Changes in Immune Response to Sheep Red Blood Cells during Growth of Transplantable Rat Tumor

Oncology ◽  
1982 ◽  
Vol 39 (6) ◽  
pp. 396-398
Author(s):  
Eva Gerö-Ferencz ◽  
G.A. Medgyesi
Keyword(s):  
Immune Response ◽  
Red Blood Cells ◽  
Blood Cells ◽  
Sheep Red Blood Cells ◽  
Rat Tumor

scholarly journals CELLS INVOLVED IN THE IMMUNE RESPONSE

1969 ◽  
Vol 129 (4) ◽  
pp. 757-774 ◽  
Author(s):  
Nabih I. Abdou ◽  
Maxwell Richter
Keyword(s):  
Bone Marrow ◽  
Immune Response ◽  
Red Blood Cells ◽  
Blood Cells ◽  
Bone Marrow Cells ◽  
Allogeneic Bone Marrow ◽  
Red Cells ◽  
Allogeneic Bone ◽  
Sheep Red Blood Cells ◽  
Sheep Red Cells

Irradiated rabbits given allogeneic bone marrow cells from normal adult donors responded to an injection of sheep red blood cells by forming circulating antibodies. Their spleen cells were also capable of forming many plaques using the hemolysis in gel technique, and were also capable of undergoing blastogenesis and mitosis and of incorporating tritiated thymidine upon exposure to the specific antigen in vitro. However, irradiated rabbits injected with allogeneic bone marrow obtained from rabbits injected with sheep red blood cells 24 hr prior to sacrifice (primed donors) were incapable of mounting an immune response after stimulation with sheep red cells. This loss of reactivity by the bone marrow from primed donors is specific for the antigen injected, since the immune response of the irradiated recipients to a non-cross-reacting antigen, the horse red blood cell, is unimpaired. Treatment of the bone marrow donors with high-titered specific antiserum to sheep red cells for 24 hr prior to sacrifice did not result in any diminished ability of their bone marrow cells to transfer antibody-forming capacity to sheep red blood cells. The significance of these results, with respect to the origin of the antigen-reactive and antibody-forming cells in the rabbit, is discussed.

Immune response of a marsupial (Monodelphis domestica) to sheep red blood cells

1989 ◽  
Vol 13 (1) ◽  
pp. 73-78 ◽  
Author(s):  
D.A. Croix ◽  
N.K. Samples ◽  
J.L. Vandeberg ◽  
W.H. Stone
Keyword(s):  
Immune Response ◽  
Red Blood Cells ◽  
Blood Cells ◽  
Monodelphis Domestica ◽  
Sheep Red Blood Cells

scholarly journals THE PRIMARY IMMUNE RESPONSE IN MICE

1968 ◽  
Vol 127 (6) ◽  
pp. 1109-1126 ◽  
Author(s):  
Philip D. McMaster ◽  
Robert E. Franzl
Keyword(s):  
Immune Response ◽  
Lymph Nodes ◽  
Red Blood Cells ◽  
Blood Cells ◽  
Primary Immune Response ◽  
Polymorphonuclear Cells ◽  
Mesenteric Lymph Nodes ◽  
Sheep Red Blood Cells ◽  
Cellular Changes ◽  
Mesenteric Lymph

The effects of a single injection of a bacterial endotoxin on the cellular changes of a primary immune response to a standard dose of sheep red blood cells were studied in the spleens and mesenteric lymph nodes of mice. Daily histological comparisons of these organs in mice, injected with endotoxin, or with antigen, or both, showed that endotoxin given simultaneously with sheep red blood cells, as antigen, significantly enhanced all of the cellular changes that appear in the mesenteric lymph nodes and spleens of mice that form antibody when that antigen is given alone. First, in the white pulp of the spleens and cortical regions of the nodes, there appeared an early and excessive proliferation of the large pyroninophilic cells which seems to be responsible for the earliest formation of antibody, as judged by this work and that of others cited in the body of the paper. Polymorphonuclear cells invaded the spleens of these animals early after simultaneous challenge with antigen and endotoxin, and in far greater numbers than have ever been seen in mice given the same antigen without endotoxin. "Activated" germinal centers formed in the lymphoid tissue either 1 day before the appearance of antibody in the blood stream or on the same day, and they became larger than in the mice given antigen only. On the other hand, these specific and characteristic cellular changes failed to appear in mice prevented from forming any antibody at all by injections of endotoxin given 2 days before the antigenic challenge. These findings are discussed in the light provided by data from recent reports of others as well as in the light of the accompanying paper (1) which demonstrated not only the enhancement of antibody formation following simultaneous injections of antigen and endotoxin, as already known, but a totally unexpected, complete suppression of its formation when endotoxin was given 2 days before antigen.

scholarly journals Investigation of the immune status of mice during and following selective decontamination of the digestive tract

1989 ◽  
Vol 103 (2) ◽  
pp. 323-332 ◽  
Author(s):  
A. B. J. Speekenbrink ◽  
S. R. Alcock ◽  
D. M. V. Parrott
Keyword(s):  
Immune Response ◽  
Antibody Response ◽  
Red Blood Cells ◽  
Digestive Tract ◽  
Blood Cells ◽  
Cellular Response ◽  
Intensive Therapy ◽  
Selective Decontamination ◽  
Protein Antigens ◽  
Sheep Red Blood Cells

SUMMARYSelective decontamination of the digestive tract (SDD) employs oral antibiotics to eliminate aerobic Gram-negative bacilli while retaining the anaerobic flora. A combination of SDD and parenteral cefotaxime has recently been reported to strikingly reduce the incidence of infection in patients treated in an intensive therapy unit. The present study describes the effects of SDB and of cefotaxime on the immune response of mice to protein antigens. The in vivo cellular response to ovalbumin and sheep red blood cells was unchanged. However, SDD appeared to decrease the in vitro mitogenic response of spleen cells to phytohaemagglutinin, and cefotaxime similarly affected the response to Concanavalin A. The antibody response to sheep red blood cells was increased in the period after discontinuation of SDD. The antibody response was otherwise not affected. These results indicate that SDD is unlikely to have adverse effects on the immune response to protein antigens.

The Immune Response of the Chick Following Viral Vaccinations and Immunization with Sheep Red Blood Cells

1982 ◽  
Vol 26 (1) ◽  
pp. 97 ◽  
Author(s):  
A. J. van der Zijpp ◽  
J. M. Rooyakkers ◽  
B. Kouwenhoven
Keyword(s):  
Immune Response ◽  
Red Blood Cells ◽  
Blood Cells ◽  
Sheep Red Blood Cells
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