scholarly journals Effects of lactulose and silymarin on liver enzymes in cirrhotic rats

2017 ◽  
Vol 95 (5) ◽  
pp. 522-529 ◽  
Author(s):  
Mozhgan Ghobadi Pour ◽  
Naser Mirazi ◽  
Hojjatollah Alaei ◽  
Shirin Moradkhani ◽  
Ziba Rajaei ◽  
...  
Keyword(s):  
Liver Regeneration ◽  
Liver Enzyme ◽  
Liver Damage ◽  
Rat Model ◽  
Liver Diseases ◽  
Liver Enzymes ◽  
Subsequent Withdrawal

Silymarin, a mixture of antihepatotoxic flavonolignans used in the treatment of liver diseases, and lactulose, a nonabsorbable synthetic disaccharide, were investigated to analyze their probable synergic and healing effects in a hepatic cirrhotic rat model. Liver damage was induced by the administration and subsequent withdrawal of thioacetamide. The significant decrease in liver enzymes and malondialdehyde levels confirmed the curative effects of silymarin and lactulose. In the silymarin + lactulose group, liver enzyme and malondialdehyde levels were significantly reduced compared with those in the thioacetamide group. All treatments led to liver regeneration and triggered enhanced regeneration. Silymarin and lactulose alone or in combination have potent curative effects and reduce thioacetamide-induced liver damage.

scholarly journals COVID-19-Related Abnormal Liver Enzymes Levels: A Retrospective Study

2020 ◽  
Author(s):  
Jian-dan Qian ◽  
Yan Wang ◽  
Tian-tian Yao ◽  
Hai-chao Li ◽  
gui-qiang Wang
Keyword(s):  
Liver Injury ◽  
Liver Enzyme ◽  
Clinical Features ◽  
Liver Damage ◽  
Poor Prognosis ◽  
Liver Enzymes ◽  
Independent Predictor ◽  
The Body ◽  
Course Of Disease ◽  
Clinical Records

Abstract Background: A new disease called Coronavirus disease (COVID-19) related to SARS-CoV-2 has brought serious attacks to the world. It causes damage to multiple organ systems of the body include liver. Here we intend to shed light on the clinical features its mechanism related to liver damage which caused by COVID-19.Methods: Clinical records and laboratory results were obtained from 138 patients with laboratory-confirmed COVID-19 who were admitted to Tongji hospital, Wuhan, China from February 8, 2020 to February 18, 2020. Information on clinical features of patients with abnormal liver tests were collected for analysis.Results: Fifty-four (39.1%) and eighty-three (60.1%) patients had abnormal liver enzyme levels on admission and during the course of disease. Hepatocyte type was more common than cholestatic type abnormal. 24(17.4%) patients reached the liver injury standard in the course of disease. Patients with abnormal liver enzyme levels were more likely to be male, had higher levels of inflammation indicators, lower pulse oxygen saturation and lymphocyte count. There is a significantly higher proportion of abnormal liver enzymes levels in the patients which administrated antibiotics during hospitalization, compared with that in the ones without antibiotics therapy (56.6% vs 32.7%). Patients with liver injury was an independent predictor of a poor prognosis (p<0.0001, OR 7.774, 95%CI 2.674-22.599).Conclusions: Liver injury in COVID-19 patients was an independent predictor of a poor prognosis. The COVID-19-related abnormal liver enzymes levels may be considered as the result of secondary liver damage caused mainly by several factors. Hypoxia and disease severity account for the largest proportion.

scholarly journals All routes lead to Rome: multifaceted origin of hepatocytes during liver regeneration

2021 ◽  
Vol 10 (1) ◽  
Author(s):  
Ce Gao ◽  
Jinrong Peng
Keyword(s):  
Liver Regeneration ◽  
Progenitor Cells ◽  
Liver Damage ◽  
Liver Diseases ◽  
Cell Types ◽  
Damage Models ◽  
Diseased Liver ◽  
Metabolic Activities ◽  
Healthy Liver ◽  
Made In

AbstractLiver is the largest internal organ that serves as the key site for various metabolic activities and maintenance of homeostasis. Liver diseases are great threats to human health. The capability of liver to regain its mass after partial hepatectomy has widely been applied in treating liver diseases either by removing the damaged part of a diseased liver in a patient or transplanting a part of healthy liver into a patient. Vast efforts have been made to study the biology of liver regeneration in different liver-damage models. Regarding the sources of hepatocytes during liver regeneration, convincing evidences have demonstrated that different liver-damage models mobilized different subtype hepatocytes in contributing to liver regeneration. Under extreme hepatocyte ablation, biliary epithelial cells can undergo dedifferentiation to liver progenitor cells (LPCs) and then LPCs differentiate to produce hepatocytes. Here we will focus on summarizing the progresses made in identifying cell types contributing to producing new hepatocytes during liver regeneration in mice and zebrafish.

Apigenin protects mice against 3,5-diethoxycarbonyl-1,4-dihydrocollidine-induced cholestasis

2021 ◽  
Vol 12 (5) ◽  
pp. 2323-2334
Author(s):  
Shihong Zheng ◽  
Peichang Cao ◽  
Zequn Yin ◽  
Xuerui Wang ◽  
Yuanli Chen ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Lipid Metabolism ◽  
Liver Fibrosis ◽  
Liver Damage ◽  
Liver Diseases ◽  
Potential Drug ◽  
Abnormal Lipid Metabolism ◽  
And Oxidative Stress

Apigenin prevented the DDC-induced abnormal lipid metabolism, liver damage and liver fibrosis by reducing inflammation and oxidative stress. Apigenin might be a potential drug for the treatment of cholestatic liver diseases.

Liver Enzymes Cannot Be Used to Predict Liver Damage after Global Hypoxia-Ischemia in a Neonatal Pig Model

Neonatology ◽  
2009 ◽  
Vol 96 (4) ◽  
pp. 211-218 ◽  
Author(s):  
Mathias Karlsson ◽  
Saulius Satas ◽  
Janet Stone ◽  
Helen Porter ◽  
Marianne Thoresen
Keyword(s):  
Liver Damage ◽  
Liver Enzymes ◽  
Pig Model ◽  
Hypoxia Ischemia ◽  
Neonatal Pig

Supplementation with Fetal-Specific Factors Ameliorates Oxidative Liver Damage During Hypothermic Storage and Reperfusion in a Rat Model

2005 ◽  
Vol 3 (3) ◽  
pp. 201-209 ◽  
Author(s):  
D.V. Cherkashina ◽  
O.A. Semenchenko ◽  
V.P. Grischuk ◽  
B.J. Fuller ◽  
A. Yu. Petrenko
Keyword(s):  
Liver Damage ◽  
Rat Model ◽  
Specific Factors ◽  
Hypothermic Storage

Prescribing for patients with liver damage

1970 ◽  
Vol 8 (24) ◽  
pp. 93-94
Keyword(s):  
Liver Disease ◽  
Liver Damage ◽  
Enzyme Induction ◽  
Liver Enzymes ◽  
Liver Microsomes ◽  
Microsomal Enzymes ◽  
Impaired Liver ◽  
Conjugated Bilirubin

Many drugs are metabolised in the liver, and the duration and intensity of action of such drugs are increased in some patients with liver disease. However, many patients react normally to drugs, for although some mechanisms, such as the secretion of conjugated bilirubin into the bile, may be impaired, liver enzymes may continue to metabolise drugs normally. The function of liver microsomes is probably preserved because many drugs stimulate the synthesis of microsomal enzymes (enzyme induction), even in the failing liver,1 and thereby increase the metabolism of a variety of drugs. About 200 compounds have so far been shown to induce these enzymes.

Hepatocorbidity in psoriasis

2021 ◽  
pp. 7-11
Author(s):  
M. A. Koroleva
Keyword(s):  
Diabetes Mellitus ◽  
Psoriatic Arthritis ◽  
Mental Disorders ◽  
Cardiovascular System ◽  
Liver Damage ◽  
Liver Diseases ◽  
Hepatobiliary System ◽  
Immunological Mechanisms ◽  
Bowel Diseases ◽  
Comorbid Diseases

Тhe well-known manifestations in psoriasis include psoriatic arthritis and psoriasis of the nails, however, at present, other conditions comorbid to psoriasis have begun to be actively studied: such as liver diseases, diabetes mellitus, diseases of the cardiovascular system, obesity, mental disorders, inflmmatory bowel diseases. and joints. In addition to similar immunological mechanisms, genes have been found that are common to psoriasis and the comorbid diseases associated with it. The article provides data on dysfunctions of the hepatobiliary system in patients with psoriasis. The article reveals the results of studies conducted by foreign and domestic authors, which have shown signifiant relationships in the severity of liver damage in psoriasis.

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