The Relationship of the Proliferating Cell Nuclear Antigen Protein to cis-Diamminedichloroplatinum(II) Resistance of a Murine Leukemia Cell Line P388/CDDP

Oncology ◽  
1991 ◽  
Vol 48 (3) ◽  
pp. 234-238 ◽  
Author(s):  
Hitoshi Haneda ◽  
Motoo Katabami ◽  
Hiroshi Miyamoto ◽  
Hiroshi Isobe ◽  
Tooru Shimizu ◽  
...  
Keyword(s):  
Proliferating Cell Nuclear Antigen ◽  
Leukemia Cell ◽  
Leukemia Cell Line ◽  
Nuclear Antigen ◽  
Antigen Protein ◽  
Murine Leukemia Cell ◽  
Relationship Of ◽  
The Relationship ◽  
Proliferating Cell ◽  
Murine Leukemia

Relationship of proliferating cell nuclear antigen (PCNA) in prostatic carcinomas to various clinical parameters

The Prostate ◽  
1992 ◽  
Vol 20 (3) ◽  
pp. 243-253 ◽  
Author(s):  
M. E. Harper ◽  
E. Glynne-Jones ◽  
L. Goddard ◽  
D. W. Wilson ◽  
K. Griffiths ◽  
...  
Keyword(s):  
Proliferating Cell Nuclear Antigen ◽  
Nuclear Antigen ◽  
Clinical Parameters ◽  
Relationship Of ◽  
Proliferating Cell

scholarly journals Induction of erythroid differentiation by inhibition of Ras/ERK pathway in a Friend murine leukemia cell line

Oncogene ◽  
2000 ◽  
Vol 19 (12) ◽  
pp. 1500-1508 ◽  
Author(s):  
Tomoko Matsuzaki ◽  
Ken-ichi Aisaki ◽  
Yasuko Yamamura ◽  
Makoto Noda ◽  
Yoji Ikawa
Keyword(s):  
Cell Line ◽  
Leukemia Cell ◽  
Erythroid Differentiation ◽  
Leukemia Cell Line ◽  
Erk Pathway ◽  
Murine Leukemia Cell ◽  
Murine Leukemia

scholarly journals Emodin Induces Apoptotic Death in Murine Myelomonocytic Leukemia WEHI-3 CellsIn Vitroand Enhances Phagocytosis in Leukemia MiceIn Vivo

2011 ◽  
Vol 2011 ◽  
pp. 1-13 ◽  
Author(s):  
Yuan-Chang Chang ◽  
Tung-Yuan Lai ◽  
Chun-Shu Yu ◽  
Hung-Yi Chen ◽  
Jai-Sing Yang ◽  
...  
Keyword(s):  
Chromatin Condensation ◽  
Leukemia Cell ◽  
Cell Types ◽  
Leukemia Cell Line ◽  
Apoptotic Death ◽  
Murine Leukemia Cell ◽  
Available Information ◽  
Murine Leukemia

Emodin is one of major compounds in rhubarb (Rheum palmatumL.), a plant used as herbal medicine in Chinese population. Although many reports have shown that emodin exhibits anticancer activity in many tumor cell types, there is no available information addressing emodin-affected apoptotic responses in the murine leukemia cell line (WEHI-3) and modulation of the immune response in leukemia mice. We investigated that emodin induced cytotoxic effectsin vitroand affected WEHI-3 cellsin vivo. This study showed that emodin decreased viability and induced DNA fragmentation in WEHI-3 cells. Cells after exposure to emodin for 24 h have shown chromatin condensation and DNA damage. Emodin stimulated the productions of ROS and Ca2+and reduced the level ofΔΨmby flow cytometry. Our results from Western blotting suggest that emodin triggered apoptosis of WEHI-3 cells through the endoplasmic reticulum (ER) stress, caspase cascade-dependent and -independent mitochondrial pathways. Inin vivostudy, emodin enhanced the levels of B cells and monocytes, and it also reduced the weights of liver and spleen compared with leukemia mice. Emodin promoted phagocytic activity bymonocytesandmacrophagesin comparison to the leukemia mice group. In conclusions, emodin induced apoptotic death in murine leukemia WEHI-3 cells and enhanced phagocytosis in the leukemia animal model.

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