scholarly journals Reference Intervals of Fibrosis Index Based on Four Indicators in Healthy Elderly Chinese

2016 ◽  
Vol 30 (5) ◽  
pp. 645-648 ◽  
Author(s):  
Guo-Ming Zhang ◽  
Yong-Jie Xia
Gerontology ◽  
1989 ◽  
Vol 35 (5-6) ◽  
pp. 315-322 ◽  
Author(s):  
J. Woo ◽  
J. Pang

2020 ◽  
Vol 150 (5) ◽  
pp. 1208-1213 ◽  
Author(s):  
Deqian Mao ◽  
Fengge Chen ◽  
Rui Wang ◽  
Ping Bai ◽  
Yanhong Zhang ◽  
...  

ABSTRACT Background Due to a lack of research data on the protein requirements of the elderly in China, the estimated average requirement (EAR) and the recommended nutrient intake (RNI) of protein in the elderly remain the same as those in young and middle-aged people at 0.98 g/(kg·d). Objective The objective of this study was to determine the protein requirements of healthy Chinese adults >65y old through use of the indicator amino acid oxidation (IAAO) method. Methods Seven healthy adult men and 7 healthy adult women participated in the study, with protein intakes ranging from 0.3 to 1.8 g/(kg·d). The diets were isocaloric and provided energy at a 1.5 resting energy expenditure. Protein was given based on the lactalbumin. Phenylalanine and tyrosine were added to protein doses of 0.3–1.5 g/kg according to the highest dose of protein content [1.8 g/(kg·d)]. Phenylalanine and tyrosine concentrations were kept constant at each protein dose. The mean protein requirement was determined by applying a nonlinear mixed-effects model analysis to the F13CO2, which identified a breakpoint in F13CO2 in response to graded amounts of protein. This trial was registered with the Chinese clinical trial registry as ChiCTR-BOC-17010930. Results Protein EAR and RNI for healthy elderly Chinese adults were determined to be 0.91 and 1.17 g/(kg·d), respectively, based on the indicator amino acid oxidation technique. Conclusions The estimates of protein requirements for Chinese adults >65 y in the present study are 3.4% and 19.4% higher than the current estimated requirements, 0.88 g/(kg·d) for EAR and 0.98 g/(kg·d) for RNI.


2018 ◽  
Vol 42 (4) ◽  
pp. 109-120 ◽  
Author(s):  
Martin Risch ◽  
Benjamin Sakem ◽  
Lorenz Risch ◽  
Urs E. Nydegger

Abstract Reference intervals (RIs) for laboratory analyses by and large, are provided by analytical platform providers – the provenience and preanalytics of materials for the calculation of intervals often remain arcane particularly relating to the age group of donors. In an observational, prospective cohort study on 1467 healthy uniracial Caucasian residents >60 years of age, 105 frequently used lab tests were done on one blood sample. With a nonrestrictive definition of health, several pathological lab results pointing to occult disease have been found and published from SENIORLAB so far. The RIs found for hemoglobin in women went from 117.9 to 152.4 g/L (80–84 years) and in men from 124.9 to 170.6 g/L (90% confidence interval [CI]). This article lists RIs computed with SENIORLAB data for such frequently ordered analyses as platelet counts, vitamin B12 and folate, ferritin and analytes measured to estimate metabolic performance in glucose turnover. In fact, 64.5% of the cohort showed prediabetic fasting plasma glucose (FPG) and/or glycated hemoglobin (HbA1c); total serum folate levels but not red blood cell folate decreased with progressing age. As much as 66% of evaluable study participants had insufficient levels of 25(OH) vitamin D. Published reports from SENIORLAB are referenced in this article.


2017 ◽  
Vol 10 (1) ◽  
Author(s):  
Oliver Okoth Achila ◽  
Paulos Semere ◽  
Danait Andemichael ◽  
Harerta Gherezgihier ◽  
Senait Mehari ◽  
...  

1989 ◽  
Vol 50 (5) ◽  
pp. 1219-1230 ◽  
Author(s):  
Philip J Garry ◽  
William C Hunt ◽  
Dorothy J VanderJagt ◽  
Robert L Rhyne

2007 ◽  
Vol 22 (4) ◽  
pp. 501-511 ◽  
Author(s):  
H LIN ◽  
R CHAN ◽  
L ZHENG ◽  
T YANG ◽  
Y WANG

2018 ◽  
Vol 56 (3) ◽  
pp. 471-478 ◽  
Author(s):  
Maria Edvardsson ◽  
Märtha Sund-Levander ◽  
Anna Milberg ◽  
Ewa Wressle ◽  
Jan Marcusson ◽  
...  

AbstractBackground:Reference intervals are widely used as decision tools, providing the physician with information about whether the analyte values indicate ongoing disease process. Reference intervals are generally based on individuals without diagnosed diseases or use of medication, which often excludes elderly. The aim of the study was to assess levels of albumin, alanine aminotransferase (ALT), aspartate aminotransferase (AST), creatinine and γ-glutamyl transferase (γ-GT) in frail, moderately healthy and healthy elderly indivuduals.Methods:Blood samples were collected from individuals >80 years old, nursing home residents, in the Elderly in Linköping Screening Assessment and Nordic Reference Interval Project, a total of 569 individuals. They were divided into three cohorts: frail, moderately healthy and healthy, depending on cognitive and physical function. Albumin, ALT, AST, creatinine and γ-GT were analyzed using routine methods.Results:Linear regression predicted factors for 34% of the variance in albumin were activities of daily living (ADL), gender, stroke and cancer. ADLs, gender and weight explained 15% of changes in ALT. For AST levels, ADLs, cancer and analgesics explained 5% of changes. Kidney disease, gender, Mini Mental State Examination (MMSE) and chronic obstructive pulmonary disease explained 25% of the variation in creatinine levels and MMSE explained three per cent of γ-GT variation.Conclusions:Because a group of people are at the same age, they should not be assessed the same way. To interpret results of laboratory tests in elderly is a complex task, where reference intervals are one part, but far from the only one, to take into consideration.


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