Lethal Midline Granuloma – Wegener’s Granulomatosis

Oncology ◽  
1961 ◽  
Vol 14 (4) ◽  
pp. 304-310
Author(s):  
Danilo V. Stevanović
Keyword(s):  
Wegener’S Granulomatosis ◽  
Wegener's Granulomatosis ◽  
Lethal Midline Granuloma ◽  
Midline Granuloma

Idiopathic Midface Lesions

1978 ◽  
Vol 87 (1) ◽  
pp. 60-69 ◽  
Author(s):  
Stephen J. Wetmore ◽  
Charles E. Platz
Keyword(s):  
Wegener’S Granulomatosis ◽  
Correct Diagnosis ◽  
Wegener's Granulomatosis ◽  
Definitive Diagnosis ◽  
Lethal Midline Granuloma ◽  
Multiple Biopsies ◽  
Malignant Reticulosis ◽  
Disease Entities ◽  
Inflammatory Changes ◽  
Midline Granuloma

The term lethal midline granuloma has been used to describe a number of lesions which may present in the midface. A list of possible causes is presented and three entities, midline malignant reticulosis, Wegener's granulomatosis, and malignant lymphoma, are discussed in detail. The pathological descriptions, the clinical features, and the recommended forms of therapy are outlined. It is important to vigorously pursue the patient with a midline facial lesion until a definite tissue diagnosis is obtained. Multiple biopsies may be necessary because necrosis and nonspecific inflammatory changes may be present in various of these disease entities. The correct diagnosis is essential because the treatment of these diseases is different: Wegener's granulomatosis responds best to chemotherapy, whereas midline malignant reticulosis and lymphoma should be treated with radiation therapy if they are localized. Despite conceptual variations, most recent authors believe that these three diseases exist as separate entities, and furthermore, recommend that the term lethal midline granuloma be either dropped from the lexicon or relegated to a descriptive clinical term to be used only until a more definitive diagnosis can be made.

A case of nasal T cell lymphoma with lethal midline granuloma which is clinically indistinguishable from Wegener’s granulomatosis

1997 ◽  
Vol 7 (3) ◽  
pp. 183-188
Author(s):  
Toshihiro Nanki ◽  
Ryuji Koike ◽  
Noboru Mizushima ◽  
Hitoshi Kohsaka ◽  
Tetsuo Kubota ◽  
...  
Keyword(s):  
T Cell ◽  
Wegener’S Granulomatosis ◽  
Cell Lymphoma ◽  
Wegener's Granulomatosis ◽  
T Cell Lymphoma ◽  
Lethal Midline Granuloma ◽  
Midline Granuloma

Lethal Midline Granuloma: A Diagnostc Dilemma

2016 ◽  
Vol 8 (2) ◽  
pp. 60-61
Author(s):  
Ishwar Singh ◽  
Pankhuri Mittal
Keyword(s):  
Hodgkin Lymphoma ◽  
Paranasal Sinuses ◽  
Wegener’S Granulomatosis ◽  
Hard Palate ◽  
Upper Airway ◽  
Wegener's Granulomatosis ◽  
Lethal Midline Granuloma ◽  
Non Hodgkin Lymphoma ◽  
Heterogenous Group ◽  
Midline Granuloma

ABSTRACT Lethal midline granuloma (Stewart's syndrome, midline reticulosis) earlier was a name given to all progressive destructive lesions involving the nose, paranasal sinuses, hard palate, face, orbit, and upper airway. With the advent of immunohistochemistry, it is evident that it comprises a heterogenous group of disorders including non-Hodgkin lymphoma, Wegener's granulomatosis, and various granulomatous conditions which can often be encountered with dilemma of diagnosis. How to cite this article Mittal P, Singh I, Gupta D. Lethal Midline Granuloma: A Diagnostc Dilemma. Int J Otorhinolaryngol Clin 2016;8(2):60-61.

A case of nasal T cell lymphoma with lethal midline granuloma which is clinically indistinguishable from Wegener’s granulomatosis

1997 ◽  
Vol 7 (3) ◽  
pp. 183-188
Author(s):  
Toshihiro Nanki ◽  
Ryuji Koike ◽  
Noboru Mizushima ◽  
Hitoshi Kohsaka ◽  
Tetsuo Kubota ◽  
...  
Keyword(s):  
T Cell ◽  
Wegener’S Granulomatosis ◽  
Cell Lymphoma ◽  
Wegener's Granulomatosis ◽  
T Cell Lymphoma ◽  
Lethal Midline Granuloma ◽  
Midline Granuloma
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