Regulation of Lipogenesis by Insulin and Free Fatty Acids in Perfused Rat Liver

1976 ◽  
Vol 4 (4) ◽  
pp. 717-717 ◽  
Author(s):  
DAVID L. TOPPING ◽  
PETER A. MAYES
Keyword(s):  
Fatty Acids ◽  
Free Fatty Acids ◽  
Rat Liver ◽  
Perfused Rat Liver

Regulation by Insulin and Free Fatty Acids of Pyruvate Dehydrogenase Activity in Perfused Rat Liver

1977 ◽  
Vol 5 (4) ◽  
pp. 1000-1001 ◽  
Author(s):  
DAVID L. TOPPING ◽  
M. ANWAR GOHEER ◽  
HALDANE G. COORE ◽  
PETER A. MAYES
Keyword(s):  
Fatty Acids ◽  
Free Fatty Acids ◽  
Dehydrogenase Activity ◽  
Rat Liver ◽  
Pyruvate Dehydrogenase ◽  
Perfused Rat Liver

Effects of free fatty acids on carbohydrate metabolism and insulin signalling in perfused rat liver

2007 ◽  
Vol 37 (10) ◽  
pp. 774-782 ◽  
Author(s):  
C. Anderwald ◽  
B. Brunmair ◽  
K. Stadlbauer ◽  
M. Krebs ◽  
C. Fürnsinn ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Free Fatty Acids ◽  
Carbohydrate Metabolism ◽  
Rat Liver ◽  
Insulin Signalling ◽  
Perfused Rat Liver

Inhibition of Glycolytic Enzymes of Rat Liver and Hepatomas by Free Fatty Acids

Oncology ◽  
1976 ◽  
Vol 33 (5-6) ◽  
pp. 205-208 ◽  
Author(s):  
M.A. Lea ◽  
G. Weber ◽  
H.P. Morris
Keyword(s):  
Fatty Acids ◽  
Free Fatty Acids ◽  
Rat Liver ◽  
Glycolytic Enzymes

scholarly journals Free Fatty Acids Produce Insulin Resistance and Activate the Proinflammatory Nuclear Factor- B Pathway in Rat Liver

Diabetes ◽  
2005 ◽  
Vol 54 (12) ◽  
pp. 3458-3465 ◽  
Author(s):  
G. Boden ◽  
P. She ◽  
M. Mozzoli ◽  
P. Cheung ◽  
K. Gumireddy ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Fatty Acids ◽  
Free Fatty Acids ◽  
Rat Liver ◽  
Nuclear Factor ◽  
Factor B

scholarly journals Rates of ketone-body formation in the perfused rat liver

1969 ◽  
Vol 112 (5) ◽  
pp. 595-600 ◽  
Author(s):  
H. A. Krebs ◽  
Patricia G. Wallace ◽  
R. Hems ◽  
R. A. Freedland
Keyword(s):  
Fatty Acids ◽  
Rat Liver ◽  
Ketone Bodies ◽  
Short Chain Fatty Acids ◽  
Diabetic Rats ◽  
Isolated Perfused Rat Liver ◽  
Perfused Liver ◽  
Perfused Rat Liver ◽  
Normal Range ◽  
Physiological Value

1. The rates of formation of acetoacetate and β-hydroxybutyrate by the isolated perfused rat liver were measured under various conditions. 2. The rates found after addition of butyrate, octanoate, oleate and linoleate were about 100μmoles/hr./g. wet wt. in the liver of starved rats. These rates are much higher than those found with rat liver slices. 3. The differences between the rates given by slices and by the perfused organ were much higher with the long-chain than with short-chain fatty acids. The increments caused by oleate and linoleate were 12 and 16 times as large in the perfused organ as in the slices, whereas the increments caused by butyrate and octanoate were about four times as large. 4. The rates of ketogenesis in the unsupplemented perfused liver of well-fed rats, and the increments caused by the addition of fatty acids, were about half of those in the liver from starved rats. 5. The value of the [β-hydroxybutyrate]/[acetoacetate] ratio of the medium was raised by octanoate, oleate and linoleate. 6. Carnitine did not significantly accelerate ketogenesis from fatty acids. 7. Oleate formed up to 82% of the expected yield of ketone bodies. 8. In the liver of alloxan-diabetic rats the endogenous rates of ketogenesis were raised, in some cases as high as in the liver from starved rats, after addition of oleate. 9. On addition of either β-hydroxybutyrate or acetoacetate to the perfusion medium the liver gradually adjusted the [β-hydroxybutyrate]/[acetoacetate] ratio towards the normal range. 10. The [β-hydroxybutyrate]/[acetoacetate] ratio of the medium was about 0·4 when slices were incubated, but near the physiological value of 2 when the liver was perfused. 11. The experiments demonstrate that for the study of ketogenesis slices are in many ways grossly inferior to the perfused liver.

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