Diffusing Capacity in Healthy Elderly Chinese

Gerontology ◽  
1989 ◽  
Vol 35 (5-6) ◽  
pp. 315-322 ◽  
Author(s):  
J. Woo ◽  
J. Pang
Keyword(s):  
Diffusing Capacity ◽  
Healthy Elderly ◽  
Elderly Chinese

scholarly journals Protein Requirements of Elderly Chinese Adults Are Higher than Current Recommendations

2020 ◽  
Vol 150 (5) ◽  
pp. 1208-1213 ◽  
Author(s):  
Deqian Mao ◽  
Fengge Chen ◽  
Rui Wang ◽  
Ping Bai ◽  
Yanhong Zhang ◽  
...  
Keyword(s):  
Amino Acid ◽  
Healthy Adult ◽  
The Elderly ◽  
Acid Oxidation ◽  
Adult Women ◽  
Chinese Adults ◽  
Amino Acid Oxidation ◽  
Protein Requirements ◽  
Healthy Elderly ◽  
Elderly Chinese

ABSTRACT Background Due to a lack of research data on the protein requirements of the elderly in China, the estimated average requirement (EAR) and the recommended nutrient intake (RNI) of protein in the elderly remain the same as those in young and middle-aged people at 0.98 g/(kg·d). Objective The objective of this study was to determine the protein requirements of healthy Chinese adults >65y old through use of the indicator amino acid oxidation (IAAO) method. Methods Seven healthy adult men and 7 healthy adult women participated in the study, with protein intakes ranging from 0.3 to 1.8 g/(kg·d). The diets were isocaloric and provided energy at a 1.5 resting energy expenditure. Protein was given based on the lactalbumin. Phenylalanine and tyrosine were added to protein doses of 0.3–1.5 g/kg according to the highest dose of protein content [1.8 g/(kg·d)]. Phenylalanine and tyrosine concentrations were kept constant at each protein dose. The mean protein requirement was determined by applying a nonlinear mixed-effects model analysis to the F13CO2, which identified a breakpoint in F13CO2 in response to graded amounts of protein. This trial was registered with the Chinese clinical trial registry as ChiCTR-BOC-17010930. Results Protein EAR and RNI for healthy elderly Chinese adults were determined to be 0.91 and 1.17 g/(kg·d), respectively, based on the indicator amino acid oxidation technique. Conclusions The estimates of protein requirements for Chinese adults >65 y in the present study are 3.4% and 19.4% higher than the current estimated requirements, 0.88 g/(kg·d) for EAR and 0.98 g/(kg·d) for RNI.

scholarly journals Executive functioning in healthy elderly Chinese people

2007 ◽  
Vol 22 (4) ◽  
pp. 501-511 ◽  
Author(s):  
H LIN ◽  
R CHAN ◽  
L ZHENG ◽  
T YANG ◽  
Y WANG
Keyword(s):  
Executive Functioning ◽  
Chinese People ◽  
Healthy Elderly ◽  
Elderly Chinese

Safety, pharmacokinetics and pharmacodynamics of single doses of rivaroxaban – an oral, direct factor Xa inhibitor – in elderly Chinese subjects

2010 ◽  
Vol 103 (01) ◽  
pp. 234-241 ◽  
Author(s):  
Ji Jiang ◽  
Yufang Hu ◽  
Jianyan Zhang ◽  
Jueling Yang ◽  
Wolfgang Mueck ◽  
...  
Keyword(s):  
Dose Range ◽  
Plasma Concentrations ◽  
Factor Xa ◽  
Maximum Plasma ◽  
Direct Factor ◽  
Dose Escalation Study ◽  
Healthy Elderly ◽  
Elderly Chinese ◽  
Dose Dependent ◽  
Chinese Subjects

SummaryRivaroxaban is a novel, oral, direct factor Xa (FXa) inhibitor for the prevention and treatment of thromboembolic disorders. The aim of this study was to investigate the safety, pharmacokinetics (PK) and pharmacodynamics (PD) of rivaroxaban in healthy, elderly Chinese subjects. In this single-centre, single-blind, placebo-controlled, parallel-group, dose-escalation study, 79 subjects, aged 59–74 years (mean 62.8), were randomised to receive once-daily oral doses of rivaroxaban 5, 10, 20, 30 or 40 mg. Rivaroxaban was well tolerated: there was a low incidence of treatment-emergent adverse events and all events were of mild intensity. Rivaroxaban was absorbed rapidly, reaching maximum plasma concentrations within 2–4 hours. The PK of rivaroxaban were dose dependent over the dose range tested. Maximal inhibition of FXa occurred 2–3 hours after dosing and returned to baseline after 24–48 hours, reflecting rivaroxaban plasma concentrations. Inhibition of FXa was associated with dose-dependent effects on global clotting tests. There were no clinically relevant differences in rivaroxaban plasma concentrations between male and female subjects. In conclusion, rivaroxaban was well tolerated and was found to have predictable PK and PD in healthy, elderly Chinese subjects.

Cardiovascular risk-associated allele frequencies for 15 genes in healthy elderly French and Chinese

2005 ◽  
Vol 43 (8) ◽  
Author(s):  
Yongjing Xia ◽  
Larry Baum ◽  
C. P. Pang ◽  
Gérard Siest ◽  
Sophie Visvikis
Keyword(s):  
Leukocyte Adhesion ◽  
Genetic Variations ◽  
French Population ◽  
Successful Ageing ◽  
Allelic Frequencies ◽  
Healthy Elderly ◽  
Elderly Chinese ◽  
Lipid Metabolism Genes ◽  
Two Populations ◽  
Ageing Populations

AbstractIn order to investigate possible ethnic differences in genetic and environmental determinants, we investigated several cardiovascular disease-associated genetic variations in successful ageing populations of France (Nancy) and China (Hong Kong). Allelic frequencies of these genetic variations were compared between healthy elderly Chinese (n=103) and French populations (n=100). A multi-locus assay was used to genotype 15 genes for 29 biallelic sites, genes implicated in lipid and homocysteine metabolism, thrombosis, leukocyte adhesion, and blood pressure regulation. For most of the candidate markers within lipid metabolism genes, the less frequent alleles were more common in the Chinese population compared with the French population, while the less frequent alleles of the majority of the other markers were detected only or more commonly in the French population. In conclusion, polymorphisms in 13 genes exhibited statistically significant differences in allelic frequencies between the two populations. Since the two populations were selected as examples of successful ageing, we could hypothesise that genetic factors that could play a role in a successful ageing process may be different between the two populations.

scholarly journals Spirometry in healthy elderly Chinese.

Thorax ◽  
1988 ◽  
Vol 43 (8) ◽  
pp. 617-620 ◽  
Author(s):  
J Woo ◽  
J Pang
Keyword(s):  
Healthy Elderly ◽  
Elderly Chinese

Psychophysiological Responses to Stress Related to Anxiety in Healthy Aging

2019 ◽  
Vol 33 (3) ◽  
pp. 188-197 ◽  
Author(s):  
Roberta Adorni ◽  
Agostino Brugnera ◽  
Alessia Gatti ◽  
Giorgio A. Tasca ◽  
Kaoru Sakatani ◽  
...  
Keyword(s):  
Healthy Aging ◽  
Near Infrared ◽  
Response Times ◽  
Cognitive Resources ◽  
Stressful Condition ◽  
Healthy Elderly ◽  
Situational Stress ◽  
Anxiety Response ◽  
Nirs Signal ◽  
Psychophysiological Correlates

Abstract. The aim of the study was to explore the effects of situational stress and anxiety in a group of healthy elderly, both in terms of psychophysiological correlates and cognitive performance. Eighteen participants ( Mage = 70 ± 6.3; range 60–85) were assessed for anxiety and were instructed to perform a computerized math task, under both a stressful and a control condition, while near-infrared spectroscopy (NIRS) signal and electrocardiography (ECG) were recorded. NIRS results evidenced an increased activation of right PFC during the entire procedure, even if effect sizes between left and right channels were larger during the experimental condition. The amount of right activation during the stressful condition was positively correlated with anxiety. Response times (RTs) were slower in more anxious than in less anxious individuals, both during the control and stressful conditions. Accuracy was lower in more anxious than in less anxious individuals, only during the stressful condition. Moreover, heart rate (HR) was not modulated by situational stress, nor by anxiety. Overall, the present study suggests that in healthy elderly, anxiety level has a significant impact on cerebral responses, and both on the amount of cognitive resources and the quality of performance in stressful situations.

Quantitative aspects of glucose production and metabolism in healthy elderly subjects

Diabetes ◽  
1982 ◽  
Vol 31 (3) ◽  
pp. 203-211 ◽  
Author(s):  
J. J. Robert ◽  
J. C. Cummins ◽  
R. R. Wolfe ◽  
M. Durkot ◽  
D. E. Matthews ◽  
...  
Keyword(s):  
Glucose Production ◽  
Elderly Subjects ◽  
Healthy Elderly ◽  
Healthy Elderly Subjects
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