Removing Oxygen-Derived Free Radicals Delays Hepatic Metastases and Prolongs Survival in Colonic Cancer

Oncology ◽  
1992 ◽  
Vol 49 (1) ◽  
pp. 58-62 ◽  
Author(s):  
Aws.S. Salim
Keyword(s):  
Free Radicals ◽  
Colonic Cancer ◽  
Hepatic Metastases ◽  
Oxygen Derived Free Radicals

In vivo measurement of oxygen-derived free radicals during reperfusion injury

Microsurgery ◽  
2002 ◽  
Vol 22 (3) ◽  
pp. 108-113 ◽  
Author(s):  
Rolf Büttemeyer ◽  
Andreas W. Philipp ◽  
Julian W. Mall ◽  
Bixia Ge ◽  
Frieder W. Scheller ◽  
...  
Keyword(s):  
Free Radicals ◽  
Reperfusion Injury ◽  
In Vivo Measurement ◽  
Oxygen Derived Free Radicals

Defective Ag-In-S/ZnS Quantum Dots: An Oxygen-derived Free Radicals Scavenger for Mitigating the Macrophage Inflammation

2021 ◽  
Author(s):  
Na Gao ◽  
Jing Jing ◽  
Hengzhi Zhao ◽  
Yazhou Liu ◽  
Chunlei Yang ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Quantum Dots ◽  
Heart Disease ◽  
Free Radicals ◽  
Inflammatory Diseases ◽  
Antioxidant Therapy ◽  
Oxygen Derived Free Radicals ◽  
Promising Strategy

Oxidative stress plays an important role in the development of inflammatory diseases including allergy, heart disease, diabetes and cancer. Nanomaterials-mediated antioxidant therapy is regarded as a promising strategy to treat...

Magnetic starch microspheres in the MR imaging of hepatic metastases

1998 ◽  
Vol 39 (2) ◽  
pp. 161-166
Author(s):  
A. Sundin ◽  
C. Wang ◽  
A. Ericsson ◽  
A.-K. Fahlvik
Keyword(s):  
Mr Imaging ◽  
Detection Rate ◽  
Colonic Cancer ◽  
Spin Echo ◽  
Hepatic Metastases ◽  
Hepatic Veins ◽  
Optimum Detection ◽  
High Doses ◽  
Dose Levels ◽  
Experimental Liver

Purpose: to evaluate reticular endothelial system-specific magnetic starch microspheres (MSM) as an i.v. contrast agent for MR imaging in a model of experimental liver metastases Material and Methods: the study comprised 15 nude rats, 7 of which were carrying hepatic metastases from a human colonic cancer. the 15 rats were examined at 0.5 T using a T1-weighted spin-echo (SE) sequence and a gradientecho sequence. the examinations were performed before and 15 min after the administration of accumulated doses of MSM at 0.25–2.5 mg Fe/kg b.w. the images were compared with corresponding serial liver specimens Results: A loss of liver signal intensity was obtained at all MSM dose levels. No metastases were detected in the pre-contrast images. the optimum detection rate of hepatic metastases was reached with the SE sequence at a dose of 1.0 mg Fe/kg b.w. MSM and the diameters of the smallest lesions depicted were 1 mm. However, in the SE sequence, the measured lesion-to-liver contrast and liver signal damping were highest at the largest dose, indicating a possible image degrading effect of MSM at high doses. Administration of MSM as a short bolus over 30 s resulted in congestion of the liver with dilatation of the hepatic veins. When MSM was instead injected slowly over 5 min, this adverse effect was not seen Conclusion: the use of MSM dramatically increased the detection of experimental hepatic metastases

Oxygen-Derived Free Radicals Mediate Isoflurane-Induced Vasoconstriction of Rabbit Coronary Resistance Arteries

1995 ◽  
Vol 80 (6) ◽  
pp. 1163-1167
Author(s):  
Kyung W. Park ◽  
Hai B. Dai ◽  
Edward Lowenstein ◽  
Amir Darvish ◽  
Frank W. Sellke
Keyword(s):  
Free Radicals ◽  
Coronary Resistance ◽  
Resistance Arteries ◽  
Oxygen Derived Free Radicals
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