Amino Acid Therapy for Patients with Chronic Renal Failure

1987 ◽  
Vol 14 (5) ◽  
pp. 8-11
Author(s):  
J. Bergström ◽  
M. Ahlberg ◽  
A. Alvestrand ◽  
P. Fürst
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Amino Acid ◽  
Acid Therapy

Variations in the Lipid Profile of Patients with Chronic Renal Failure, Treated with Folic Acid

2003 ◽  
Vol 73 (3) ◽  
pp. 215-220 ◽  
Author(s):  
de Gómez Dumm ◽  
Giammona ◽  
Touceda
Keyword(s):  
Renal Failure ◽  
Folic Acid ◽  
Chronic Renal Failure ◽  
Density Lipoprotein ◽  
Plasma Homocysteine ◽  
Lipid Profiles ◽  
Erythrocyte Membranes ◽  
Favorable Effect ◽  
High Dose ◽  
Acid Therapy

Dyslipidemia and increases in plasma homocysteine usually occur at end-stage renal disease; both are recognized as risk factors for atherosclerosis. Folate administration reduces homocysteine concentration. In this study we determined the effect of a high dose of folic acid (40 mg intravenous injection three times a week) on plasma and red blood cell lipid profiles in twelve chronic renal failure patients on regular hemodialysis. Fasting blood samples were taken at the beginning of the study (baseline) and after 21, 42, and 64 days of treatment. Folic acid supplementation decreased plasma homocysteine. Plasma triglyceride levels decreased whereas polyunsaturated fatty acid values increased after 21 days; then they returned to baseline levels at the end of treatment. Total cholesterol and low-density lipoprotein (LDL) cholesterol were higher than those of the baseline during all the study, whereas high-density lipoprotein (HDL) cholesterol was reduced. In erythrocyte membranes, folic acid therapy enhanced cholesterol/phospholipid ratios and the fluorescence anisotropy of diphenyl-hexatriene. We conclude that large doses of folic acid produce a favorable effect, reducing plasma homocysteine levels and protecting patients from atherosclerosis. However, as this therapy induces significant alterations in both plasma and erythrocyte membrane lipid profiles, plasma lipid values should be controlled throughout the treatment of patients with renal failure.

scholarly journals Branched-chain amino acid in chronic renal failure patients: Respiratory and sleep effects

1991 ◽  
Vol 40 (3) ◽  
pp. 539-543 ◽  
Author(s):  
Eldar Söreide ◽  
Björn Skeie ◽  
Olli Kirvelä ◽  
Robert Lynn ◽  
Nancy Ginsberg ◽  
...  
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Amino Acid ◽  
Branched Chain Amino Acid ◽  
Branched Chain

Correction of acidosis in humans with CRF decreases protein degradation and amino acid oxidation

1993 ◽  
Vol 265 (2) ◽  
pp. E230-E235 ◽  
Author(s):  
D. Reaich ◽  
S. M. Channon ◽  
C. M. Scrimgeour ◽  
S. E. Daley ◽  
R. Wilkinson ◽  
...  
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Amino Acid ◽  
Sodium Chloride ◽  
Sodium Bicarbonate ◽  
Acid Oxidation ◽  
Body Protein ◽  
Amino Acid Oxidation ◽  
Kinetics Of ◽  
Amino Acid Concentrations

The effect of correction of acidosis in chronic renal failure (CRF) was determined from the kinetics of infused L-[1-13C]leucine. Nine CRF patients were studied before (acid) and after two 4-wk treatment periods of sodium bicarbonate (NaHCO3) and sodium chloride (NaCl) (pH: acid 7.31 +/- 0.01, NaHCO3 7.38 +/- 0.01, NaCl 7.30 +/- 0.01). Leucine appearance from body protein (PD), leucine disappearance into body protein (PS) and leucine oxidation (O) decreased significantly with correction of acidosis (PD: acid 122.4 +/- 6.1, NaHCO3 88.3 +/- 6.9, NaCl 116.2 +/- 9.1 mumol.kg-1.h-1, acid vs. NaHCO3 P < 0.01, NaHCO3 vs. NaCl P < 0.01, acid vs. NaCl NS; PS: acid 109.4 +/- 5.6, NaHCO3 79.0 +/- 6.3, NaCl 101.3 +/- 7.7 mumol.kg-1.h-1, acid vs. NaHCO3 P < 0.01, NaHCO3 vs. NaCl P < 0.01, acid vs. NaCl NS; O: acid 13.0 +/- 1.2, NaHCO3 9.2 +/- 0.9, NaCl 15.0 +/- 1.9 mumol.kg-1.h-1, acid vs. NaHCO3 P < 0.05, NaHCO3 vs. NaCl P < 0.01, acid vs. NaCl NS). There were no significant changes in plasma amino acid concentrations. These results confirm that correction of acidosis in chronic renal failure removes a potential catabolic factor.

Abnormalities in Amino Acid Metabolism in Patients with Chronic Renal Failure

2015 ◽  
pp. 11-19 ◽  
Author(s):  
Giacomo Deferrari ◽  
Giacomo Garibotto ◽  
Cristina Robaudo ◽  
Stefano Saffioti ◽  
Ernesto Paoletti ◽  
...  
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Amino Acid ◽  
Amino Acid Metabolism ◽  
Acid Metabolism

Amino Acid Tablet-Substituted Diets in the Management of Chronic Renal Failure

1974 ◽  
Vol 17 (3) ◽  
pp. 154-165 ◽  
Author(s):  
H.A. Lee ◽  
P.F. Down ◽  
E. Fowell ◽  
B.E.H. Hyne
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Amino Acid

Criteria for choosing amino acid therapy in acute renal failure

1978 ◽  
Vol 31 (10) ◽  
pp. 1841-1853 ◽  
Author(s):  
G L Blackburn ◽  
G Etter ◽  
T Mackenzie
Keyword(s):  
Renal Failure ◽  
Acute Renal Failure ◽  
Amino Acid ◽  
Acid Therapy

scholarly journals Amino acid therapy in the treatment of experimental acute renal failure in the rat

1980 ◽  
Vol 17 (1) ◽  
pp. 14-23 ◽  
Author(s):  
Donald E. Oken ◽  
F. Murphy Sprinkel ◽  
Barry B. Kirschbaum ◽  
Douglas M. Landwehr
Keyword(s):  
Renal Failure ◽  
Acute Renal Failure ◽  
Amino Acid ◽  
Acid Therapy
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