Estrogen Receptors in DMBA-Induced Rat Mammary Tumors before and after Ovariectomy

Oncology ◽  
1977 ◽  
Vol 34 (4) ◽  
pp. 168-172 ◽  
Author(s):  
G. Leclercq ◽  
J.A. Heuson-Stiennon ◽  
C. Nuyens ◽  
M.C. Deboel ◽  
J.C. Heuson
Keyword(s):  
Estrogen Receptors ◽  
Mammary Tumors ◽  
Before And After

scholarly journals Decreased Size of Mammary Tumors Caused by Preoperative Treatment with Aglepristone in Female Domestic Dogs (Canis familiaris) Do Not Influence the Density of the Benign Neoplastic Tissue Measured Using Shear Wave Elastography Technique

Animals ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 527 ◽  
Author(s):  
Barbara Pieczewska ◽  
Kamila Glińska-Suchocka ◽  
Wojciech Niżański ◽  
Michał Dzięcioł
Keyword(s):  
Shear Wave ◽  
Tumor Size ◽  
Histopathological Examination ◽  
Shear Wave Elastography ◽  
Mammary Tumors ◽  
Needle Aspiration ◽  
Surgical Removal ◽  
Preoperative Treatment ◽  
Neoplastic Tissue ◽  
Before And After

Shear wave elastography (SWE) can be useful to discriminate between malignant and benign mammary tumors. In dogs with elevated progesterone levels compared to the baseline and fast-growing tumors, treatment with the use of aglepristone allows for tumor size reduction, which facilitates surgery. This study aimed to evaluate the influence of the preoperative treatment of benign mammary tumors (BMTs), performed with the use of aglepristone, on the density of the tumor tissue measured by SWE. Twelve female dogs with diagnosed BMTs and increased levels of progesterone were treated with aglepristone (Alizine, Virbac, France) at 10 mg/kg s.c. (Subcutaneous injection). twice, with a 24 h interval. The density of the tumor was evaluated by SWE before and after the treatment. The type of tumor was evaluated by fine needle aspiration cytology before treatment, and a histopathological examination was made after surgical removal, performed after the aglepristone treatment. In all the cases, a significant reduction in the mammary tumor’s size was observed following treatment, with no influence on the density of the tumor’s tissue measured by SWE. Similar studies on malignant mammary tumors are warranted to verify if in these cases, density will also be a constant parameter that is not dependent on the tumor size.

scholarly journals Anthocyanins Activate Membrane Estrogen Receptors With Nanomolar Potencies to Elicit a Nongenomic Vascular Response Via NO Production

2021 ◽  
Author(s):  
Camila Calfío ◽  
Francisca Donoso ◽  
J. Pablo Huidobro‐Toro
Keyword(s):  
Estrogen Receptor ◽  
Estrogen Receptors ◽  
Rapid Onset ◽  
No Production ◽  
Vascular Response ◽  
Selective Antagonists ◽  
Joint Application ◽  
Before And After ◽  
Estrogen Receptor Activity

Background The vascular pharmacodynamics of anthocyanins is only partially understood. To examine whether the anthocyanin‐induced vasorelaxation is related to membrane estrogen receptor activity, the role of ERα or GPER antagonism was ascertained on anthocyanins or 17‐β estradiol‐(E2) induced vasodilatations and NO production. Methods and Results The rat arterial mesenteric bed was perfused with either anthocyanins or corresponding 3‐O‐glycosides, or E2, to examine rapid concentration‐dependent vasorelaxations. The luminally accessible fraction of NO in mesenteric perfusates before and after anthocyanins or E2 administration was quantified. Likewise, NO‐DAF signal detected NO production in primary endothelial cells cultures incubated with anthocyanins or E2 in the absence and presence of ERα (ICI 182,780) or GPER (G‐36) selective antagonists. Anthocyanins or corresponding glycosides elicited, within minutes, vasodilation with nanomolar potencies; half maximal anthocyanin response reached 50% to 60% efficacy, in contrast to acetylcholine. The vasorelaxation is of rapid onset and exclusively endothelium‐dependent; NOS inhibition annulled the vasorelaxation. The delphinidin vascular response was not modified by 100 nmol/L atropine but significantly attenuated by joint application of ICI plus G‐36 (52±4.6 versus 8.5±1.5%), revealing the role of membrane estrogen receptors. Moreover, the anthocyanin or E2‐induced NO production was antagonized up to 70% by these antagonists. NO‐DAF signal elicited by anthocyanins was annulled by NOS inhibition or by ICI plus G‐36 addition. Conclusions The biomedical effect of anthocyanins or 3‐O‐glycosylates derivatives contained in naturally purple‐colored foods or berries is due to increased NO production, and not to the phytochemical's antioxidant potential, highlighting the nutraceutical role of natural products in cardiovascular diseases.

Estrogen Receptors and Hormone Responsiveness in Serially Transplanted Mammary Tumors in Rats*

2019 ◽  
pp. 85-94
Author(s):  
Chung Lee ◽  
Charmayne Jesik ◽  
Marayart Mangkornkanok ◽  
Julia Sensibar ◽  
Sin Hang Lee
Keyword(s):  
Estrogen Receptors ◽  
Mammary Tumors ◽  
Hormone Responsiveness

Comparison of levels of cytosol estrogen receptors with “arterial” and “venous” concentrations of gonadic steroids in mammary tumors

1981 ◽  
Vol 112 (1) ◽  
pp. 21-32 ◽  
Author(s):  
Joseph Duvivier ◽  
Claude Colin ◽  
Jean Hustin ◽  
Adelin Albert ◽  
Jean Lavigne ◽  
...  
Keyword(s):  
Estrogen Receptors ◽  
Mammary Tumors
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