scholarly journals Low-Intensity Pulsed Ultrasound Accelerates Osteoblast Differentiation and Promotes Bone Formation in an Osteoporosis Rat Model

Pathobiology ◽  
2009 ◽  
Vol 76 (3) ◽  
pp. 99-107 ◽  
Author(s):  
Shuliang Wu ◽  
Yumi Kawahara ◽  
Tomotaka Manabe ◽  
Kazuyuki Ogawa ◽  
Masaya Matsumoto ◽  
...  
Keyword(s):  
Bone Formation ◽  
Rat Model ◽  
Osteoblast Differentiation ◽  
Pulsed Ultrasound ◽  
Low Intensity Pulsed Ultrasound ◽  
Low Intensity

scholarly journals Low-intensity Pulsed Ultrasound Stimulation Significantly Enhances the Promotion of Bone Formation Around Dental Implants

2011 ◽  
Vol 20 (2) ◽  
pp. 139-146 ◽  
Author(s):  
Yasuhiro Nakanishi ◽  
Pao-Li Wang ◽  
Morio Ochi ◽  
Kazuyo Nakanishi ◽  
Hideki Matsubara
Keyword(s):  
Bone Formation ◽  
Dental Implants ◽  
Pulsed Ultrasound ◽  
Low Intensity Pulsed Ultrasound ◽  
Low Intensity ◽  
Ultrasound Stimulation

scholarly journals Low Intensity Pulsed Ultrasound for Bone Tissue Engineering

Micromachines ◽  
2021 ◽  
Vol 12 (12) ◽  
pp. 1488
Author(s):  
Colleen McCarthy ◽  
Gulden Camci-Unal
Keyword(s):  
Bone Formation ◽  
Bone Tissue ◽  
Mechanical Stimulation ◽  
Synergistic Effects ◽  
In Vivo Studies ◽  
Pulsed Ultrasound ◽  
Low Intensity Pulsed Ultrasound ◽  
Low Intensity

As explained by Wolff’s law and the mechanostat hypothesis, mechanical stimulation can be used to promote bone formation. Low intensity pulsed ultrasound (LIPUS) is a source of mechanical stimulation that can activate the integrin/phosphatidylinositol 3-OH kinase/Akt pathway and upregulate osteogenic proteins through the production of cyclooxygenase-2 (COX-2) and prostaglandin E2 (PGE2). This paper analyzes the results of in vitro and in vivo studies that have evaluated the effects of LIPUS on cell behavior within three-dimensional (3D) titanium, ceramic, and hydrogel scaffolds. We focus specifically on cell morphology and attachment, cell proliferation and viability, osteogenic differentiation, mineralization, bone volume, and osseointegration. As shown by upregulated levels of alkaline phosphatase and osteocalcin, increased mineral deposition, improved cell ingrowth, greater scaffold pore occupancy by bone tissue, and superior vascularization, LIPUS generally has a positive effect and promotes bone formation within engineered scaffolds. Additionally, LIPUS can have synergistic effects by producing the piezoelectric effect and enhancing the benefits of 3D hydrogel encapsulation, growth factor delivery, and scaffold modification. Additional research should be conducted to optimize the ultrasound parameters and evaluate the effects of LIPUS with other types of scaffold materials and cell types.

Low-intensity pulsed ultrasound stimulation promotes osteoblast differentiation through hedgehog signaling

2018 ◽  
Vol 119 (6) ◽  
pp. 4352-4360 ◽  
Author(s):  
Kenichi Matsumoto ◽  
Tsuyoshi Shimo ◽  
Naito Kurio ◽  
Tatsuo Okui ◽  
Soichiro Ibaragi ◽  
...  
Keyword(s):  
Hedgehog Signaling ◽  
Osteoblast Differentiation ◽  
Pulsed Ultrasound ◽  
Low Intensity Pulsed Ultrasound ◽  
Low Intensity ◽  
Ultrasound Stimulation
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