Observations on the Synthesis of Carcinoembryonic Antigen by an Established Human Colonic Carcinoma Cell Line

Oncology ◽  
1980 ◽  
Vol 37 (5) ◽  
pp. 336-342 ◽  
Author(s):  
Benjamin Drewinko ◽  
Li- Ying Yang
Keyword(s):  
Carcinoembryonic Antigen ◽  
Cell Line ◽  
Carcinoma Cell ◽  
Carcinoma Cell Line ◽  
Colonic Carcinoma ◽  
Colonic Carcinoma Cell Line

scholarly journals Characterization of an unusual isoenzyme of N-acetyl-β-d-hexosaminidase from a human colonic carcinoma cell line

1981 ◽  
Vol 193 (1) ◽  
pp. 109-113 ◽  
Author(s):  
P M Kimball ◽  
M G Brattain ◽  
W E White
Keyword(s):  
Molecular Weight ◽  
Cell Line ◽  
Carcinoma Cell ◽  
Parental Cell ◽  
Carcinoma Cell Line ◽  
Colonic Carcinoma ◽  
Lower Molecular Weight ◽  
Parental Cell Line ◽  
Colonic Carcinoma Cell Line

A sub-line with increased metastatic ability was previously isolated from an established human colonic carcinoma cell line [Kimball & Brattain (1980) Cancer Res. 40, 1574-1579]. The separation and characterization of the isoenzymes of N-acetyl-beta-D-hexosaminidase from each cell line are reported. The parental cell line contained A and B isoenzymes. The sub-line lacked the A-isoenzyme activity and contained an atypical B isoenzyme that was thermolabile, susceptible to alkylation and of lower molecular weight.

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