Influence of Age on Biochemical Composition of the Mitral Valve Connective Tissue

Gerontology ◽  
1965 ◽  
Vol 11 (3-4) ◽  
pp. 169-178 ◽  
Author(s):  
K. Trnavský ◽  
S. Kopecký ◽  
Z. Trnavská ◽  
L. Cebecauer
Keyword(s):  
Mitral Valve ◽  
Connective Tissue ◽  
Biochemical Composition

scholarly journals CARDIAL MANIFESTATIONS OF NON-DIFFERENTIATED CONNECTIVE TISSUE DYSPLASIA AND THEIR INFLUENCE ON PREGNANCY

2021 ◽  
pp. 14-22
Author(s):  
V. Yu. DOBRIANSKA ◽  
S. M. HERYAK ◽  
L. M. MALANCHUK ◽  
M. I. SHVED ◽  
I. V. KORDA
Keyword(s):  
Mitral Valve ◽  
Connective Tissue ◽  
Ventricular Arrhythmia ◽  
Pregnant Women ◽  
Mitral Valve Prolapse ◽  
Clinical Signs ◽  
Clinical Manifestations ◽  
Adequate Treatment ◽  
Pregnancy And Childbirth ◽  
Connective Tissue Dysplasia

Among the visceral manifestations of NDST in pregnant women most often diagnosed mitral valve prolapse (20-25%) that accompanied by more cardiovascular and obstetric complications during pregnancy. It demonstrates the high clinical significance of the problem of connective tissue dysplasia with mitral valve prolaps for pregnancy and requires adequate treatment programs for prevention of complications and management of pregnant women with connective tissue dysplasia. Aim. Determination of the frequency of pregnancy pathology in women with clinical signs of NDST and MVP complicated by extrasystolic arrhythmia. Materials and methods. 138 pregnant women with MVP and concomitant signs of NDST and 54 healthy pregnant women were selected for analysis. Clinical manifestations of NDST, different variants of arrhythmias and the total number of complications of pregnancy and childbirth were evaluated. Results. In pregnant women with clinical signs of NDST and MVP complicated by extrasystolic arrhythmia, cases of frequent sinus extrasystole were significantly more often compared to frequent ventricular arrhythmia (47.8% vs. 18.1%, p<0.001) and cases of combination of frequent sinus extrasystole and ventricular arrhythmia (13.3 % vs. 1.5%, p <0.05). They significantly more often identified both symptoms of arrhythmological nature and symptoms that indicated a violation of autonomic status. The presence of NDST syndrome is more often accompanied by the development of complications of pregnancy and childbirth. These pregnant women have genetic and phenotypic risk factors for the development of pathological pregnancy and childbirth, birth trauma, disability of mother and newborn, which justifies such patients in a separate risk group for individualized programs of the prevention and treatment of visceral (cardiac) manifestations of NDST and possible complications of pregnancy and childbirth. Conclusions. 3.1% of pregnant women are diagnosed with phenotypic signs (stigma) of undifferentiated connective tissue dysplasia, and the most common visceral cardiac manifestation is mitral valve prolapse. The presence of mitral valve prolapse and extrasystolic arrhythmia in pregnant women with NDST is accompanied by significantly more frequent development of pregnancy and childbirth complications in these patients.

Clinical and epidemiological features of manifestations of Wolf – Parkinson – White syndrome in men of draft age with increased dysplastic stigmatization

2020 ◽  
Vol 22 (3) ◽  
pp. 8-11
Author(s):  
K. S. Shulenin ◽  
D. V. Cherkashin ◽  
G. G. Kutelev ◽  
V. A. Kachnov ◽  
V. S. Ivanov ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Mitral Valve ◽  
Connective Tissue ◽  
Clinical Course ◽  
Lower Number ◽  
White Syndrome ◽  
Epidemiological Features ◽  
Flat Feet ◽  
High Incidence ◽  
Constitution Type

Abstract. Clinical and epidemiological and electrocardiographic features of Wolf Parkinson White syndrome in men of military age were studied. The study was a retrospective study with a solid sample of patients. Of the 1,9056 men residents of St. Petersburg between the ages of 18 and 27, Wolf-Parkinson-White syndrome was identified in 107 (0,56%) people. The disease was asymptomatic in 38 (35,5%) patients. All identified individuals with Wolf Parkinson White syndrome, in addition to asthenic Constitution type, which was observed in 68,2% of cases, were assessed for signs of systemic connective tissue involvement. It was found that flat feet, scoliosis or kyphosis, myopia, as well as mitral valve prolapse and abnormally located chords in the left ventricle of the heart are detected in almost every second man of military age. Due to the inability to assess the presence of all signs of systemic connective tissue involvement, the isolation of specific variants of dysplastic phenotypes in patients with Wolf Parkinson White syndrome was not performed. It was found that in the presence of increased dysplastic stigmatization, the clinical course of Wolf Parkinson White syndrome is characterized by a lower number of asymptomatic cases (6,3 and 16,7%, respectively; p0,05), an increase in the frequency of paroxysmal tachyarrhythmias (81,5 and 63,1%, respectively; p0,05) and a high incidence of vegetative-vascular disorders (82,8 and 15,4%, respectively; p0,05).

scholarly journals Anterior mitral valve aneurysm perforation in a patient with preexisting aortic regurgitation

2015 ◽  
Vol 78 (4) ◽  
Author(s):  
Rodolfo Citro ◽  
Angelo Silverio ◽  
Roberto Ascoli ◽  
Antonio Longobardi ◽  
Eduardo Bossone ◽  
...  
Keyword(s):  
Heart Failure ◽  
Mitral Valve ◽  
Connective Tissue ◽  
Mitral Regurgitation ◽  
Transesophageal Echocardiography ◽  
Aortic Regurgitation ◽  
Severe Mitral Regurgitation ◽  
Connective Tissue Disorders ◽  
Threatening Condition ◽  
Life Threatening

We report the case of a 71-year-old man hospitalized for acute heart failure. Transthoracic and transesophageal echocardiography showed mitral valve aneurysm (MVA) rupture and severe mitral regurgitation. No vegetations but significant aortic regurgitation were also observed. MVA perforation is a rare life-threatening condition that typically occurs as a complication of endocarditis but may also be associated with other diseases, in particular connective tissue disorders. In the present case, the absence of such etiology suggests a possible role for of aortic regurgitation in MVA rupture secondary to a “jet lesion” mechanism.

scholarly journals P290 Differences in cardiac dimensions in mitral valve prolapse with or without Barlow phenotype

2020 ◽  
Vol 21 (Supplement_1) ◽  
Author(s):  
V Kamoen ◽  
S Calle ◽  
T De Backer ◽  
F Timmermans
Keyword(s):  
Mitral Valve ◽  
Connective Tissue ◽  
Mitral Valve Prolapse ◽  
Systolic Pressure ◽  
Connective Tissue Diseases ◽  
Left Atrial Volume ◽  
Left Ventricular ◽  
Volume Index ◽  
Left Atrial Volume Index ◽  
Ventricular Systolic Pressure

Abstract Background Mitral valve prolapse (MVP) is a common cause of chronic mitral regurgitation (MR). Barlow’s disease (BD) and fibro-elastic deficiency (FED) are two major entities of MVP affecting the connective tissue of the mitral valve, but both have a different underlying pathophysiology and phenotype. In some connective tissue diseases (CTD), it has been suggested that ventricular dysfunction occurs despite absence of MR, suggesting that CTD directly involve the myocardium. We therefore investigated whether patients with BD have different cardiac dimensions compared to FED, after correcting for MR severity grade. Methods 134 patients with MVP and chronic MR were prospectively included. MR was graded carefully by echocardiography using a multi-parametric approach. The morphology of the mitral valve prolapse was specified as definite Barlow (n = 45) or non-Barlow (n = 89; FED, flail leaflet or unspecified etiology) by two experienced echocardiographers. Results In our cohort, MR was significantly more severe in the non-Barlow group compared to typical BD group (regurgitant volume (RV) 51 vs 33 ml, p = 0.021; right ventricular systolic pressure, 40 vs 34 mmHg, p= 0.05, left atrial volume index, 51 vs 42 ml/m², p = 0.07, respectively). However, there was a trend towards higher left ventricular end-diastolic diameter index (LVEDDi, 27.7 vs 29 mm, p = 0.07) and a significantly higher end-diastolic volume index (LVEDVi, 62 vs 71 ml/m², p= 0.02) in the Barlow group, despite similar ejection fractions and much less MR in the Barlow group. This resulted in a significantly higher RV/LVEDV ratio in the non-Barlow group compared to the Barlow group (42% vs 23%, p = 0.001). Similarly, the LA volume/LVEDV ratio was significantly lower in the Barlow cohort (63 vs 79%, p= 0.026). There were no significant differences in aortic dimensions between groups. Conclusions We describe for the first time that compared to non-Barlow (mostly FED), patients with MVP due to typical Barlow disease have larger ventricular dimensions and volumes, which are disproportionate to the degree of MR. We therefore hypothesize that the connective tissue alterations in these patients may also involve the myocardium resulting in LV dilation independent of MR. Further investigation and clinical implications of these findings is mandatory.

MITRAL VALVE REPAIR WITH THE TRANSAPICAL NEOCHORD IMPLANTATION IN A PATIENT WITH MIXED CONNECTIVE TISSUE DISEASE

2019 ◽  
Vol 73 (9) ◽  
pp. 2583
Author(s):  
Carmen Maria Moldovan ◽  
Vasilis Lozos ◽  
Constantina Aggeli ◽  
Konstantinos Triantafillou ◽  
Emmanouil Vavouranakis
Keyword(s):  
Mitral Valve ◽  
Connective Tissue ◽  
Connective Tissue Disease ◽  
Mitral Valve Repair ◽  
Mixed Connective Tissue Disease ◽  
Valve Repair

Mitral valve prolapse in sickle cell disease: Manifestation of a generalized connective tissue disorder

1985 ◽  
Vol 19 (1) ◽  
pp. 1-12 ◽  
Author(s):  
Scott M. Lippman ◽  
R. Patrick Abergel ◽  
Leonard E. Ginzton ◽  
Jouni Uitto ◽  
Kouichi R. Tanaka ◽  
...  
Keyword(s):  
Mitral Valve ◽  
Sickle Cell Disease ◽  
Connective Tissue ◽  
Sickle Cell ◽  
Mitral Valve Prolapse ◽  
Connective Tissue Disorder ◽  
Cell Disease ◽  
Disease Manifestation
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