Prediction of Lymph Node Metastasis and Prognosis from the Assay of the Expression of Proliferating Cell Nuclear Antigen and DNA Ploidy in Gastric Cancer

Oncology ◽  
1994 ◽  
Vol 51 (3) ◽  
pp. 251-257 ◽  
Author(s):  
Yutaka Yonemura ◽  
Luis Fonseca ◽  
Kouichirou Tsugawa ◽  
Itasu Ninomiya ◽  
Hisashi Matsumoto ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Proliferating Cell Nuclear Antigen ◽  
Dna Ploidy ◽  
Nuclear Antigen ◽  
Node Metastasis ◽  
Proliferating Cell

Prognostic Value of DNA Ploidy and Proliferating Cell Nuclear Antigen in Gastric Cancer

Oncology ◽  
1998 ◽  
Vol 55 (4) ◽  
pp. 300-306 ◽  
Author(s):  
Kazuo Hirose ◽  
Atsushi Iida ◽  
Akio Yamaguchi ◽  
Hidetoshi Onchi ◽  
Hirofumi Awata ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Proliferating Cell Nuclear Antigen ◽  
Prognostic Value ◽  
Dna Ploidy ◽  
Nuclear Antigen ◽  
Proliferating Cell

Dna ploidy is closely linked to tumor invasion, lymph node metastasis, and prognosis in clinical gastric cancer

Cancer ◽  
1988 ◽  
Vol 62 (2) ◽  
pp. 309-313 ◽  
Author(s):  
Daisuke Korenaga ◽  
Takeshi Okamura ◽  
Atsushi Saito ◽  
Hideo Baba ◽  
Keizo Sugimachi
Keyword(s):  
Gastric Cancer ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Tumor Invasion ◽  
Dna Ploidy ◽  
Node Metastasis

scholarly journals Lymph node metastasis-derived gastric cancer cells educate bone marrow-derived mesenchymal stem cells via YAP signaling activation by exosomal Wnt5a

Oncogene ◽  
2021 ◽  
Vol 40 (12) ◽  
pp. 2296-2308
Author(s):  
Mei Wang ◽  
Xinxin Zhao ◽  
Rong Qiu ◽  
Zheng Gong ◽  
Feng Huang ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Metastatic Gastric Cancer ◽  
Gastric Cancer Cells ◽  
Node Metastasis ◽  
Signaling Activation

AbstractLymph node metastasis (LNM), a common metastatic gastric-cancer (GC) route, is closely related to poor prognosis in GC patients. Bone marrow-derived mesenchymal stem cells (BM-MSCs) preferentially engraft at metastatic lesions. Whether BM-MSCs are specifically reprogrammed by LNM-derived GC cells (LNM-GCs) and incorporated into metastatic LN microenvironment to prompt GC malignant progression remains unknown. Herein, we found that LNM-GCs specifically educated BM-MSCs via secretory exosomes. Exosomal Wnt5a was identified as key protein mediating LNM-GCs education of BM-MSCs, which was verified by analysis of serum exosomes collected from GC patients with LNM. Wnt5a-enriched exosomes induced YAP dephosphorylation in BM-MSCs, whereas Wnt5a-deficient exosomes exerted the opposite effect. Inhibition of YAP signaling by verteporfin blocked LNM-GC exosome- and serum exosome-mediated reprogramming in BM-MSCs. Analysis of MSC-like cells obtained from metastatic LN tissues of GC patients (GLN-MSCs) confirmed that BM-MSCs incorporated into metastatic LN microenvironment, and that YAP activation participated in maintaining their tumor-promoting phenotype and function. Collectively, our results show that LNM-GCs specifically educated BM-MSCs via exosomal Wnt5a-elicited activation of YAP signaling. This study provides new insights into the mechanisms of LNM in GC and BM-MSC reprogramming, and will provide potential therapeutic targets and detection indicators for GC patients with LNM.

Predictive factors for lymph node metastasis in additional gastrectomy after endoscopic resection of cT1aN0 gastric cancer

Surgery Today ◽  
2015 ◽  
Vol 46 (9) ◽  
pp. 1031-1038 ◽  
Author(s):  
Satoru Ishii ◽  
Keishi Yamashita ◽  
Hiroshi Kato ◽  
Nobuyuki Nishizawa ◽  
Hideki Ushiku ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Endoscopic Resection ◽  
Predictive Factors ◽  
Node Metastasis ◽  
Additional Gastrectomy
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