Cellular and Biochemical Characterization of the Anti-Inflammatory Effects of DuP 654 in the Arachidonic Acid Murine Skin Inflammation Model (Part 1 of 2)

1990 ◽  
Vol 3 (1) ◽  
pp. 29-34 ◽  
Author(s):  
Richard R. Harris ◽  
William M. Mackin ◽  
Douglas G. Batt ◽  
Suzanne M. Rakich ◽  
Robert J. Collins ◽  
...  
Keyword(s):  
Arachidonic Acid ◽  
Biochemical Characterization ◽  
Skin Inflammation ◽  
Inflammation Model ◽  
Anti Inflammatory

Cellular and Biochemical Characterization of the Anti-Inflammatory Effects of DuP 654 in the Arachidonic Acid Murine Skin Inflammation Model (Part 2 of 2)

1990 ◽  
Vol 3 (1) ◽  
pp. 35-40
Author(s):  
Richard R. Harris ◽  
William M. Mackin ◽  
Douglas G. Bait ◽  
Suzanne M. Rakich ◽  
Robert J. Collins ◽  
...  
Keyword(s):  
Arachidonic Acid ◽  
Biochemical Characterization ◽  
Skin Inflammation ◽  
Inflammation Model ◽  
Anti Inflammatory

scholarly journals Development and Evaluation of a Topical Anti-Inflammatory Preparation Containing Dodonaea polyandra Extract

2015 ◽  
Vol 18 (4) ◽  
pp. 578 ◽  
Author(s):  
Bradley S Simpson ◽  
Xianling Luo ◽  
Jiping Wang ◽  
Yunmei Song ◽  
David Claudie ◽  
...  
Keyword(s):  
Phase Separation ◽  
Human Skin ◽  
Dosage Form ◽  
Interleukin 1 ◽  
In Vitro Release ◽  
Skin Inflammation ◽  
Skin Model ◽  
Inflammation Model ◽  
Anti Inflammatory

Purpose: We have previously reported that the Australian Northern Kaanju (Kuuku I’yu) medicinal plant Dodonaea polyandra has anti-inflammatory activity. This is attributed largely to the presence of clerodane diterpenoids contained within the leaf resin. We envisaged developing a topical preparation to treat indications relating to skin inflammation. However, it was unknown whether the resin could be incorporated into a suitable dosage form while retaining the therapeutic value demonstrated in previous work. Therefore, the following study was undertaken to assess parameters of safety and efficacy for a prototype formulation containing the leaf resin extracted from D. polyandra. Methods: Using the assessment criteria of optimum appearance, tactile feeling, spreadability and odour, 78 different formulations were developed. Formulation stability was assessed using a centrifugal test with preparations displaying phase separation further modified or re-formulated. A prototype formulation containing 5% w/w plant resin was selected and subjected to in vitro release studies. This was quantified through HPLC analysis using two major bioactive diterpenoids as reference. The prototype formulation was tested for efficacy in a TPA-induced acute murine skin inflammation model as well as a 3D human skin model for irritancy/toxicity (Epiderm™). Results: The prototype resin cream was a chartreuse-coloured homogenous semisolid preparation that was readily spreadable upon contact with skin with no sensation of tackiness, residual greasiness, or irritation. The optimized cream showed no phase separation after 30 min centrifugation at 825 g. In the TPA-induced inflammation model, the resin formulation significantly reduced ear thickness and interleukin-1 beta levels in mouse ear tissue. The 5% w/w resin cream formulation showed no irritancy in a 3D human skin model. Conclusions: Our results demonstrate that bioactive resin from D. polyandra can be formulated into a stable and non-irritant semi-solid dosage form and reduce parameters of acute skin inflammation in vivo. This article is open to POST-PUBLICATION REVIEW. Registered readers (see “For Readers”) may comment by clicking on ABSTRACT on the issue’s contents page.

scholarly journals Casearia decandra leaves present anti-inflammatory efficacy in a skin inflammation model in mice

2020 ◽  
Vol 249 ◽  
pp. 112436 ◽  
Author(s):  
Camila Camponogara ◽  
Evelyne da Silva Brum ◽  
Bianca Vargas Belke ◽  
Thiele Faccim Brum ◽  
Roberta da Silva Jesus ◽  
...  
Keyword(s):  
Skin Inflammation ◽  
Inflammation Model ◽  
Anti Inflammatory

Biochemical Characterization of the Human Liver Cytochrome P450 Arachidonic Acid Epoxygenase Pathway

1996 ◽  
Vol 330 (1) ◽  
pp. 87-96 ◽  
Author(s):  
Darryl C. Zeldin ◽  
Cindy R. Moomaw ◽  
Nate Jesse ◽  
Kenneth B. Tomer ◽  
Jeffrey Beetham ◽  
...  
Keyword(s):  
Arachidonic Acid ◽  
Cytochrome P450 ◽  
Human Liver ◽  
Biochemical Characterization ◽  
Liver Cytochrome

scholarly journals Effects of Flavonoids from French Marigold (Florets ofTagetes patulaL.) on Acute Inflammation Model

2013 ◽  
Vol 2013 ◽  
pp. 1-5 ◽  
Author(s):  
Ken Yasukawa ◽  
Yoshimasa Kasahara
Keyword(s):  
Arachidonic Acid ◽  
Oral Administration ◽  
Topical Application ◽  
Acute Inflammation ◽  
Topical Administration ◽  
Tagetes Patula ◽  
Paw Edema ◽  
Ear Edema ◽  
Inflammation Model ◽  
Anti Inflammatory

The major components patuletin and patulitrin were isolated from French marigold (florets ofTagetes patula). Patuletin and patulitrin were found to inhibit acute inflammation in mice. Oral administration of patuletin and patulitrin significantly suppressed hind-paw edema induced by carrageenin and histamine, while topical application of patuletin and patulitrin significantly inhibited ear edema induced by 12-O-tetradecanoylphorbol-13-acetate and arachidonic acid. Thus, oral and topical administration of patuletin and patulitrin inhibited acute inflammation in mice. These results suggest the anti-inflammatory efficacy of French marigold.

scholarly journals Comprehensive, Multimodal Characterization of an Imiquimod-Induced Human Skin Inflammation Model for Drug Development

2018 ◽  
Vol 11 (6) ◽  
pp. 607-615 ◽  
Author(s):  
Tessa van der Kolk ◽  
Salma Assil ◽  
Rianne Rijneveld ◽  
Erica S. Klaassen ◽  
Gary Feiss ◽  
...  
Keyword(s):  
Drug Development ◽  
Human Skin ◽  
Skin Inflammation ◽  
Inflammation Model

Oleic acid-containing semisolid dosage forms exhibit in vivo anti-inflammatory effect via glucocorticoid receptor in a UVB radiation-induced skin inflammation model

2019 ◽  
Vol 28 (3) ◽  
pp. 773-786 ◽  
Author(s):  
Natháli Schopf Pegoraro ◽  
Camila Camponogara ◽  
Mailine Gehrcke ◽  
Laura Minussi Giuliani ◽  
Dariane Trivisiol da Silva ◽  
...  
Keyword(s):  
Oleic Acid ◽  
Glucocorticoid Receptor ◽  
Skin Inflammation ◽  
Dosage Forms ◽  
Uvb Radiation ◽  
Inflammation Model ◽  
Radiation Induced ◽  
Anti Inflammatory ◽  
Inflammatory Effect

scholarly journals 670 Characterization of a novel IL-36-induced skin inflammation model in mice

2017 ◽  
Vol 137 (5) ◽  
pp. S115
Author(s):  
Z. Su ◽  
J. Wetter ◽  
K. Salte ◽  
R. Edelmayer ◽  
A. Kannan ◽  
...  
Keyword(s):  
Skin Inflammation ◽  
Inflammation Model
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