Ganglionic Eminence Revisited: A Review Embracing Observations from Our Laboratory

2008 ◽  
Vol 5 (4) ◽  
pp. 121-126
Author(s):  
Maria S.M. Wai ◽  
Lihong Zhang ◽  
D.T. Yew
Keyword(s):  
Ganglionic Eminence

Ganglionic eminence cavitations. These are not choroid plexus cysts!

2021 ◽  
Author(s):  
M. Brusilov ◽  
G. Malinger ◽  
U. Erlik ◽  
K. K. Haratz
Keyword(s):  
Choroid Plexus ◽  
Ganglionic Eminence

Regionalization within the mammalian telencephalon is mediated by changes in responsiveness to Sonic Hedgehog

Development ◽  
1998 ◽  
Vol 125 (24) ◽  
pp. 5079-5089 ◽  
Author(s):  
J.D. Kohtz ◽  
D.P. Baker ◽  
G. Corte ◽  
G. Fishell
Keyword(s):  
Basal Ganglia ◽  
Globus Pallidus ◽  
Sonic Hedgehog ◽  
Adult Brain ◽  
Ganglionic Eminence ◽  
Lateral Ganglionic Eminence ◽  
Expression Characteristic ◽  
Sonic Hedgehog Gene ◽  
Embryonic Structure ◽  
Sequential Induction

The cortex and basal ganglia are the major structures of the adult brain derived from the embryonic telencephalon. Two morphologically distinct regions of the basal ganglia are evident within the mature ventral telencephalon, the globus pallidus medially, and the striatum, which is positioned between the globus pallidus and the cortex. Deletion of the Sonic Hedgehog gene in mice indicates that this secreted signaling molecule is vital for the generation of both these ventral telencephalic regions. Previous experiments showed that Sonic Hedgehog induces differentiation of ventral neurons characteristic of the medial ganglionic eminence, the embryonic structure which gives rise to the globus pallidus. In this paper, we show that later in development, Sonic Hedgehog induces ventral neurons with patterns of gene expression characteristic of the lateral ganglionic eminence. This is the embryonic structure from which the striatum is derived. These results suggest that temporally regulated changes in Sonic Hedgehog responsiveness are integral in the sequential induction of basal telencephalic structures.

scholarly journals The Medial Ganglionic Eminence Gives Rise to a Population of Early Neurons in the Developing Cerebral Cortex

1999 ◽  
Vol 19 (18) ◽  
pp. 7881-7888 ◽  
Author(s):  
Alexandros A. Lavdas ◽  
Maria Grigoriou ◽  
Vassilis Pachnis ◽  
John G. Parnavelas
Keyword(s):  
Cerebral Cortex ◽  
Medial Ganglionic Eminence ◽  
Ganglionic Eminence

scholarly journals Generation and Fusion of Human Cortical and Medial Ganglionic Eminence Brain Organoids

2018 ◽  
Vol 47 (1) ◽  
pp. e61 ◽  
Author(s):  
Yangfei Xiang ◽  
Tanaka Yoshiaki ◽  
Benjamin Patterson ◽  
Bilal Cakir ◽  
Kun-Yong Kim ◽  
...  
Keyword(s):  
Medial Ganglionic Eminence ◽  
Ganglionic Eminence

Expression of MAP1a and MAP1b in the ganglionic eminence and the internal capsule of the human fetal brain

2000 ◽  
Vol 38 (4) ◽  
pp. 397-405 ◽  
Author(s):  
Norbert Ulfig ◽  
Christian Feldhaus ◽  
Matthias Setzer ◽  
Jürgen Bohl
Keyword(s):  
Fetal Brain ◽  
Internal Capsule ◽  
Ganglionic Eminence ◽  
Human Fetal Brain

Young neurons from medial ganglionic eminence disperse in adult and embryonic brain

10.1038/8131 ◽  
1999 ◽  
Vol 2 (5) ◽  
pp. 461-466 ◽  
Author(s):  
Hynek Wichterle ◽  
Jose Manuel Garcia-Verdugo ◽  
Daniel G. Herrera ◽  
Arturo Alvarez-Buylla
Keyword(s):  
Embryonic Brain ◽  
Medial Ganglionic Eminence ◽  
Ganglionic Eminence

scholarly journals Interneuron origins in the embryonic porcine medial ganglionic eminence

2020 ◽  
Author(s):  
Mariana L. Casalia ◽  
Tina Li ◽  
Harrison Ramsay ◽  
Pablo J. Ross ◽  
Mercedes F. Paredes ◽  
...  
Keyword(s):  
Expression Patterns ◽  
Normal Brain ◽  
Female Rat ◽  
Medial Ganglionic Eminence ◽  
Ganglionic Eminence ◽  
Embryonic Mouse ◽  
Migratory Capacity ◽  
Normal Brain Function ◽  
Transcription Factor Expression

Interneurons contribute to the complexity of neural circuits and maintenance of normal brain function. Rodent interneurons originate in embryonic ganglionic eminences, but developmental origins in other species are less understood. Here, we show that transcription factor expression patterns in porcine embryonic subpallium are similar to rodents, delineating a distinct medial ganglionic eminence (MGE) progenitor domain. On the basis of Nkx2.1, Lhx6 and Dlx2 expression, in vitro differentiation into neurons expressing GABA and robust migratory capacity in explant assays, we propose that cortical and hippocampal interneurons originate from a porcine MGE region. Following xenotransplantation into adult male and female rat hippocampus, we further demonstrate that porcine MGE progenitors, like those from rodents, migrate and differentiate into morphologically distinct interneurons expressing GABA. Our findings reveal that basic rules for interneuron development are conserved across species, and that porcine embryonic MGE progenitors could serve as a valuable source for interneuron-based xenotransplantation therapies.Significance StatementHere we demonstrate that porcine MGE, like rodents, exhibit a distinct transcriptional and pallial interneuron-specific antibody profile, in vitro migratory capacity and are amenable to xenotransplantation. This is the first comprehensive examination of embryonic pallial interneuron origins in the pig, and because a rich neurodevelopmental literature on embryonic mouse MGE exists (with some additional characterizations in other species like monkey and human) our work allows direct neurodevelopmental comparisons with this literature.

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