scholarly journals Immune Response to Sheep Red Blood Cells in Two Smyth Line Populations Homozygous for Different Major Histocompatibility Complex Haplotypes

1995 ◽  
Vol 74 (6) ◽  
pp. 951-956 ◽  
Author(s):  
G.P. SREEKUMAR ◽  
J.R. SMYTH ◽  
G.F. ERF
Keyword(s):  
Immune Response ◽  
Major Histocompatibility Complex ◽  
Red Blood Cells ◽  
Blood Cells ◽  
Major Histocompatibility ◽  
Sheep Red Blood Cells ◽  
Histocompatibility Complex

scholarly journals Major histocompatibility complex recombinant R13 antibody response against bovine red blood cells

2020 ◽  
Vol 99 (10) ◽  
pp. 4804-4808
Author(s):  
N.G. Wilkinson ◽  
R.T. Kopulos ◽  
L.M. Yates ◽  
W.E. Briles ◽  
R.L. Taylor
Keyword(s):  
Major Histocompatibility Complex ◽  
Antibody Response ◽  
Red Blood Cells ◽  
Blood Cells ◽  
Major Histocompatibility ◽  
Histocompatibility Complex

scholarly journals CELLS INVOLVED IN THE IMMUNE RESPONSE

1969 ◽  
Vol 129 (4) ◽  
pp. 757-774 ◽  
Author(s):  
Nabih I. Abdou ◽  
Maxwell Richter
Keyword(s):  
Bone Marrow ◽  
Immune Response ◽  
Red Blood Cells ◽  
Blood Cells ◽  
Bone Marrow Cells ◽  
Allogeneic Bone Marrow ◽  
Red Cells ◽  
Allogeneic Bone ◽  
Sheep Red Blood Cells ◽  
Sheep Red Cells

Irradiated rabbits given allogeneic bone marrow cells from normal adult donors responded to an injection of sheep red blood cells by forming circulating antibodies. Their spleen cells were also capable of forming many plaques using the hemolysis in gel technique, and were also capable of undergoing blastogenesis and mitosis and of incorporating tritiated thymidine upon exposure to the specific antigen in vitro. However, irradiated rabbits injected with allogeneic bone marrow obtained from rabbits injected with sheep red blood cells 24 hr prior to sacrifice (primed donors) were incapable of mounting an immune response after stimulation with sheep red cells. This loss of reactivity by the bone marrow from primed donors is specific for the antigen injected, since the immune response of the irradiated recipients to a non-cross-reacting antigen, the horse red blood cell, is unimpaired. Treatment of the bone marrow donors with high-titered specific antiserum to sheep red cells for 24 hr prior to sacrifice did not result in any diminished ability of their bone marrow cells to transfer antibody-forming capacity to sheep red blood cells. The significance of these results, with respect to the origin of the antigen-reactive and antibody-forming cells in the rabbit, is discussed.

Immune response differences between two inbred chicken lines identical at the major histocompatibility complex

1977 ◽  
Vol 5 (1) ◽  
pp. 253-259 ◽  
Author(s):  
Michael A. Palladino ◽  
Douglas G. Gilmour ◽  
Albert R. Scafuri ◽  
Howard A. Stone ◽  
G. Jeanette Thorbecke
Keyword(s):  
Immune Response ◽  
Major Histocompatibility Complex ◽  
Major Histocompatibility ◽  
Histocompatibility Complex

The Interaction of Antigens and Superantigens with the Human Class II Major Histocompatibility Complex Molecule HLA-DR1

1997 ◽  
Author(s):  
T. Jardetzky
Keyword(s):  
Immune Response ◽  
T Cells ◽  
Major Histocompatibility Complex ◽  
Immune System ◽  
Complex Molecule ◽  
Thymic Selection ◽  
Major Histocompatibility ◽  
Peptide Antigens ◽  
Histocompatibility Complex ◽  
Unique Specificity

The initiation and maintenance of an immune response to pathogens requires the interactions of cells and proteins that together are able to distinguish appropriate non-self targets from the myriadof self-proteins (Janeway and Bottomly, 1994). This discrimination between self and non-self is in part accomplished by three groups of proteins of the immune system that have direct and specific interactions with antigens: antibodies, T cell receptors (TcR) and major histocompatibility complex (MHC) proteins. Antibodies and TcR molecules are clonally expressed by the B and T cells of the immune system, respectively, defining each progenitor cell with a unique specificity for antigen. In these cell types both antibodies and TcR proteins undergo similar recombination events to generate a variable antigen combining site and thus produce a nearly unlimited number of proteins of different specificities. TcR molecules are further selected to recognize antigenic peptides bound to MHC proteins, during a process known as thymic selection, restricting the repertoire of T cells to the recognition of antigens presented by cells that express MHC proteins at their surface. Thymic selection of TcR and the subsequent restricted recognition of peptide-MHC complexes by peripheral T cells provides a fundamental molecular basis for the discrimination of self from non-sell and the regulation of the immune response (Allen, 1994; Nossal, 1994; von Boehmer, 1994). For example, different classes of T cells are used to recognize and kill infected cells (cytotoxic T cells) arid to provide lymphokiries that induce the niajority of soluble antibody responses of B cells (helper T cells). In contrast to the vast combinatorial and clonal diversity of antibodies and TcRs, a small set of MHC molecules is used to recognize a potentially unlimited universe of foreign peptide antigens for antigen presentation to T cells (Germain, 1994). This poses the problem of how each MHC molecule is capable of recognizing enough peptides to insure an immune response to pathogens. In addition, the specificity of the TcR interaction with MHC-peptide complexes is clearly crucial to the problem of self :non-self discrimination, with implications for both protective immunity and auto-immune disease.

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