Prenatal Cocaine Increases Dendritic Spine Density in Cortical and Subcortical Brain Regions of the Rat

2009 ◽  
Vol 31 (1-2) ◽  
pp. 71-75 ◽  
Author(s):  
Maya Frankfurt ◽  
Hoau-Yan Wang ◽  
Naydu Marmolejo ◽  
Kalindi Bakshi ◽  
Eitan Friedman
Keyword(s):  
Dendritic Spine ◽  
Brain Regions ◽  
Spine Density ◽  
Dendritic Spine Density ◽  
Subcortical Brain ◽  
Prenatal Cocaine

scholarly journals Cocaine alters dendritic spine density in cortical and subcortical brain regions of the postpartum and virgin female rat

Synapse ◽  
2011 ◽  
Vol 65 (9) ◽  
pp. 955-961 ◽  
Author(s):  
Maya Frankfurt ◽  
Kaliris Salas-Ramirez ◽  
Eitan Friedman ◽  
Victoria Luine
Keyword(s):  
Dendritic Spine ◽  
Virgin Female ◽  
Brain Regions ◽  
Female Rat ◽  
Spine Density ◽  
Dendritic Spine Density ◽  
Subcortical Brain

scholarly journals Sex differences in dendritic spine density and morphology in auditory and visual cortices in adolescence and adulthood

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Emily M. Parker ◽  
Nathan L. Kindja ◽  
Claire E. J. Cheetham ◽  
Robert A. Sweet
Keyword(s):  
Sex Differences ◽  
Dendritic Spines ◽  
Dendritic Spine ◽  
Brain Regions ◽  
Spine Density ◽  
Female Mice ◽  
Dendritic Spine Density ◽  
Layer 4 ◽  
Visual Cortices ◽  
Mushroom Spines

AbstractDendritic spines are small protrusions on dendrites that endow neurons with the ability to receive and transform synaptic input. Dendritic spine number and morphology are altered as a consequence of synaptic plasticity and circuit refinement during adolescence. Dendritic spine density (DSD) is significantly different based on sex in subcortical brain regions associated with the generation of sex-specific behaviors. It is largely unknown if sex differences in DSD exist in auditory and visual brain regions and if there are sex-specific changes in DSD in these regions that occur during adolescent development. We analyzed dendritic spines in 4-week-old (P28) and 12-week-old (P84) male and female mice and found that DSD is lower in female mice due in part to fewer short stubby, long stubby and short mushroom spines. We found striking layer-specific patterns including a significant age by layer interaction and significantly decreased DSD in layer 4 from P28 to P84. Together these data support the possibility of developmental sex differences in DSD in visual and auditory regions and provide evidence of layer-specific refinement of DSD over adolescent brain development.

Regional differences in dendritic spine density confer resilience to chronic social defeat stress

2017 ◽  
Vol 30 (2) ◽  
pp. 117-122 ◽  
Author(s):  
Youge Qu ◽  
Chun Yang ◽  
Qian Ren ◽  
Min Ma ◽  
Chao Dong ◽  
...  
Keyword(s):  
Dendritic Spine ◽  
Regional Differences ◽  
Social Defeat ◽  
Brain Regions ◽  
Control Group ◽  
Spine Density ◽  
Dendritic Spine Density ◽  
Chronic Social Defeat Stress ◽  
The Brain ◽  
Susceptible Group

ObjectiveAlthough alterations in the dendritic spine density in the brain regions may play a role in the stress-induced depression-like phenotype, the precise mechanisms are unknown. The aim was to investigate the role of spine density in the brain regions after chronic social defeat stress (CSDS).MethodsWe examined dendritic spine density in the medial prefrontal cortex (mPFC), CA1, CA3, dentate gyrus (DG) of hippocampus, nucleus accumbens (NAc), and ventral tegmental area (VTA) of susceptible and resilient mice after CSDS.ResultsSpine density in the prelimbic area of mPFC, CA3, and DG in the susceptible group, but not resilient group, was significantly lower than control group. In contrast, spine density in the NAc and VTA in the susceptible group, but not resilient group, was significantly higher than control group.ConclusionsThe results suggest that regional differences in spine density may contribute to resilience versus susceptibility in mice subjected to CSDS.

scholarly journals FMRP regulates the subcellular distribution of cortical dendritic spine density in a non-cell-autonomous manner

2021 ◽  
pp. 105253
Author(s):  
Katherine M. Bland ◽  
Adam Aharon ◽  
Eden L. Widener ◽  
M. Irene Song ◽  
Zachary O. Casey ◽  
...  
Keyword(s):  
Dendritic Spine ◽  
Subcellular Distribution ◽  
Spine Density ◽  
Dendritic Spine Density
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