Urinary Trehalase Activity Is a Useful Marker of Renal Proximal Tubular Damage in Newborn Infants

Nephron ◽  
1995 ◽  
Vol 70 (4) ◽  
pp. 443-448 ◽  
Author(s):  
Misa Sasai-Takedatsu ◽  
Takatsugu Kojima ◽  
Shigeru Taketani ◽  
Atsushi Ono ◽  
Naoyuki Kitamura ◽  
...  
Keyword(s):  
Newborn Infants ◽  
Tubular Damage ◽  
Trehalase Activity ◽  
Proximal Tubular ◽  
Proximal Tubular Damage ◽  
Renal Proximal Tubular

New insights into the mechanisms involved in renal proximal tubular damage induced in vitro by ochratoxin A

2004 ◽  
Vol 18 (1) ◽  
pp. 43-49 ◽  
Author(s):  
Alessandra Gennari ◽  
Patricia Pazos ◽  
Monica Boveri ◽  
Robert Callaghan ◽  
Juan Casado ◽  
...  
Keyword(s):  
Ochratoxin A ◽  
Tubular Damage ◽  
Proximal Tubular ◽  
Proximal Tubular Damage ◽  
Renal Proximal Tubular

scholarly journals Sodium Glucose Co-Transporter 2 Inhibitor Ameliorates Autophagic Flux Impairment on Renal Proximal Tubular Cells in Obesity Mice

2020 ◽  
Vol 21 (11) ◽  
pp. 4054
Author(s):  
Kazuhiko Fukushima ◽  
Shinji Kitamura ◽  
Kenji Tsuji ◽  
Yizhen Sang ◽  
Jun Wada
Keyword(s):  
Renal Injury ◽  
Tubular Damage ◽  
Autophagic Flux ◽  
Protective Effects ◽  
Renal Protection ◽  
Proximal Tubular Cells ◽  
Tubular Cells ◽  
Proximal Tubular ◽  
Renal Proximal Tubular Cells ◽  
Renal Proximal Tubular

Obesity is supposed to cause renal injury via autophagy deficiency. Recently, sodium glucose co-transporter 2 inhibitors (SGLT2i) were reported to protect renal injury. However, the mechanisms of SGLT2i for renal protection are unclear. Here, we investigated the effect of SGLT2i for autophagy in renal proximal tubular cells (PTCs) on obesity mice. We fed C57BL/6J mice with a normal diet (ND) or high-fat and -sugar diet (HFSD) for nine weeks, then administered SGLT2i, empagliflozin, or control compound for one week. Each group contained N = 5. The urinary N-acetyl-beta-d-glucosaminidase level in the HFSD group significantly increased compared to ND group. The tubular damage was suppressed in the SGLT2i–HFSD group. In electron microscopic analysis, multi lamellar bodies that increased in autophagy deficiency were increased in PTCs in the HFSD group but significantly suppressed in the SGLT2i group. The autophagosomes of damaged mitochondria in PTCs in the HFSD group frequently appeared in the SGLT2i group. p62 accumulations in PTCs were significantly increased in HFSD group but significantly suppressed by SGLT2i. In addition, the mammalian target of rapamycin was activated in the HFSD group but significantly suppressed in SGLT2i group. These data suggest that SGLT2i has renal protective effects against obesity via improving autophagy flux impairment in PTCs on a HFSD.

Some Aspects of Nephrotoxicity of Paracetamol and Ketoprofen in Patients with Rheumathoid Arthritis

2016 ◽  
Vol 70 (3) ◽  
pp. 118-124
Author(s):  
Dejan Spasovski ◽  
Sonja Genadieva-Stavric ◽  
Tatjana Sotirova
Keyword(s):  
Colorimetric Method ◽  
Initial Therapy ◽  
Tubular Damage ◽  
Moderate Correlation ◽  
Time Intervals ◽  
Number Of Patients ◽  
Proximal Tubular ◽  
Proximal Tubular Damage

Abstract Introduction. To determine the effect of initial therapy with Paracetamol and Ketoprofen on glomerular and tubular integrity in rheumatoid arthritis (RA), to quantify nephrotoxicity of these two drugs by measurement of enzymuria, which correlates with the damage of tubular epithelium. Microalbuminuria is used as a marker for glomerular damage, and urine excretion of N-Acetyl-b-D-glucosaminidase (NAG) as an indicator of proximal tubular damage. Methods. Using colorimetric method for determination of NAG, and immunoturbidimetric method for microalbuminuria, samples of 70 participants were examined (35 RA patients treated with Paracetamol only, 35 RA patients treated with Ketoprofen). The follow-up was in 5 time-intervals in the course of 24 weeks. Results. There was a moderate correlation between NAG and microalbuminuria (r=0.16) in the group of patients treated with Paracetamol only, and a moderate correlation (r=0.28) in the group of patients treated with Ketoprofen. NAG enzymuria in size, by number of patients Registered, and time of appearance, was greater and appeared earlier in the Ketoprofen group compared to the Paracetamol group. Conclusions. Ketoprofen is more potent NAG inductor and provokes greater tubular enzymuria than Paracetamol. Results from our study confirm safety in use of Paracetamol and Ketoprofen in everyday clinical practice.

A COMPARISON OF THE EFFECTS OF PROXIMAL AND DISTAL TUBULAR DAMAGE ON THE ACTION OF DESOXYCORTICOSTERONE AND ALDOSTERONE

1957 ◽  
Vol 35 (1) ◽  
pp. 641-644
Author(s):  
T. F. Nicholson
Keyword(s):  
Left Kidney ◽  
Left Renal Artery ◽  
Tubular Damage ◽  
Normal Kidney ◽  
Significant Drop ◽  
Sodium Tartrate ◽  
Left Ureter ◽  
Proximal Tubular ◽  
Proximal Tubular Damage ◽  
Distal Tubules

The proximal tubules of the left kidney in dogs were damaged by the injection of 0.5% racemic sodium tartrate into the left renal artery. In other experiments the distal tubules were damaged by the injection of 0.05% mercuric chloride up the left ureter. In animals with proximal tubular damage, intravenous infusions of desoxycorticosterone or aldosterone which produced a significant drop in sodium excretion from the normal kidney had no effect on the amount of sodium excreted by the damaged kidney. In animals with distal tubular damage the effect of these hormones on the damaged kidney was as great as on the normal kidney.

scholarly journals Urinary excretion of carnitine as a marker of proximal tubular damage associated with platin-based antineoplastic drugs

2009 ◽  
Vol 25 (2) ◽  
pp. 426-433 ◽  
Author(s):  
M. Haschke ◽  
T. Vitins ◽  
S. Lude ◽  
L. Todesco ◽  
K. Novakova ◽  
...  
Keyword(s):  
Urinary Excretion ◽  
Tubular Damage ◽  
Antineoplastic Drugs ◽  
Proximal Tubular ◽  
Proximal Tubular Damage

A COMPARISON OF THE EFFECTS OF PROXIMAL AND DISTAL TUBULAR DAMAGE ON THE ACTION OF DESOXYCORTICOSTERONE AND ALDOSTERONE

1957 ◽  
Vol 35 (8) ◽  
pp. 641-644 ◽  
Author(s):  
T. F. Nicholson
Keyword(s):  
Left Kidney ◽  
Left Renal Artery ◽  
Tubular Damage ◽  
Normal Kidney ◽  
Significant Drop ◽  
Sodium Tartrate ◽  
Left Ureter ◽  
Proximal Tubular ◽  
Proximal Tubular Damage ◽  
Distal Tubules

The proximal tubules of the left kidney in dogs were damaged by the injection of 0.5% racemic sodium tartrate into the left renal artery. In other experiments the distal tubules were damaged by the injection of 0.05% mercuric chloride up the left ureter. In animals with proximal tubular damage, intravenous infusions of desoxycorticosterone or aldosterone which produced a significant drop in sodium excretion from the normal kidney had no effect on the amount of sodium excreted by the damaged kidney. In animals with distal tubular damage the effect of these hormones on the damaged kidney was as great as on the normal kidney.

Longterm treatment of psoriasis using fumaric acid preparations can be associated with severe proximal tubular damage

1999 ◽  
Vol 18 (12) ◽  
pp. 738-739 ◽  
Author(s):  
C Raschka ◽  
H J Koch
Keyword(s):  
Side Effects ◽  
Effective Treatment ◽  
Fumaric Acid ◽  
Renal Damage ◽  
Clinical Laboratory ◽  
Tubular Damage ◽  
Longterm Treatment ◽  
Proximal Tubular ◽  
Proximal Tubular Damage

Fumaric acid preparations are used as longterm and effective treatment of psoriasis. Apart from gastrointestinal, dermatological and hematological side-effects, transient renal damage was observed during treatment with fumaric acid. The case of a 38 year old woman who was treated with fumaric acid (420 mg bid) for 5 years before she complained of fatigue and weakness. According to clinical laboratory she had developed severe proximal tubular damage. Hypophosphatemia, glycosuria and proteinuria persisted although medication was stopped immediately.

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