Evaluation of antisecretory activity of misoprostol in duodenal ulcer patients using long-term intragastric pH monitoring

1988 ◽  
Vol 33 (3) ◽  
pp. 293-297 ◽  
Author(s):  
V. Savarino ◽  
P. Scalabrini ◽  
G. S. Mela ◽  
E. Di Timoteo ◽  
G. Percario ◽  
...  
Keyword(s):  
Duodenal Ulcer ◽  
Ph Monitoring ◽  
Intragastric Ph ◽  
Antisecretory Activity

Experience with Long-Term Intragastric pH Monitoring as a Test after Proximal Gastric Vagotomy

1989 ◽  
Vol 6 (1) ◽  
pp. 33-38 ◽  
Author(s):  
Arnulf H. Hölscher ◽  
Elfriede Bollschweiler ◽  
Ludwig Seebauer ◽  
Andrew T.R. Alcock ◽  
Rüdiger Siewert
Keyword(s):  
Ph Monitoring ◽  
Intragastric Ph ◽  
Proximal Gastric Vagotomy

Continuous 24-Hour Intragastric pH Monitoring in the Evaluation of the Effect of a Nightly Dose of Famotidine, Ranitidine and Placebo on Gastric Acidity of Patients with Duodenal Ulcer

Digestion ◽  
1987 ◽  
Vol 37 (2) ◽  
pp. 103-109 ◽  
Author(s):  
Vincenzo Savarino ◽  
Giuseppe Sandro Mela ◽  
Patrizia Scalabrini ◽  
Ezio Di Timoteo ◽  
Maria Rita Magnolia ◽  
...  
Keyword(s):  
Duodenal Ulcer ◽  
Gastric Acidity ◽  
Ph Monitoring ◽  
Intragastric Ph

Long-term cimetidine in duodenal ulcer disease

1979 ◽  
Vol 24 (6) ◽  
pp. 465-467 ◽  
Author(s):  
J. Hansky ◽  
M. G. Korman
Keyword(s):  
Duodenal Ulcer ◽  
Duodenal Ulcer Disease ◽  
Ulcer Disease

Relapse rate of duodenal ulcer after cessation of long-term cimetidine treatment

1980 ◽  
Vol 25 (2) ◽  
pp. 88-91 ◽  
Author(s):  
Melvyn G. Korman ◽  
David J. Hetzel ◽  
Jack Hansky ◽  
David J. C. Shearman ◽  
Gregory Don
Keyword(s):  
Duodenal Ulcer ◽  
Relapse Rate ◽  
Cimetidine Treatment

The Effect of a Single Oral Morning Dose of Nizatidine and Ranitidine on Intragastric pH under Basal Conditions and after Pentagastrin Stimulation

1992 ◽  
Vol 20 (6) ◽  
pp. 454-460 ◽  
Author(s):  
M Lazzaroni ◽  
O Sangaletti ◽  
G Bianchi Porro
Keyword(s):  
Drug Administration ◽  
Inhibitory Action ◽  
Glass Electrode ◽  
Intragastric Ph ◽  
Morning Dose ◽  
Experimental Conditions ◽  
Duodenal Ulcers ◽  
Ph Values ◽  
Antisecretory Activity ◽  
Single Blind

A comparison was made of the antisecretory activity of orally administered nizatidine and ranitidine by measuring intragastric pH under basal conditions and during and after pentagastrin stimulation. Intragastric pH values were measured with a bipolar glass electrode in 10 patients with healed duodenal ulcers treated with nizatidine or ranitidine according to a randomized single-blind design. The antisecretory activity of the two drugs was similar during the 4 h of monitoring following drug administration. Nizatidine, however, showed a more rapid inhibitory action than ranitidine, producing a significantly greater increase in pH with respect to basal values during pentagastrin infusion. In the period following infusion the pH values observed with ranitidine were higher than with nizatidine, but not significantly so. Under these experimental conditions, therefore, the antisecretory activity of nizatidine was shown to be more rapid than that of ranitidine and equally effective.

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