scholarly journals Generation and Fusion of Human Cortical and Medial Ganglionic Eminence Brain Organoids

2018 ◽  
Vol 47 (1) ◽  
pp. e61 ◽  
Author(s):  
Yangfei Xiang ◽  
Tanaka Yoshiaki ◽  
Benjamin Patterson ◽  
Bilal Cakir ◽  
Kun-Yong Kim ◽  
...  
Keyword(s):  
Medial Ganglionic Eminence ◽  
Ganglionic Eminence

scholarly journals The Medial Ganglionic Eminence Gives Rise to a Population of Early Neurons in the Developing Cerebral Cortex

1999 ◽  
Vol 19 (18) ◽  
pp. 7881-7888 ◽  
Author(s):  
Alexandros A. Lavdas ◽  
Maria Grigoriou ◽  
Vassilis Pachnis ◽  
John G. Parnavelas
Keyword(s):  
Cerebral Cortex ◽  
Medial Ganglionic Eminence ◽  
Ganglionic Eminence

Young neurons from medial ganglionic eminence disperse in adult and embryonic brain

10.1038/8131 ◽  
1999 ◽  
Vol 2 (5) ◽  
pp. 461-466 ◽  
Author(s):  
Hynek Wichterle ◽  
Jose Manuel Garcia-Verdugo ◽  
Daniel G. Herrera ◽  
Arturo Alvarez-Buylla
Keyword(s):  
Embryonic Brain ◽  
Medial Ganglionic Eminence ◽  
Ganglionic Eminence

scholarly journals Interneuron origins in the embryonic porcine medial ganglionic eminence

2020 ◽  
Author(s):  
Mariana L. Casalia ◽  
Tina Li ◽  
Harrison Ramsay ◽  
Pablo J. Ross ◽  
Mercedes F. Paredes ◽  
...  
Keyword(s):  
Expression Patterns ◽  
Normal Brain ◽  
Female Rat ◽  
Medial Ganglionic Eminence ◽  
Ganglionic Eminence ◽  
Embryonic Mouse ◽  
Migratory Capacity ◽  
Normal Brain Function ◽  
Transcription Factor Expression

Interneurons contribute to the complexity of neural circuits and maintenance of normal brain function. Rodent interneurons originate in embryonic ganglionic eminences, but developmental origins in other species are less understood. Here, we show that transcription factor expression patterns in porcine embryonic subpallium are similar to rodents, delineating a distinct medial ganglionic eminence (MGE) progenitor domain. On the basis of Nkx2.1, Lhx6 and Dlx2 expression, in vitro differentiation into neurons expressing GABA and robust migratory capacity in explant assays, we propose that cortical and hippocampal interneurons originate from a porcine MGE region. Following xenotransplantation into adult male and female rat hippocampus, we further demonstrate that porcine MGE progenitors, like those from rodents, migrate and differentiate into morphologically distinct interneurons expressing GABA. Our findings reveal that basic rules for interneuron development are conserved across species, and that porcine embryonic MGE progenitors could serve as a valuable source for interneuron-based xenotransplantation therapies.Significance StatementHere we demonstrate that porcine MGE, like rodents, exhibit a distinct transcriptional and pallial interneuron-specific antibody profile, in vitro migratory capacity and are amenable to xenotransplantation. This is the first comprehensive examination of embryonic pallial interneuron origins in the pig, and because a rich neurodevelopmental literature on embryonic mouse MGE exists (with some additional characterizations in other species like monkey and human) our work allows direct neurodevelopmental comparisons with this literature.

scholarly journals Ambient GABA Promotes Cortical Entry of Tangentially Migrating Cells Derived from the Medial Ganglionic Eminence

2005 ◽  
Vol 16 (10) ◽  
pp. 1377-1388 ◽  
Author(s):  
Verginia C. Cuzon ◽  
Pamela W. Yeh ◽  
Qing Cheng ◽  
Hermes H. Yeh
Keyword(s):  
Medial Ganglionic Eminence ◽  
Ganglionic Eminence ◽  
Ambient Gaba ◽  
Migrating Cells

Addition of Lateral Ganglionic Eminence to Rat Mesencephalic Grafts Affects Fiber Outgrowth but Does not Enhance Function

1997 ◽  
Vol 6 (3) ◽  
pp. 277-286 ◽  
Author(s):  
Mia Emgard-Mattson ◽  
Jenny Karlsson ◽  
Naoyuki Nakao ◽  
Patrik Brundin
Keyword(s):  
Dopaminergic Neurons ◽  
Recovery Of Function ◽  
Rotational Behavior ◽  
Specific Marker ◽  
Medial Ganglionic Eminence ◽  
Ganglionic Eminence ◽  
Drug Induced ◽  
Lateral Ganglionic Eminence ◽  
Axonal Fiber ◽  
6 Hydroxydopamine

Addition of embryonic striatal tissue, usually as a combination of the lateral and medial ganglionic eminences, to intrastriatal mesencephalic grafts has previously been reported to enhance recovery of drug-induced rotational behavior in the host and to modify axonal fiber outgrowth from the grafted dopaminergic neurons. This study investigated the effects of adding (cografting) either lateral or medial ganglionic eminence tissue to embryonic mesencephalic grafts implanted intrastriatally, in rats with unilateral 6-hydroxydopamine lesions. The cografts did not exhibit increased survival or cell size of dopaminergic neurons when compared to transplants of mesencephalic tissue alone. Neither did recipients of cografts exhibit any enhancement of graft-induced recovery of function, when tested for drug-induced rotational behavior or forelimb function in the staircase test. However, cografts containing lateral ganglionic eminence displayed patches of dense tyrosine hydroxylase-immunoreactive fibers within the graft tissue. These patches largely coincided with patches in adjacent stained sections, which were rich in immunostaining for the striatal-specific marker dopamine- and cyclic AMP-regulated phosphoprotein-32 (DARPP-32). Such patches were not present in rats receiving cografts containing medial ganglionic eminence or mesencephalic tissue alone. Thus, it seems that the grafted dopaminergic neurons preferentially grow into the areas of the transplants containing lateral ganglionic eminence tissue. In summary, the results suggest that embryonic lateral ganglionic eminence exerts trophic effects on the outgrowth of dopaminergic axons, but does not enhance the behavioral effects of grafted dopaminergic neurons.

scholarly journals Nf1deletion results in depletion of theLhx6transcription factor and a specific loss of parvalbumin+cortical interneurons

2020 ◽  
Vol 117 (11) ◽  
pp. 6189-6195 ◽  
Author(s):  
Kartik Angara ◽  
Emily Ling-Lin Pai ◽  
Stephanie M. Bilinovich ◽  
April M. Stafford ◽  
Julie T. Nguyen ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Mek Inhibitor ◽  
Gabaergic Interneurons ◽  
Medial Ganglionic Eminence ◽  
Ganglionic Eminence ◽  
Specific Loss ◽  
Developmental Milestone ◽  
Cortical Interneurons ◽  
Dose Dependent Decrease ◽  
Dose Dependent

Neurofibromatosis 1 (NF1) is caused by mutations in theNF1gene, which encodes the protein, neurofibromin, an inhibitor of Ras activity. Cortical GABAergic interneurons (CINs) are implicated in NF1 pathology, but the cellular and molecular changes to CINs are unknown. We deleted mouseNf1from the medial ganglionic eminence, which gives rise to both oligodendrocytes and CINs that express somatostatin and parvalbumin.Nf1loss led to a persistence of immature oligodendrocytes that prevented later-generated oligodendrocytes from occupying the cortex. Moreover, molecular and cellular properties of parvalbumin (PV)-positive CINs were altered by the loss ofNf1, without changes in somatostatin (SST)-positive CINs. We discovered that loss ofNf1results in a dose-dependent decrease inLhx6expression, the transcription factor necessary to establish SST+and PV+CINs, which was rescued by the MEK inhibitor SL327, revealing a mechanism whereby a neurofibromin/Ras/MEK pathway regulates a critical CIN developmental milestone.

Transient maternal hypothyroxinemia at onset of corticogenesis alters tangential migration of medial ganglionic eminence-derived neurons

2005 ◽  
Vol 22 (3) ◽  
pp. 541-551 ◽  
Author(s):  
Estela Cuevas ◽  
Eva Ausó ◽  
Martin Telefont ◽  
Gabriella Morreale de Escobar ◽  
Constantino Sotelo ◽  
...  
Keyword(s):  
Medial Ganglionic Eminence ◽  
Ganglionic Eminence ◽  
Tangential Migration

scholarly journals Topographical transcriptome mapping of the mouse medial ganglionic eminence by spatially resolved RNA-seq

2014 ◽  
Vol 15 (10) ◽  
Author(s):  
Sabrina Zechel ◽  
Pawel Zajac ◽  
Peter Lönnerberg ◽  
Carlos F Ibáñez ◽  
Sten Linnarsson
Keyword(s):  
Rna Seq ◽  
Medial Ganglionic Eminence ◽  
Ganglionic Eminence ◽  
Spatially Resolved
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