Adenovirus-Mediated Gene Transfer into Injured Arteries: Quantitative Analysis of Repeated Administration

Gerontology ◽  
1996 ◽  
Vol 42 (1) ◽  
pp. 25-36 ◽  
Author(s):  
Hikaru Ueno
Keyword(s):  
Quantitative Analysis ◽  
Gene Transfer ◽  
Repeated Administration

scholarly journals Environmental and genetic determinants of plasmid mobility in pathogenic Escherichia coli

2020 ◽  
Vol 6 (4) ◽  
pp. eaax3173 ◽  
Author(s):  
Jonathan H. Bethke ◽  
Adam Davidovich ◽  
Li Cheng ◽  
Allison J. Lopatkin ◽  
Wenchen Song ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Antibiotic Resistance ◽  
Quantitative Analysis ◽  
Gene Transfer ◽  
Horizontal Gene Transfer ◽  
Genomic Analysis ◽  
Genetic Determinants ◽  
Incompatibility Group ◽  
Bacterial Populations ◽  
Pathogenic Escherichia Coli

Plasmids are key vehicles of horizontal gene transfer (HGT), mobilizing antibiotic resistance, virulence, and other traits among bacterial populations. The environmental and genetic forces that drive plasmid transfer are poorly understood, however, due to the lack of definitive quantification coupled with genomic analysis. Here, we integrate conjugative phenotype with plasmid genotype to provide quantitative analysis of HGT in clinical Escherichia coli pathogens. We find a substantial proportion of these pathogens (>25%) able to readily spread resistance to the most common classes of antibiotics. Antibiotics of varied modes of action had less than a 5-fold effect on conjugation efficiency in general, with one exception displaying 31-fold promotion upon exposure to macrolides and chloramphenicol. In contrast, genome sequencing reveals plasmid incompatibility group strongly correlates with transfer efficiency. Our findings offer new insights into the determinants of plasmid mobility and have implications for the development of treatments that target HGT.

scholarly journals Quantitative Analysis of Repeat Adenovirus-Mediated Gene Transfer Into Injured Canine Femoral Arteries

1995 ◽  
Vol 15 (12) ◽  
pp. 2246-2253 ◽  
Author(s):  
Hikaru Ueno ◽  
Jian-Jun Li ◽  
Hideharu Tomita ◽  
Hiroaki Yamamoto ◽  
Yan Pan ◽  
...  
Keyword(s):  
Quantitative Analysis ◽  
Gene Transfer ◽  
Femoral Arteries

Quantitative analysis of horizontal gene transfer in complex systems

2021 ◽  
Vol 62 ◽  
pp. 103-109
Author(s):  
Jenifer Moralez ◽  
Karolina Szenkiel ◽  
Kerry Hamilton ◽  
Amy Pruden ◽  
Allison J Lopatkin
Keyword(s):  
Quantitative Analysis ◽  
Gene Transfer ◽  
Horizontal Gene Transfer ◽  
Complex Systems

An Improved Quantitative Image Analyser

1977 ◽  
Vol 35 ◽  
pp. 226-227
Author(s):  
J.P. Fallon ◽  
P.J. Gregory ◽  
C.J. Taylor
Keyword(s):  
Feature Extraction ◽  
Quantitative Analysis ◽  
Frequency Content ◽  
General Sense ◽  
Physical Measurements ◽  
Quantitative Image ◽  
Image Analyser ◽  
Automatic Methods ◽  
Quantitative Results

Quantitative image analysis systems have been used for several years in research and quality control applications in various fields including metallurgy and medicine. The technique has been applied as an extension of subjective microscopy to problems requiring quantitative results and which are amenable to automatic methods of interpretation.Feature extraction. In the most general sense, a feature can be defined as a portion of the image which differs in some consistent way from the background. A feature may be characterized by the density difference between itself and the background, by an edge gradient, or by the spatial frequency content (texture) within its boundaries. The task of feature extraction includes recognition of features and encoding of the associated information for quantitative analysis.Quantitative Analysis. Quantitative analysis is the determination of one or more physical measurements of each feature. These measurements may be straightforward ones such as area, length, or perimeter, or more complex stereological measurements such as convex perimeter or Feret's diameter.

Nucleolar Segregation and Chronic Methanol Intoxication

1969 ◽  
Vol 27 ◽  
pp. 360-361
Author(s):  
Julio H. Garcia ◽  
Janice P. Van Zandt
Keyword(s):  
Body Weight ◽  
Methyl Alcohol ◽  
Rhesus Monkeys ◽  
Repeated Administration ◽  
Serum Levels ◽  
Methanol Intoxication ◽  
Intragastric Tube ◽  
Nucleolar Segregation

Repeated administration of methyl alcohol to Rhesus monkeys (Maccaca mulata) by intragastric tube resulted in ultrastructural abnormalities of hepatocytes, which persisted in one animal twelve weeks after discontinuation of the methyl alcohol regime. With dosages ranging between 3.0 to 6.0 gms. of methanol per kg. of body weight, the serum levels attained within a few hours averaged approximately 475 mg. per cent.

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