Inhibition of Glycolytic Enzymes of Rat Liver and Hepatomas by Free Fatty Acids

Oncology ◽  
1976 ◽  
Vol 33 (5-6) ◽  
pp. 205-208 ◽  
Author(s):  
M.A. Lea ◽  
G. Weber ◽  
H.P. Morris
Keyword(s):  
Fatty Acids ◽  
Free Fatty Acids ◽  
Rat Liver ◽  
Glycolytic Enzymes

Regulation by Insulin and Free Fatty Acids of Pyruvate Dehydrogenase Activity in Perfused Rat Liver

1977 ◽  
Vol 5 (4) ◽  
pp. 1000-1001 ◽  
Author(s):  
DAVID L. TOPPING ◽  
M. ANWAR GOHEER ◽  
HALDANE G. COORE ◽  
PETER A. MAYES
Keyword(s):  
Fatty Acids ◽  
Free Fatty Acids ◽  
Dehydrogenase Activity ◽  
Rat Liver ◽  
Pyruvate Dehydrogenase ◽  
Perfused Rat Liver

scholarly journals Free Fatty Acids Produce Insulin Resistance and Activate the Proinflammatory Nuclear Factor- B Pathway in Rat Liver

Diabetes ◽  
2005 ◽  
Vol 54 (12) ◽  
pp. 3458-3465 ◽  
Author(s):  
G. Boden ◽  
P. She ◽  
M. Mozzoli ◽  
P. Cheung ◽  
K. Gumireddy ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Fatty Acids ◽  
Free Fatty Acids ◽  
Rat Liver ◽  
Nuclear Factor ◽  
Factor B

Feedback Inhibition of Key Glycolytic Enzymes in Liver: Action of Free Fatty Acids

Science ◽  
1966 ◽  
Vol 154 (3754) ◽  
pp. 1357-1360 ◽  
Author(s):  
G. Weber ◽  
H. J. H. Convery ◽  
M. A. Lea ◽  
N. B. Stamm
Keyword(s):  
Fatty Acids ◽  
Free Fatty Acids ◽  
Feedback Inhibition ◽  
Glycolytic Enzymes

Uptake and metabolism of free fatty acids by the morris 7777 hepatoma and host rat liver

Lipids ◽  
1982 ◽  
Vol 17 (8) ◽  
pp. 529-537 ◽  
Author(s):  
Richard E. Morton ◽  
Moseley Waite ◽  
V. Lynn King ◽  
Harold P. Morris
Keyword(s):  
Fatty Acids ◽  
Free Fatty Acids ◽  
Rat Liver ◽  
Uptake And Metabolism

Uncoupling activity of endogenous free fatty acids in rat liver mitochondria

1978 ◽  
Vol 56 (2) ◽  
pp. 111-116 ◽  
Author(s):  
Samuel H. P. Chan ◽  
Edward Higgins Jr.
Keyword(s):  
Fatty Acids ◽  
Fatty Acid ◽  
Free Fatty Acid ◽  
Free Fatty Acids ◽  
Rat Liver ◽  
Respiratory Control ◽  
Aging Effect ◽  
Liver Mitochondria ◽  
Rat Liver Mitochondria

Changes in the respiratory control index (RCI) and ADP:O ratio were found to be related to alterations in the free fatty acids levels of rat liver mitochondria aging in 0.25 M sucrose–Tris buffer at 0 °C. Free fatty acid levels increased with time after isolation of mitochondria while a concomitant decrease in the RCI and ADP:O ratio occurred. The changes in free fatty acid levels corresponded with the reported increasing levels of phospholipase A activity in aged mitochondrial preparations. Washing these mitochondria with sucrose buffer containing 1% defatted bovine serum albumin (BSA) counteracted the aging effect on the RCI (e.g., 2.5 to 3.5) and reduced the free fatty acid levels (e.g., 50 to 16 nmol/mg protein). This reversible phenomenon could be repeated several times during the in vitro aging at 0 °C. Use of 125I-iodinated BSA showed that approximately 5 μg BSA/mg mitochondria was adsorbed by the mitochondrial membranes during washing. These results indicate a direct correlation between the level of endogenous fatty acids and the uncoupling of mitochondrial oxidative phosphorylation. The mechanism of counteracting the aging effect by BSA involves the removal of some of the free fatty acids.

Effects of free fatty acids on carbohydrate metabolism and insulin signalling in perfused rat liver

2007 ◽  
Vol 37 (10) ◽  
pp. 774-782 ◽  
Author(s):  
C. Anderwald ◽  
B. Brunmair ◽  
K. Stadlbauer ◽  
M. Krebs ◽  
C. Fürnsinn ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Free Fatty Acids ◽  
Carbohydrate Metabolism ◽  
Rat Liver ◽  
Insulin Signalling ◽  
Perfused Rat Liver
Sign in / Sign up

Export Citation Format

Share Document