Liver Enzymes Cannot Be Used to Predict Liver Damage after Global Hypoxia-Ischemia in a Neonatal Pig Model

Neonatology ◽  
2009 ◽  
Vol 96 (4) ◽  
pp. 211-218 ◽  
Author(s):  
Mathias Karlsson ◽  
Saulius Satas ◽  
Janet Stone ◽  
Helen Porter ◽  
Marianne Thoresen
Keyword(s):  
Liver Damage ◽  
Liver Enzymes ◽  
Pig Model ◽  
Hypoxia Ischemia ◽  
Neonatal Pig

Biopterin in the acute phase of hypoxia–ischemia in a neonatal pig model

2008 ◽  
Vol 30 (1) ◽  
pp. 1-6 ◽  
Author(s):  
Hiroki Fujioka ◽  
Haruo Shintaku ◽  
Hidehiko Nakanishi ◽  
Tae-Jang Kim ◽  
Satoshi Kusuda ◽  
...  
Keyword(s):  
Acute Phase ◽  
Pig Model ◽  
Hypoxia Ischemia ◽  
Neonatal Pig

Prescribing for patients with liver damage

1970 ◽  
Vol 8 (24) ◽  
pp. 93-94
Keyword(s):  
Liver Disease ◽  
Liver Damage ◽  
Enzyme Induction ◽  
Liver Enzymes ◽  
Liver Microsomes ◽  
Microsomal Enzymes ◽  
Impaired Liver ◽  
Conjugated Bilirubin

Many drugs are metabolised in the liver, and the duration and intensity of action of such drugs are increased in some patients with liver disease. However, many patients react normally to drugs, for although some mechanisms, such as the secretion of conjugated bilirubin into the bile, may be impaired, liver enzymes may continue to metabolise drugs normally. The function of liver microsomes is probably preserved because many drugs stimulate the synthesis of microsomal enzymes (enzyme induction), even in the failing liver,1 and thereby increase the metabolism of a variety of drugs. About 200 compounds have so far been shown to induce these enzymes.

scholarly journals EFFECT OF ALCOHOLISM ON LIVER FUNCTION TEST IN RURAL POPULATION IN INDIA

2020 ◽  
Vol 4 (8) ◽  
Author(s):  
Richa K Lath ◽  
Aniruddha Jibhkate
Keyword(s):  
Liver Function ◽  
Liver Function Test ◽  
Liver Damage ◽  
Total Protein ◽  
Liver Enzymes ◽  
Normal Individual ◽  
Public Health Problem ◽  
Albumin Level ◽  
Study Group ◽  
Function Test

Background: alcoholism is one of the major socioeconomic as well as public health problem in India. The problem is occurring equally in urban as well as in rural India. This study was carried out in essence of liver damage in alcoholics and alteration in the biochemical enzymes in the serum with respect to liver damage. Method: 100 alcoholics and 100 non alcoholic patients were selected from the hospital OPD. Liver function test was performed in both the study group. Liver  enzymes ALT,AST,ALP and the total protein and albumin level were compared in  the study group and controls. Results: The results showed there is significant increase in the liver enzymes ALT,AST,ALP in the alcoholic patients as compared to normal individual and significant fall in concentration of the total protein and albumin level in the alcoholics. Keywords: Alcoholics, liver function test

Whole body hypothermia using a portable cooling unit in a neonatal pig model: Implications for transport

2010 ◽  
Vol 3 (1) ◽  
pp. 15-20
Author(s):  
Eric Rabenstein ◽  
Melissa Tyree ◽  
Daniel Dirnberger ◽  
Robert DiGeronimo
Keyword(s):  
Pig Model ◽  
Whole Body ◽  
Cooling Unit ◽  
Neonatal Pig

Liver Enzymes as Predictors of Liver Damage Due to Blunt Abdominal Trauma in Children

2002 ◽  
Vol 95 (2) ◽  
pp. 203-206 ◽  
Author(s):  
SUBHASH R. PURANIK ◽  
JANICE S. HAYES ◽  
JULIE LONG ◽  
MARIA MATA
Keyword(s):  
Liver Damage ◽  
Abdominal Trauma ◽  
Blunt Abdominal Trauma ◽  
Liver Enzymes

scholarly journals Effects of lactulose and silymarin on liver enzymes in cirrhotic rats

2017 ◽  
Vol 95 (5) ◽  
pp. 522-529 ◽  
Author(s):  
Mozhgan Ghobadi Pour ◽  
Naser Mirazi ◽  
Hojjatollah Alaei ◽  
Shirin Moradkhani ◽  
Ziba Rajaei ◽  
...  
Keyword(s):  
Liver Regeneration ◽  
Liver Enzyme ◽  
Liver Damage ◽  
Rat Model ◽  
Liver Diseases ◽  
Liver Enzymes ◽  
Subsequent Withdrawal

Silymarin, a mixture of antihepatotoxic flavonolignans used in the treatment of liver diseases, and lactulose, a nonabsorbable synthetic disaccharide, were investigated to analyze their probable synergic and healing effects in a hepatic cirrhotic rat model. Liver damage was induced by the administration and subsequent withdrawal of thioacetamide. The significant decrease in liver enzymes and malondialdehyde levels confirmed the curative effects of silymarin and lactulose. In the silymarin + lactulose group, liver enzyme and malondialdehyde levels were significantly reduced compared with those in the thioacetamide group. All treatments led to liver regeneration and triggered enhanced regeneration. Silymarin and lactulose alone or in combination have potent curative effects and reduce thioacetamide-induced liver damage.

Placenta-derived CD95 ligand causes liver damage in hemolysis, elevated liver enzymes, and low platelet count syndrome

2004 ◽  
Vol 126 (3) ◽  
pp. 849-858 ◽  
Author(s):  
Susanne Strand ◽  
Dennis Strand ◽  
Rudolf Seufert ◽  
Amrit Mann ◽  
Johannes Lotz ◽  
...  
Keyword(s):  
Platelet Count ◽  
Liver Damage ◽  
Liver Enzymes ◽  
Cd95 Ligand ◽  
Elevated Liver Enzymes ◽  
Low Platelet Count

scholarly journals Antioxidant and Hepatoprotective Potentials of Lasimorpha senegalensis Schott Leaf Extract on Carbon Tetrachloride-induced Liver Damage in Rats

2020 ◽  
pp. 70-78
Author(s):  
Chinyere Blessing Chigor ◽  
Felix Ifeanyi Nwafor ◽  
Edith Ugwuja ◽  
Chisimdi S. Obi
Keyword(s):  
Liver Damage ◽  
Leaf Extract ◽  
Liver Enzymes ◽  
Radical Scavenging Activity ◽  
Research Work ◽  
Radical Scavenging ◽  
Albino Rats ◽  
Endogenous Antioxidants ◽  
Wistar Albino Rats

Aims: The present study assessed the antioxidant and hepatoprotective potentials of the methanolic leaf extract of Lasimorpha senegalensis – a medicinal plant used by the indigenous people of Nigeria to treat hepatitis and feverish conditions. Place and Duration of Study: The research work was conducted in the Department of Pharmacognosy and Environmental Medicine and Department of Plant Science and Biotechnology, both in the University of Nigeria, Nsukka, from May to August, 2019. Methodology: Phytochemical analyses and acute toxicity study of the sample followed standard procedures. In vitro antioxidant assay was by DPPH and H2O2 models. A total of 25 male Wistar albino rats (120 – 150 g) were grouped into five, each group with five animals. Hepatotoxicity was induced with carbontetrachloride (1 ml/kg). The treatment groups (3-5) received extract (200 and 400 mg/kg) and Silymarin (100 mg/kg). Endogenous antioxidants (superoxide dismutase, catalase, glutathione peroxidase), plasma malondialdehyde and liver enzymes (aspartate aminotransferase, alanine aminotransferase, alkaline phosphate) were determined after treatment. Results: The results showed the leaf extract had appreciable amounts of bioactive phytochemicals and free radical scavenging activity (IC50 of 0.52 mg/ml and 0.71 mg/ml for DPPH and H2O2 respectively) with no toxicity at 5000 mg/kg. The extract also elevated the endogenous antioxidants and significantly (p ≤ .05) reduced lipid peroxidase and liver enzymes. Conclusion: This report justifies the local use of this plant in the management of various diseases related to oxidative stress and liver damage.

Safety of dietary conjugated α-linolenic acid (CLNA) in a neonatal pig model

2014 ◽  
Vol 64 ◽  
pp. 119-125 ◽  
Author(s):  
Christian-Alexandre Castellano ◽  
Mélanie Plourde ◽  
Sandie I. Briand ◽  
Paul Angers ◽  
Alain Giguère ◽  
...  
Keyword(s):  
Linolenic Acid ◽  
Pig Model ◽  
Neonatal Pig

scholarly journals Dietary conjugated α-linolenic acid did not improve glucose tolerance in a neonatal pig model

2013 ◽  
Vol 53 (3) ◽  
pp. 761-768 ◽  
Author(s):  
Christian-Alexandre Castellano ◽  
Jean-Patrice Baillargeon ◽  
Mélanie Plourde ◽  
Sandie I. Briand ◽  
Paul Angers ◽  
...  
Keyword(s):  
Glucose Tolerance ◽  
Linolenic Acid ◽  
Pig Model ◽  
Neonatal Pig ◽  
Improve Glucose Tolerance
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