03, 95% CI: 1.00–1.06) and miR-4718 (p = 0.0388, OR = 1.56, 95% CI: 1.03–2.46) were associated with an increased risk of nephrotoxicity, whereas miR-6125 showed a trend (p = 0.0618, OR = 1.73, 95% CI: 0.98–3.29). MiR-4718 showed the highest AUC (0.77, 95% CI: 0.61–0.93) with sensitivity of 66.76 and specificity of 79.49. Conclusions We have provided evidence of baseline plasmatic expression of miR-3168, miR-6125, and miR-4718 as potential predictors of cisplatin-induced nephrotoxicity.

scholarly journals Human Endogenous Retrovirus Expression Is Associated with Head and Neck Cancer and Differential Survival

Viruses ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 956 ◽  
Author(s):  
Allison R. Kolbe ◽  
Matthew L. Bendall ◽  
Alexander T. Pearson ◽  
Doru Paul ◽  
Douglas F. Nixon ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Normal Tissue ◽  
Endogenous Retroviruses ◽  
The Cancer Genome Atlas ◽  
Differentially Expressed ◽  
Human Endogenous Retrovirus ◽  
Adjacent Normal Tissue ◽  
Herv Expression

Human endogenous retroviruses (HERVs) have been implicated in a variety of human diseases including cancers. However, technical challenges in analyzing HERV sequence data have limited locus-specific characterization of HERV expression. Here, we use the software Telescope (developed to identify expressed transposable elements from metatranscriptomic data) on 43 paired tumor and adjacent normal tissue samples from The Cancer Genome Atlas Program to produce the first locus-specific retrotranscriptome of head and neck cancer. Telescope identified over 3000 expressed HERVs in tumor and adjacent normal tissue, and 1078 HERVs were differentially expressed between the two tissue types. The majority of differentially expressed HERVs were expressed at a higher level in tumor tissue. Differentially expressed HERVs were enriched in members of the HERVH family. Hierarchical clustering based on HERV expression in tumor-adjacent normal tissue resulted in two distinct clusters with significantly different survival probability. Together, these results highlight the importance of future work on the role of HERVs across a range of cancers.

scholarly journals MiR-3168, miR-6125, and miR-4718 as Potential Predictors of Cisplatin-Induced Nephrotoxicity in Patients with Head and Neck Cancer

2021 ◽  
Author(s):  
Julia Quintanilha ◽  
Maria Cursino ◽  
Jessica Borges ◽  
Nadine Torso ◽  
Larissa Bastos ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Area Under The Curve ◽  
Differentially Expressed ◽  
Receiver Operating Characteristic Curves ◽  
Increased Risk ◽  
Differentially Expressed Mirnas ◽  
Mirna Sequencing ◽  
Patients At Risk

Abstract No biomarker is available for identifying cancer patients at risk of developing nephrotoxicity when treated with cisplatin. We performed microRNA (miRNA) sequencing using plasma collected five days after cisplatin treatment (D5) from twelve patients with head and neck cancer with and without nephrotoxicity (grade ≥2 increased serum creatinine). The most differentially expressed miRNAs between the two groups were selected for quantification at baseline and D5 in a larger cohort of patients. The association between miRNAs and nephrotoxicity was evaluated by calculating the odds ratio (OR) from univariate logistic regression. Receiver operating characteristic curves (ROC) were used to estimate the area under the curve (AUC), sensitivity, and specificity. MiR-3168 (p=1.98×10−8), miR-4718 (p=4.24×10−5), and miR-6125 (p=6.60×10−5) were the most differentially expressed miRNAs and were further quantified in 43, 48, and 53 patients, respectively. The baseline expression of miR-3168 (p=0.0456, OR=1.03, 95% CI: 1.00–1.06) and miR-4718 (p=0.0388, OR=1.56, 95% CI: 1.03–2.46) were associated with an increased risk of nephrotoxicity, whereas miR-6125 showed a trend (p=0.0618, OR=1.73, 95% CI: 0.98–3.29). MiR-4718 showed the highest AUC (0.77, 95% CI: 1.74–5.8) with sensitivity of 66.76 and specificity of 79.49. We therefore report baseline plasma miRNAs as potential predictors of cisplatin-induced nephrotoxicity.

scholarly journals MiR-3168, miR-6125, and miR-4718 as potential predictors of cisplatin-induced nephrotoxicity in patients with head and neck cancer

2021 ◽  
Author(s):  
Julia C.F. Quintanilha ◽  
Maria A. Cursino ◽  
Jessica B. Borges ◽  
Nadine G. Torso ◽  
Larissa B. Bastos ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Area Under The Curve ◽  
Differentially Expressed ◽  
Receiver Operating Characteristic Curves ◽  
Increased Risk ◽  
Differentially Expressed Mirnas ◽  
Mirna Sequencing ◽  
Patients At Risk

Abstract Background: No biomarker is available for identifying cancer patients at risk of developing nephrotoxicity when treated with cisplatin. Methods: We performed microRNA (miRNA) sequencing using plasma collected five days after cisplatin treatment (D5) from twelve patients with head and neck cancer with and without nephrotoxicity (grade ≥2 increased serum creatinine). The most differentially expressed miRNAs between the two groups were selected for quantification at baseline and D5 in a larger cohort of patients. The association between miRNAs and nephrotoxicity was evaluated by calculating the odds ratio (OR) from univariate logistic regression. Receiver operating characteristic curves (ROC) were used to estimate the area under the curve (AUC), sensitivity, and specificity. Results: MiR-3168 (p=1.98×10−8), miR-4718 (p=4.24×10−5), and miR-6125 (p=6.60×10−5) were the most differentially expressed miRNAs and were further quantified in 43, 48, and 53 patients, respectively. The baseline expression of miR-3168 (p=0.0456, OR=1.03, 95% CI: 1.00–1.06) and miR-4718 (p=0.0388, OR=1.56, 95% CI: 1.03–2.46) were associated with an increased risk of nephrotoxicity, whereas miR-6125 showed a trend (p=0.0618, OR=1.73, 95% CI: 0.98–3.29). MiR-4718 showed the highest AUC (0.77, 95% CI: 1.74–5.8) with sensitivity of 66.76 and specificity of 79.49. Conclusions: We have provided evidence of baseline plasmatic expression of miR-3168, miR-6125, and miR-4718 as potential predictors of cisplatin-induced nephrotoxicity.

Sign in / Sign up

Export Citation Format

Share Document