Effect of Serum Vitamin B12 Binding on Intrinsic Factor Antibody Detection in Pernicious Anaemia

1972 ◽  
Vol 47 (5) ◽  
pp. 264-268 ◽  
Author(s):  
H.A. Ghazi
Keyword(s):  
Intrinsic Factor ◽  
Serum Vitamin ◽  
Pernicious Anaemia ◽  
Antibody Detection ◽  
Vitamin B ◽  
Intrinsic Factor Antibody

scholarly journals Sensorimotor Neuropathy and Abnormal Vitamin B12 Metabolism in Early HIV Infection

1995 ◽  
Vol 22 (1) ◽  
pp. 43-46 ◽  
Author(s):  
M. Veilleux ◽  
O. Paltiel ◽  
J. Falutz
Keyword(s):  
Hiv Infection ◽  
Complete Blood Count ◽  
Clinical Stage ◽  
Intrinsic Factor ◽  
Serum Vitamin ◽  
Vitamin B ◽  
Schilling Test ◽  
Advanced Stages ◽  
Skin Responses ◽  
Intrinsic Factor Antibody

ABSTRACT:Distal sensory peripheral neuropathy (DSPN) has been reported in 5 to 75% of patients with human immunodeficiency virus (HIV) infection, particularly in advanced stages of the disease. Twenty HIV seropositive patients were studied prospectively to determine the frequency of DSPN in clinical stage II and III of the HIV infection, and to investigate the role of vitamin B12 deficiency on the frequency of DSPN in HIV patients. All patients had complete blood count, serum vitamin B12 level, anti-intrinsic factor antibody, Schilling test, and electrodiagnostic studies including nerve conduction studies and concentric needle examination in the lower extremities, and sympathetic skin responses. Only 1 patient (5%) had clinical and electrophysiological evidence of possible DSPN. Of the 6 patients with abnormal Schilling test, only one had DSPN based on distal sensory symptoms, abnormal neurological examination and electrodiagnostic studies. Evidence for possible DSPN was present in 5% of patients with early HIV infection and did not appear to be more frequent in patients with concurrent vitamin B12 deficiency.

INTRINSIC-FACTOR ANTIBODY AND GASTRIC MUCOSA IN PERNICIOUS ANÆMIA

The Lancet ◽  
1967 ◽  
Vol 289 (7488) ◽  
pp. 501-502
Author(s):  
Harriet Dige-Petersen ◽  
Paul Rødbro ◽  
Jette Howitz
Keyword(s):  
Gastric Mucosa ◽  
Intrinsic Factor ◽  
Pernicious Anaemia ◽  
Intrinsic Factor Antibody

Plasma Radioactivity following Oral Administration of 57Co-Labelled Vitamin B12

1968 ◽  
Vol 13 (12) ◽  
pp. 425-429 ◽  
Author(s):  
R. D. Finney ◽  
R. W. Payne
Keyword(s):  
Intrinsic Factor ◽  
Pernicious Anaemia ◽  
Test Dose ◽  
Normal Subjects ◽  
Vitamin B ◽  
Oral Test ◽  
Parenteral Dose ◽  
Schilling Test ◽  
Low Levels ◽  
Gastro Intestinal Tract

Levels of plasma radioactivity were measured 8 1/2 hours after an oral dose of 1 μg of 57Co-labelled vitamin B12. The oral test dose was followed after 2 hours by a large parenteral dose (1,000 μg) of non-radioactive vitamin B12. The results of this test have been compared with the results of the urinary excretion (Schilling test) in 14 normal subjects and in 14 patients suffering from pernicious anaemia (in 10 of whom the test was later repeated with added hog intrinsic factor). Very low levels of plasma radioactivity were found in patients suffering from pernicious anaemia (less than 0.21% of the administered dose per litre of plasma); much higher levels of radioactivity (more than 0.95% of administered radioactivity per litre of plasma) were found in normal subjects. Levels of plasma radioactivity approaching but not quite reaching the normal range were found in patients with pernicious anaemia when the test was repeated with the addition of hog intrinsic factor. It is concluded that this test provides a simple, rapid, semi-quantitative method of assessing the absorption of vitamin B12 from the gastro-intestinal tract. In our view, it is likely to supplant the Schilling test for routine use in a busy general hospital.

A Survey of Vitamin B12 Deficiency in an Elderly Psychiatric Population

1967 ◽  
Vol 113 (496) ◽  
pp. 241-251 ◽  
Author(s):  
R. Shulman
Keyword(s):  
Psychiatric Patients ◽  
Serum Vitamin ◽  
Vitamin B12 Deficiency ◽  
Pernicious Anaemia ◽  
Vitamin B ◽  
Cerebral Lesions ◽  
Mental Symptoms ◽  
B12 Deficiency ◽  
The Subject ◽  
Wassermann Reaction

For many years, cases of pernicious anaemia associated with mental symptoms have been described, and interest in these symptoms was renewed following the introduction of liver therapy (Richardson, 1929; Phillips, 1931). Interest later appeared to decline, so that MacDonald Holmes (1956), almost 20 years after the last important clinical review of the subject, could comment with justification that although the cerebral lesions of pernicious anaemia had been recognized for more than a century they were still much less familiar than the lesions which occurred in the spinal cord and peripheral nerves. Since then vitamin B12 deficiency as a cause of mental symptoms has given rise to increasing interest, and this is reflected in recent suggestions that serum vitamin B12 assays should be carried out routinely in psychiatric patients and might be more informative nowadays than the routine Wassermann reaction (Strachan and Henderson, 1965; Hunter and Matthews, 1965).

scholarly journals A Case of Pernicious Anaemia with Psoriasis

2020 ◽  
Vol 15 (2) ◽  
pp. 243-245
Author(s):  
Md Anisur Rahman ◽  
Most Umme Habiba Begum ◽  
Md Abdur Razzak ◽  
Jesmin Khandker
Keyword(s):  
Peripheral Neuropathy ◽  
Vitamin B12 ◽  
Atrophic Gastritis ◽  
Intrinsic Factor ◽  
Pernicious Anaemia ◽  
Autoimmune Disorder ◽  
Antibody Treatment ◽  
Autoimmune Atrophic Gastritis ◽  
Intrinsic Factor Antibody

Pernicious anaemia often poses diagnostic and therapeutic challenges to the clinician. Herein, we representing a 55 years old lady who presented with anaemia along with its classical symptoms and features of peripheral neuropathy due to Pernicious anaemia associated with Psoriasis and Arthropathy without any association of other autoimmune disorder. She had all objective evidences of autoimmune atrophic gastritis in gastric fundic biopsy and positive anti-intrinsic factor antibody. Treatment with injection vitamin B12 improved the condition rapidly. JAFMC Bangladesh. Vol 15, No 2 (December) 2019: 243-245

Autoimmune gastritis concomitant with gastric adenoma and subacute combined degeneration of the spinal cord

2021 ◽  
Vol 14 (5) ◽  
pp. e242836
Author(s):  
Masahiro Taniguchi ◽  
Gota Sudo ◽  
Yuzufumi Sekiguchi ◽  
Hiroshi Nakase
Keyword(s):  
Spinal Cord ◽  
Histopathological Examination ◽  
Intrinsic Factor ◽  
Pernicious Anaemia ◽  
Autoimmune Gastritis ◽  
Gastric Neoplasms ◽  
Gastric Body ◽  
Vitamin B ◽  
Gastric Adenoma ◽  
Subacute Combined Degeneration

A 62-year-old woman was referred to our department for further investigation of anaemia. Blood test showed macrocytic anaemia. Oesophagogastroduodenoscopy (OGD) revealed proximal-predominant gastric atrophy and flat elevated lesion in the gastric body. Several days after OGD, she complained of gait disturbance and was diagnosed with subacute combined degeneration of the spinal cord. Furthermore, laboratory tests showed positive for both anti-parietal cell and anti-intrinsic factor antibodies, as well as increased serum gastrin level and decreased pepsinogen I level, which confirmed the diagnosis of autoimmune gastritis (AIG). Anaemia and neurological symptoms were improved after vitamin B12 supplementation. Subsequently, the patient underwent gastric endoscopic submucosal dissection; histopathological examination revealed gastric adenoma. AIG can cause gastric neoplasms and vitamin B12 deficiency, with the latter resulting in pernicious anaemia and neurological disorders. These diseases are treatable but potentially life-threatening. This case highlights the importance of early diagnosis of AIG and proper management of its comorbidities.

Serum Vitamin B12 Levels in Indian Psychiatric Patients

1970 ◽  
Vol 117 (541) ◽  
pp. 699-704 ◽  
Author(s):  
V. S. Jathar ◽  
S. P. Patrawalla ◽  
D. R. Doongaji ◽  
D. V. Rege ◽  
R. S. Satoskar
Keyword(s):  
Bone Marrow ◽  
Vitamin B12 ◽  
Peripheral Blood ◽  
Psychiatric Symptoms ◽  
Psychiatric Patients ◽  
Serum Vitamin ◽  
Pernicious Anaemia ◽  
Vitamin B ◽  
Mental Symptoms ◽  
Low Serum

It is known that pernicious anaemia is sometimes associated with mental symptoms which improve following vitamin B12 therapy (Eilenberg, 1960; Holmes, 1956; Smith, 1960). Further, it has been pointed out that such mental symptoms can occur years before the development of anaemia and no definite relationship exists between them and the severity of anaemia (Smith, 1960). Cases have been described with a variety of psychiatric symptoms and low serum vitamin B12 levels without any neurological manifestation or abnormality of peripheral blood and bone marrow. Since pernicious anaemia is due to vitamin B12 deficiency it is suspected that B12 deficiency is responsible for the mental symptoms, and serum B12 assays have been advocated routinely in psychiatric patients (Strachan and Henderson, 1965; Hunter and Matthews, 1965).

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