Leukämie- und Tumorbehandlung mit einem Nebenalkaloid aus Colchicum autumnale (Demecolcin)

The paper describes the past and present distribution of Colchicum autumnale in the vicinity of Cracow, highlights the role of Stanisław Dembosz (who published the first locality of C. autumnale near Igołomia in 1841). Gives information about the occurrence of C. autumnale in Krzeszowice in the 19th century (reported by Bronisław Gustawicz), presents new localities noted in 2012–2014 in meadows in the north-eastern part of the Puszcza Niepołomicka forest and adjacent area (between the Vistula and Raba rivers), and gives a locality found in Cracow in 2005 (no longer extant).

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Substanzen der herbstzeitlose und ihre derivate XXXVIII. Isolierung weiterer substanzen aus den knollen der herbstzeitlose (Colchicum autumnale L.)

Collection of Czechoslovak Chemical Communications ◽

10.1135/cccc19541289 ◽

1954 ◽

Vol 19 (6) ◽

pp. 1289-1301 ◽

Cited By ~ 7

Author(s):

F. Šantavý ◽

Z. Hoščálková ◽

R. Podivínský ◽

H. Potěšilová

Keyword(s):

Colchicum Autumnale

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Substanzen der herbstzeitlose und ihre derivate XXXIV. Isolierung weiterer substanzen aus den blüten der herbstzeitlose (Colchicum autumnale L.)

Collection of Czechoslovak Chemical Communications ◽

10.1135/cccc19540805 ◽

1954 ◽

Vol 19 (4) ◽

pp. 805-816 ◽

Cited By ~ 12

Author(s):

F. Šantavý ◽

V. Mačák

Keyword(s):

Colchicum Autumnale

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Colchicine poisoning by accidental ingestion of meadow saffron (Colchicum autumnale): pathological and medicolegal aspects

Forensic Science International ◽

10.1016/s0379-0738(99)00191-7 ◽

1999 ◽

Vol 106 (3) ◽

pp. 191-200 ◽

Cited By ~ 47

Author(s):

Michael Klintschar ◽

Christine Beham-Schmidt ◽

Herbert Radner ◽

Gerald Henning ◽

Peter Roll

Keyword(s):

Accidental Ingestion ◽

Medicolegal Aspects ◽

Colchicum Autumnale ◽

Colchicine Poisoning

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Gloriosa superba and Colchicum autumnale multi-tissue transcriptome analysis for colchicine pathway and rhizome development candidate gene identification

10.21203/rs.2.9594/v1 ◽

2019 ◽

Author(s):

John Samuel Bass ◽

David R. Gang ◽

Toni M. Kutchan ◽

Ganapathy Sivakumar

Keyword(s):

Transcription Factors ◽

Biosynthetic Pathway ◽

Gloriosa Superba ◽

Colchicum Autumnale ◽

Synthetic Drugs ◽

Fundamental Information ◽

Significant Barrier ◽

Medicinal Properties ◽

Based Medicine ◽

Rhizome Development

Abstract Background The continued emergence of side-effects caused by synthetic drugs underscores the need for plant-based drugs in human medicine. Medicinal rhizomatous crops are a “goldmine for modern drugs”, and include such species as Gloriosa superba L. and Colchicum autumnale L., the producers of colchicine, a plant-based medicine. The natural isomer of bioactive colchicine is used to effectively treat major diseases such as cancer, cardiovascular disease, and gout. The medicinal properties of colchicine are well characterized, however, almost nothing is known about its biosynthesis. The paucity of information on the colchicine biosynthetic pathway is a significant barrier to biomanufacturing of this biomedicine. A comparative transcriptome study of G. superba and C. autumnale serves as a sequence resource to aid with identification of this biomedicine pathway and rhizome development genes for synthetic biotechnology toolbox, which will enable improved colchicine biomanufacturing. Result Transcriptomes of two colchicine synthesizing monocots G. superba and C. autumnale were interrogated to identify putative cDNAs encoding enzymes and transcription factors involved in the colchicine biosynthetic pathway and rhizome development. Mining of the transcriptomes using Blast2GO led to the identification from G. superba and C. autumnale, respectively, of 20 and 29 candidate colchicine biosynthetic genes N-methyltransferases, 3-O-methyltransferases, cytochrome P450s, a class that could catalyze several steps in the pathway, and N-acetyltransferases. Similarly, 19 and 15 candidate rhizome developmental genes, which belongs to several classes including GIGANTEA, CONSTANS, Phytochrome B, Sucrose Synthase), Flowering Locus T, and REVOLUTA. Likewise, about 16 and 12 transcription factors involved in regulating rhizome development and secondary metabolic pathways in rhizomes such as MADS-box, AP2-EREBP, bHLH, MYB, NAC, and WRKY were also found in G. superba and C. autumnale, respectively. Conclusion The predicted genes in G. superba and C. autumnale encode colchicine pathway enzymes that provide fundamental information for plant-based biomedicine engineering in biorhizomes and microorganisms, a potentially important area of synthetic biotechnology. Additionally, increasing our understanding of rhizome functional genomics will lead to improved colchicine biomanufacturing, and generate important knowledge that can be applied to many other medicinal plant species, allowing for the engineered production of additional biomedicines in medicinal rhizomes.

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Herbstzeitlose, Colchicum autumnale L.

Zeitschrift für Phytotherapie ◽

10.1055/a-1256-7150 ◽

2021 ◽

Vol 42 (02) ◽

pp. 111-116

Author(s):

Zilin Mo ◽

Matthias F. Melzig

Keyword(s):

Colchicum Autumnale

Zusammenfassung Colchicum autumnale L., die Herbstzeitlose, ist eine in Mitteleuropa verbreitete Pflanze, die v. a. Tropolonalkaloide wie Colchicin, Demecolcin sowie Colchicosid enthält. Der Hauptwirkstoff Colchicin verhindert die Ausbildung des zellulären Mikrotubuli-Apparates, was mit einer Entzündungshemmung verbunden ist. Trotz hoher Toxizität werden isoliertes Colchicin und Herbstzeitlosen-Extrakte zur Behandlung von Gicht eingesetzt. Weitere Anwendungsgebiete werden derzeit erforscht.

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