Intravenous Omeprazole: Effect on 24-Hour Intragastric pH in Duodenal Ulcer Patients

Digestion ◽  
1986 ◽  
Vol 34 (2) ◽  
pp. 78-86 ◽  
Author(s):  
Tore Lind ◽  
Marianne Moore ◽  
Lars Olbe
Keyword(s):  
Duodenal Ulcer ◽  
Intragastric Ph

scholarly journals Maintenance of intragastric pH > 4 with famotidine in duodenal ulcer patients: factors influencing drug requirements.

Gut ◽  
1994 ◽  
Vol 35 (6) ◽  
pp. 750-754 ◽  
Author(s):  
J C Delchier ◽  
F Roudot-Thoraval ◽  
L Stanescu ◽  
M C Deharvengt ◽  
L Elouaer Blanc
Keyword(s):  
Duodenal Ulcer ◽  
Intragastric Ph ◽  
Factors Influencing

Evaluation of antisecretory activity of misoprostol in duodenal ulcer patients using long-term intragastric pH monitoring

1988 ◽  
Vol 33 (3) ◽  
pp. 293-297 ◽  
Author(s):  
V. Savarino ◽  
P. Scalabrini ◽  
G. S. Mela ◽  
E. Di Timoteo ◽  
G. Percario ◽  
...  
Keyword(s):  
Duodenal Ulcer ◽  
Ph Monitoring ◽  
Intragastric Ph ◽  
Antisecretory Activity

scholarly journals Pharmacokinetics and Pharmacodynamics during Treatment with the Omeprazole 20 mg Enteric-Coated Tablet and 20 mg Capsule in Asymptomatic Duodenal Ulcer Patients

1997 ◽  
Vol 11 (8) ◽  
pp. 657-660 ◽  
Author(s):  
ABR Thomson ◽  
P Kirdeikis ◽  
R Lastiwka ◽  
K Rohss ◽  
P Sinclair ◽  
...  
Keyword(s):  
Duodenal Ulcer ◽  
Plasma Concentration ◽  
Plasma Concentrations ◽  
Maximum Plasma ◽  
Intragastric Ph ◽  
Time Curve ◽  
Enteric Coated Tablet ◽  
Coated Tablet ◽  
Enteric Coated ◽  
Repeated Dosing

This study compared the 24 h intragastric pH profile and bioavailability at repeated dosing conditions of the omeprazole 20 mg enteric-coated tablet versus the 20 mg capsule. Forty duodenal ulcer patients in asymptomatic remission completed this randomized open two-way crossover study. Omeprazole 20 mg tablets or capsules were administered for seven days in each period. A 24 h pH recording was performed before the start of treatment and on day 7 of each treatment period. Plasma concentrations of omeprazole were determined 24 h after the dose. The treatment periods were separated by two to four weeks. The difference in percentage of time with pH of at least 3 was less than 16% in favour of the tablet (not significant). The estimated mean area under the plasma concentration-time curve as well as the maximum plasma concentration (Cmax) for omeprazole were 18% and 41% higher, respectively, for the tablet versus the capsule, with the latter percentage being statistically significant. The time to reach Cmax(tmax) with the tablet was, on average, about 0.5 h longer than to reach the tmaxof the capsule. This study indicates that the enteric-coated tablet formulation of omeprazole is biodynamically equivalent to the capsule regarding their effects on intragastric pH during repeated dosing.

Continuous 24-Hour Intragastric pH Monitoring in the Evaluation of the Effect of a Nightly Dose of Famotidine, Ranitidine and Placebo on Gastric Acidity of Patients with Duodenal Ulcer

Digestion ◽  
1987 ◽  
Vol 37 (2) ◽  
pp. 103-109 ◽  
Author(s):  
Vincenzo Savarino ◽  
Giuseppe Sandro Mela ◽  
Patrizia Scalabrini ◽  
Ezio Di Timoteo ◽  
Maria Rita Magnolia ◽  
...  
Keyword(s):  
Duodenal Ulcer ◽  
Gastric Acidity ◽  
Ph Monitoring ◽  
Intragastric Ph
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