Vitamin E Supplementation Reduces Oxidative Stress in Beta Thalassaemia Intermedia

2008 ◽  
Vol 120 (4) ◽  
pp. 225-231 ◽  
Author(s):  
W.P. Pfeifer ◽  
G.R. Degasperi ◽  
M.T. Almeida ◽  
A.E. Vercesi ◽  
F.F. Costa ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Vitamin E ◽  
Beta Thalassaemia ◽  
Thalassaemia Intermedia ◽  
Vitamin E Supplementation

scholarly journals Global gene expression reveals an increase of HMGB1 and APEX1 proteins and their involvement in oxidative stress, apoptosis and inflammation pathways among beta‐thalassaemia intermedia and major phenotypes

2019 ◽  
Vol 186 (4) ◽  
pp. 608-619 ◽  
Author(s):  
João Pedro Maia de Oliveira da Silva ◽  
Ana Flávia Brugnerotto ◽  
Karen S. Romanello ◽  
Karina K. L. Teixeira ◽  
Carolina Lanaro ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Gene Expression ◽  
Global Gene Expression ◽  
Beta Thalassaemia ◽  
Apoptosis And Inflammation ◽  
Thalassaemia Intermedia

Vitamin E Supplementation Increases LDL Resistance to ex vivo Oxidation in Hemodialysis Patients

2003 ◽  
Vol 73 (4) ◽  
pp. 290-296 ◽  
Author(s):  
Badiou ◽  
Cristol ◽  
Morena ◽  
Bosc ◽  
Carbonneau ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Vitamin E ◽  
High Performance ◽  
Ex Vivo ◽  
Density Lipoprotein ◽  
Thiobarbituric Acid ◽  
Hemodialysis Patients ◽  
Ldl Oxidation ◽  
Oral Vitamin ◽  
Vitamin E Supplementation

Background: Oxidative stress and alterations in lipid metabolism observed in hemodialysis patients potentiate the low-density lipoprotein (LDL) oxidability, recognized as a key event during early atherogenesis. Objective: To explore the effects of an oral vitamin E supplementation on oxidative stress markers and LDL oxidability in hemodialysis patients. Methods: Fourteen hemodialysis patients and six healthy volunteers were given oral vitamin E (500 mg/day) for six months. Oxidative stress was assessed using: plasma and lipoprotein vitamin E levels [high-performance liquid chromatography (HPLC) procedure]; thiobarbituric acid reactive substances (TBARS, Yaggi method); and copper-induced LDL oxidation. All parameters were evaluated before initiation of vitamin E supplementation, and at three and six months thereafter. Results: At baseline, a significantly higher TBARS concentration and a higher LDL oxidability were observed in hemodialysis patients when compared to controls. After six months of vitamin E supplementation, TBARS and LDL oxidability were normalized in hemodialysis patients. Conclusion: Our data confirm that hemodialysis patients are exposed to oxidative stress and increased susceptibility to ex vivo LDL oxidation. Since oral vitamin E supplementation prevents oxidative stress and significantly increases LDL resistance to ex vivo oxidation, supplementation by natural antioxidants such as vitamin E may be beneficial in hemodialysis patients.

scholarly journals The effects of vitamin E supplementation on autoimmune-prone New Zealand black × New Zealand white F1 mice fed an oxidised oil diet

2005 ◽  
Vol 93 (5) ◽  
pp. 655-662 ◽  
Author(s):  
Chia-Chien Hsieh ◽  
Bi-Fong Lin
Keyword(s):  
Oxidative Stress ◽  
New Zealand ◽  
Vitamin E ◽  
Autoimmune Disease ◽  
Mhc Class Ii ◽  
Tocopheryl Acetate ◽  
Thiobarbituric Acid Reactive Substance ◽  
Igg Antibody ◽  
Double Stranded Dna ◽  
Vitamin E Supplementation

The purpose of the present study was to investigate the effect of vitamin E supplementation on autoimmune disease in New Zealand black×New Zealand white F1(NZB/W F1) female mice fed an oxidised oil diet. First, 5-month-old mice were fed an AIN-76 diet containing either 150 g fresh soyabean oil/kg (15S), 50 g fresh soyabean oil/kg + 100 g oxidised frying oil/kg (5S10F) or 5S10F supplemented with all-rac-α-tocopheryl acetate at 275 mg/kg diet level (5S10F5E) or 550 mg/kg (5S10F10E), respectively, in experiment 1. The results showed that mice fed the 5S10F10E diet had a lower anti-double-stranded DNA IgG antibody level and a longer lifespan than those fed the 15S and 5S10F diets. Therefore, the 5S10F and 5S10F10E treatments were repeated in experiment 2 for further analysis. The results showed that vitamin E supplementation in the oxidised oil significantly decreased thiobarbituric acid-reactive substance values in the kidney and spleen of NZB/W F1mice. Interferon-γ and IL-6 production by mitogen-stimulated splenocytes decreased in mice fed the 5S10F10E diet, whereas the secretion of IL-2 and IL-10 was not affected. The percentage of T-cells was significantly higher and that of MHC class II-bearing cells was lower in the spleens of the 5S10F10E group. The 5S10F10E group had a significantly higher linoleic acid (18: 2n-6) composition than the 5S10F diet group. Therefore, vitamin E supplementation in oxidised oil might decrease oxidative stress, anti-double-stranded DNA IgG antibody, regulate cytokines and lymphocyte subsets, and subsequently alleviate the severity of autoimmune disease such as systemic lupus erythematosus under oxidative stress.

Evaluation of oxidative stress before and after control of glycemia and after vitamin E supplementation in diabetic patients

Metabolism ◽  
2000 ◽  
Vol 49 (2) ◽  
pp. 160-162 ◽  
Author(s):  
Anjali Sharma ◽  
Simmi Kharb ◽  
S.N. Chugh ◽  
Rajesh Kakkar ◽  
G.P. Singh
Keyword(s):  
Oxidative Stress ◽  
Vitamin E ◽  
Diabetic Patients ◽  
Before And After ◽  
Vitamin E Supplementation
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