Observation of T Cell Surface Antigens in the Clinical Course of Adult T-Cell Leukemia: Case Report of a Spontaneous Remission

1995 ◽  
Vol 93 (1) ◽  
pp. 40-45 ◽  
Author(s):  
Muneou Suzuki ◽  
Hisamitsu Uno ◽  
Akihiko Kiyomizu ◽  
Youko Kubuki ◽  
Kiyoshi Yamashita ◽  
...  
Keyword(s):  
Case Report ◽  
T Cell ◽  
Cell Surface ◽  
Clinical Course ◽  
Spontaneous Remission ◽  
Surface Antigens ◽  
T Cell Leukemia ◽  
Cell Leukemia ◽  
Cell Surface Antigens ◽  
Adult T Cell Leukemia

scholarly journals Changes of adult T cell leukemia cell surface antigens at relapse or at exacerbation phase after chemotherapy defined by use of monoclonal antibodies

Blood ◽  
1984 ◽  
Vol 64 (2) ◽  
pp. 440-444
Author(s):  
Y Yamada ◽  
S Kamihira ◽  
T Amagasaki ◽  
K Kinoshita ◽  
M Kusano ◽  
...  
Keyword(s):  
Monoclonal Antibodies ◽  
T Cell ◽  
Cell Surface ◽  
Morphological Change ◽  
Surface Antigens ◽  
Leukemic Cells ◽  
Cell Leukemia ◽  
Cell Surface Antigens ◽  
Adult T Cell Leukemia ◽  
Immature Cells

Surface phenotypes of leukemic cells from six patients with adult T cell leukemia (ATL) were analyzed by the use of monoclonal antibodies, both at the time of initial diagnosis and at either relapse or exacerbation phase after chemotherapy. Changes of cell surface antigens were observed in four of the six cases. The majority of the leukemic cells of these patients were reactive with anti-Leu-1 and anti-Leu-3a, but unreactive with anti-Leu-2a and MAS 036c monoclonal antibodies at the time of initial diagnosis, indicating that ATL cells are of peripheral inducer/helper T cell origin. In three cases, the Leu-1 antigen disappeared at relapse or at exacerbation phase, and in one of these cases, a small percentage of ATL cells became reactive with MAS 036c, which identifies cortical thymocyte antigen. ATL cells of one other case did not have Leu-1 antigen from the start, but gained Leu-2a antigen at exacerbation phase and became double-labeled cells (Leu-2a+, 3a+), which is known to be a feature of thymocytes. Thus, it appeared that ATL cells sometimes change their surface phenotype to that of an earlier stage of T cell differentiation at relapse or at exacerbation phase. Chronic myelocytic leukemia (CML) cells also usually change to immature cells at blastic crisis involving morphological change. However, this morphological change was not so prominent in the ATL cases studied, except one, in which typical ATL cells with nuclear indentation changed to large immature cells with basophilic cytoplasm at relapse.

scholarly journals Changes of adult T cell leukemia cell surface antigens at relapse or at exacerbation phase after chemotherapy defined by use of monoclonal antibodies

Blood ◽  
1984 ◽  
Vol 64 (2) ◽  
pp. 440-444 ◽  
Author(s):  
Y Yamada ◽  
S Kamihira ◽  
T Amagasaki ◽  
K Kinoshita ◽  
M Kusano ◽  
...  
Keyword(s):  
Monoclonal Antibodies ◽  
T Cell ◽  
Cell Surface ◽  
Morphological Change ◽  
Surface Antigens ◽  
Leukemic Cells ◽  
Cell Leukemia ◽  
Cell Surface Antigens ◽  
Adult T Cell Leukemia ◽  
Immature Cells

Abstract Surface phenotypes of leukemic cells from six patients with adult T cell leukemia (ATL) were analyzed by the use of monoclonal antibodies, both at the time of initial diagnosis and at either relapse or exacerbation phase after chemotherapy. Changes of cell surface antigens were observed in four of the six cases. The majority of the leukemic cells of these patients were reactive with anti-Leu-1 and anti-Leu-3a, but unreactive with anti-Leu-2a and MAS 036c monoclonal antibodies at the time of initial diagnosis, indicating that ATL cells are of peripheral inducer/helper T cell origin. In three cases, the Leu-1 antigen disappeared at relapse or at exacerbation phase, and in one of these cases, a small percentage of ATL cells became reactive with MAS 036c, which identifies cortical thymocyte antigen. ATL cells of one other case did not have Leu-1 antigen from the start, but gained Leu-2a antigen at exacerbation phase and became double-labeled cells (Leu-2a+, 3a+), which is known to be a feature of thymocytes. Thus, it appeared that ATL cells sometimes change their surface phenotype to that of an earlier stage of T cell differentiation at relapse or at exacerbation phase. Chronic myelocytic leukemia (CML) cells also usually change to immature cells at blastic crisis involving morphological change. However, this morphological change was not so prominent in the ATL cases studied, except one, in which typical ATL cells with nuclear indentation changed to large immature cells with basophilic cytoplasm at relapse.

Comparative genomic hybridization analysis in adult T-cell leukemia/lymphoma: correlation with clinical course

Blood ◽  
2001 ◽  
Vol 97 (12) ◽  
pp. 3875-3881 ◽  
Author(s):  
Kunihiro Tsukasaki ◽  
Johannes Krebs ◽  
Kazuhiro Nagai ◽  
Masao Tomonaga ◽  
H. Phillip Koeffler ◽  
...  
Keyword(s):  
T Cell ◽  
Comparative Genomic Hybridization ◽  
Clinical Course ◽  
Comparative Genomic ◽  
T Cell Leukemia ◽  
Cell Leukemia ◽  
Genomic Hybridization ◽  
Adult T Cell Leukemia ◽  
Paired Samples ◽  
Sequential Samples

Sixty-four patients with adult T-cell leukemia/lymphoma (ATL; 18 patients with indolent subtype and 46 with aggressive subtype) associated with human T-lymphotropic virus type 1 (HTLV-1) were analyzed using comparative genomic hybridization (CGH). The most frequent observations were gains at chromosomes 14q, 7q, and 3p and losses at chromosomes 6q and 13q. Chromosome imbalances, losses, and gains were more frequently observed in aggressive ATL than in indolent ATL, with significant differences between the 2 ATL subtypes at gains of 1q and 4q. An increased number of chromosomal imbalances was associated with a significantly shorter survival in all patients. A high number of chromosomal losses was associated with a poor prognosis in indolent ATL, whereas the presence of 7q+ was marginally associated with a good prognosis in aggressive ATL. Paired samples (ie, samples obtained at different sites from 4 patients) and sequential samples from 13 patients (from 6 during both chronic disease and acute crisis and from 7 during both acute onset and relapse) were examined by CGH and Southern blotting for HTLV-1. All but 2 paired samples showed differences on CGH assessment. Two chronic/crisis samples showed distinct results regarding both CGH and HTLV-1 integration sites, indicating clonal changes in ATL at crisis. In 11 patients, the finding of identical HTLV-1 sites and clonally related CGH results suggested a common origin of sequential samples. In contrast to chronic/crisis samples, CGH results with all acute/relapse sample pairs showed the presence of clonally related but not evolutional subclones at relapse, thereby suggesting marked chromosomal instability. In summary, clonal diversity is common during progression of ATL, and CGH alterations are associated with clinical course.

Scabies superimposed on skin lesions of adult T-cell leukemia/lymphoma: case report and literature review

2008 ◽  
Vol 47 (11) ◽  
pp. 1168-1171 ◽  
Author(s):  
Rieko Kabashima ◽  
Kenji Kabashima ◽  
Ryosuke Hino ◽  
Takatoshi Shimauchi ◽  
Yoshiki Tokura
Keyword(s):  
Case Report ◽  
T Cell ◽  
Literature Review ◽  
Skin Lesions ◽  
T Cell Leukemia ◽  
Cell Leukemia ◽  
Adult T Cell Leukemia

scholarly journals Adult T-cell leukemia-lymphoma manifesting as lethal midline granuloma; A case report.

1989 ◽  
Vol 82 (5) ◽  
pp. 657-664 ◽  
Author(s):  
Naohiro Takeda ◽  
Noriko Takeda ◽  
Hiroshi Ogasawara ◽  
Takeo Kumoi
Keyword(s):  
Case Report ◽  
T Cell ◽  
T Cell Leukemia ◽  
Cell Leukemia ◽  
Adult T Cell Leukemia ◽  
Lethal Midline Granuloma ◽  
Midline Granuloma

scholarly journals Case of adult T-cell leukemia resulting in spontaneous remission and pancytopenia

2000 ◽  
Vol 65 (4) ◽  
pp. 325-326 ◽  
Author(s):  
Kazuhiko Muraki ◽  
Kenji Shinohara ◽  
Toru Takahashi ◽  
Itsuro Ota ◽  
Ryohei Nawata
Keyword(s):  
T Cell ◽  
Spontaneous Remission ◽  
T Cell Leukemia ◽  
Cell Leukemia ◽  
Adult T Cell Leukemia

Adult T-cell Leukemia/Lymphoma: First case report from Qatar

2008 ◽  
Vol 2008 (1) ◽  
pp. 19 ◽  
Author(s):  
K. I. Rasul ◽  
M. T. Abbas ◽  
A. S. Binali ◽  
N. Murad
Keyword(s):  
Case Report ◽  
T Cell ◽  
T Cell Leukemia ◽  
Cell Leukemia ◽  
Adult T Cell Leukemia ◽  
First Case

Spontaneous Remission in Acute Type Adult T-Cell Leukemia/Lymphoma

2000 ◽  
Vol 39 (1-2) ◽  
pp. 217-222 ◽  
Author(s):  
Yayoi Takezako ◽  
Yoshinobu Kanda ◽  
Chiaki Arai ◽  
Naoki Takezako ◽  
Yuko Shirai ◽  
...  
Keyword(s):  
T Cell ◽  
Spontaneous Remission ◽  
Acute Type ◽  
T Cell Leukemia ◽  
Cell Leukemia ◽  
Adult T Cell Leukemia
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