In vivo Platelet Release Reaction in Patients with Heart Valve Prosthesis

1980 ◽  
Vol 9 (5) ◽  
pp. 263-275
Author(s):  
G. Cella ◽  
L. Schivazappa ◽  
A. Casonato ◽  
L.G. Molaro ◽  
A. Girolami ◽  
...  
Keyword(s):  
Heart Valve ◽  
Heart Valve Prosthesis ◽  
Valve Prosthesis ◽  
Release Reaction ◽  
Platelet Release

scholarly journals Design, development, testing at ISO standards and in vivo feasibility study of a novel polymeric heart valve prosthesis

2020 ◽  
Vol 8 (16) ◽  
pp. 4467-4480
Author(s):  
Joanna R. Stasiak ◽  
Marta Serrani ◽  
Eugenia Biral ◽  
James V. Taylor ◽  
Azfar G. Zaman ◽  
...  
Keyword(s):  
Heart Valve ◽  
Feasibility Study ◽  
Heart Valve Prosthesis ◽  
Valve Prosthesis ◽  
Design Development ◽  
Iso Standards ◽  
Bench Testing ◽  
Bioprosthetic Valves

A novel polymeric heart valve shows durability equivalent to 25 years in accelerated bench testing, in vitro hydrodynamics equivalent to existing bioprosthetic valves; and good performance in a small acute feasibility study in sheep.

In Vivo Evaluation of the Lillehei-Kaster Heart Valve Prosthesis

1976 ◽  
Vol 22 (3) ◽  
pp. 213-220 ◽  
Author(s):  
U. Sigwart ◽  
H. Schmidt ◽  
U. Gleichmann ◽  
H.G. Borst
Keyword(s):  
Heart Valve ◽  
Heart Valve Prosthesis ◽  
Valve Prosthesis ◽  
In Vivo Evaluation

In-vivo Evaluation of a Novel Surgical Heart Valve Prosthesis Designed to Be Durable, Anticoagulant-free and Silent

2021 ◽  
Vol 5 (sup1) ◽  
pp. 2-2
Author(s):  
Bart Meuris ◽  
Lucas Van Hoof ◽  
Wilm Decré ◽  
Marie Lamberigts ◽  
Tom Langenaeken ◽  
...  
Keyword(s):  
Heart Valve ◽  
Heart Valve Prosthesis ◽  
Valve Prosthesis ◽  
In Vivo Evaluation

scholarly journals In vivo experimental assessment of polytetrafluoroethylene trileaflet heart valve prosthesis

1990 ◽  
Vol 99 (6) ◽  
pp. 1074-1081 ◽  
Author(s):  
Francisco Nistal ◽  
Virginio García-Martínez ◽  
Emilio Arbe ◽  
Dolores Fernàndez ◽  
Edurne Artiñano ◽  
...  
Keyword(s):  
Heart Valve ◽  
Heart Valve Prosthesis ◽  
Valve Prosthesis ◽  
Experimental Assessment

scholarly journals Correction: Design, development, testing at ISO standards and in vivo feasibility study of a novel polymeric heart valve prosthesis

2020 ◽  
Vol 8 (16) ◽  
pp. 4639-4639
Author(s):  
Joanna R. Stasiak ◽  
Marta Serrani ◽  
Eugenia Biral ◽  
James V. Taylor ◽  
Azfar G. Zaman ◽  
...  
Keyword(s):  
Heart Valve ◽  
Feasibility Study ◽  
Heart Valve Prosthesis ◽  
Valve Prosthesis ◽  
Design Development ◽  
Iso Standards

Correction for ‘Design, development, testing at ISO standards and in vivo feasibility study of a novel polymeric heart valve prosthesis’ by Joanna R. Stasiak et al., Biomater. Sci., 2020, DOI: 10.1039/d0bm00412j.

Biological heart valve prosthesis in patients requiring chronic dialysis

2009 ◽  
Vol 56 (S 01) ◽  
Author(s):  
A Böning ◽  
S Haberer ◽  
UP Rosendahl ◽  
I Florath ◽  
JC Ennker
Keyword(s):  
Heart Valve ◽  
Chronic Dialysis ◽  
Heart Valve Prosthesis ◽  
Valve Prosthesis

Release, Aggregation and Lysis of Human Platelets by Antilymphocyte Globulin and Antiplatelet Serum

1976 ◽  
Vol 36 (02) ◽  
pp. 411-423 ◽  
Author(s):  
Nicholas Lekas ◽  
J. C Rosenberg
Keyword(s):  
Platelet Aggregation ◽  
Gamma Globulin ◽  
Human Platelets ◽  
Plasma Medium ◽  
Release Reaction ◽  
Clinical Events ◽  
Thrombotic Complications ◽  
Platelet Release ◽  
Free Media

SummaryHuman platelets labeled with 51Cr were used to determine the contribution made by platelet lysis to the platelet release reaction and platelet aggregation induced by rabbit antihuman platelet serum (APS) and equine antihuman thymocyte globulin (ATG). Platelets were tested in both plasma (PRP) and non-plasma containing media. Antibodies directed against platelets, either as APS or ATG, induced significant amounts of platelet release and aggregation, as well as some degree of lysis, in the absence of complement. The presence of complement increased platelet lysis and aggregation, but not the release reaction. Non-immune horse gamma globulin produced different responses depending upon whether platelets were investigated in PRP or non-plasma containing media. Aggregation was seen in the latter but not the former. These differences can be explained by the presence of plasma components which prevent non-specific immune complexes from causing platelet aggregation. Since platelets in vivo are always in a plasma medium, one must be wary of utilizing data from platelet studies in synthetic plasma-free media as the basis of explaining clinical events. These observations demonstrate at least two, and possibly three, different mechanisms whereby ATG could activate platelets causing thrombotic complications and thrombocytopenia, i.e., via 1) specific and, 2) non-specific non-lytic pathways and 3) a lytic pathway.

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