A COMPARISON OF THE EFFECTS OF PROXIMAL AND DISTAL TUBULAR DAMAGE ON THE ACTION OF DESOXYCORTICOSTERONE AND ALDOSTERONE

1957 ◽  
Vol 35 (8) ◽  
pp. 641-644 ◽  
Author(s):  
T. F. Nicholson
Keyword(s):  
Left Kidney ◽  
Left Renal Artery ◽  
Tubular Damage ◽  
Normal Kidney ◽  
Significant Drop ◽  
Sodium Tartrate ◽  
Left Ureter ◽  
Proximal Tubular ◽  
Proximal Tubular Damage ◽  
Distal Tubules

The proximal tubules of the left kidney in dogs were damaged by the injection of 0.5% racemic sodium tartrate into the left renal artery. In other experiments the distal tubules were damaged by the injection of 0.05% mercuric chloride up the left ureter. In animals with proximal tubular damage, intravenous infusions of desoxycorticosterone or aldosterone which produced a significant drop in sodium excretion from the normal kidney had no effect on the amount of sodium excreted by the damaged kidney. In animals with distal tubular damage the effect of these hormones on the damaged kidney was as great as on the normal kidney.

A COMPARISON OF THE EFFECTS OF PROXIMAL AND DISTAL TUBULAR DAMAGE ON THE ACTION OF DESOXYCORTICOSTERONE AND ALDOSTERONE

1957 ◽  
Vol 35 (1) ◽  
pp. 641-644
Author(s):  
T. F. Nicholson
Keyword(s):  
Left Kidney ◽  
Left Renal Artery ◽  
Tubular Damage ◽  
Normal Kidney ◽  
Significant Drop ◽  
Sodium Tartrate ◽  
Left Ureter ◽  
Proximal Tubular ◽  
Proximal Tubular Damage ◽  
Distal Tubules

The proximal tubules of the left kidney in dogs were damaged by the injection of 0.5% racemic sodium tartrate into the left renal artery. In other experiments the distal tubules were damaged by the injection of 0.05% mercuric chloride up the left ureter. In animals with proximal tubular damage, intravenous infusions of desoxycorticosterone or aldosterone which produced a significant drop in sodium excretion from the normal kidney had no effect on the amount of sodium excreted by the damaged kidney. In animals with distal tubular damage the effect of these hormones on the damaged kidney was as great as on the normal kidney.

New insights into the mechanisms involved in renal proximal tubular damage induced in vitro by ochratoxin A

2004 ◽  
Vol 18 (1) ◽  
pp. 43-49 ◽  
Author(s):  
Alessandra Gennari ◽  
Patricia Pazos ◽  
Monica Boveri ◽  
Robert Callaghan ◽  
Juan Casado ◽  
...  
Keyword(s):  
Ochratoxin A ◽  
Tubular Damage ◽  
Proximal Tubular ◽  
Proximal Tubular Damage ◽  
Renal Proximal Tubular

Some Aspects of Nephrotoxicity of Paracetamol and Ketoprofen in Patients with Rheumathoid Arthritis

2016 ◽  
Vol 70 (3) ◽  
pp. 118-124
Author(s):  
Dejan Spasovski ◽  
Sonja Genadieva-Stavric ◽  
Tatjana Sotirova
Keyword(s):  
Colorimetric Method ◽  
Initial Therapy ◽  
Tubular Damage ◽  
Moderate Correlation ◽  
Time Intervals ◽  
Number Of Patients ◽  
Proximal Tubular ◽  
Proximal Tubular Damage

Abstract Introduction. To determine the effect of initial therapy with Paracetamol and Ketoprofen on glomerular and tubular integrity in rheumatoid arthritis (RA), to quantify nephrotoxicity of these two drugs by measurement of enzymuria, which correlates with the damage of tubular epithelium. Microalbuminuria is used as a marker for glomerular damage, and urine excretion of N-Acetyl-b-D-glucosaminidase (NAG) as an indicator of proximal tubular damage. Methods. Using colorimetric method for determination of NAG, and immunoturbidimetric method for microalbuminuria, samples of 70 participants were examined (35 RA patients treated with Paracetamol only, 35 RA patients treated with Ketoprofen). The follow-up was in 5 time-intervals in the course of 24 weeks. Results. There was a moderate correlation between NAG and microalbuminuria (r=0.16) in the group of patients treated with Paracetamol only, and a moderate correlation (r=0.28) in the group of patients treated with Ketoprofen. NAG enzymuria in size, by number of patients Registered, and time of appearance, was greater and appeared earlier in the Ketoprofen group compared to the Paracetamol group. Conclusions. Ketoprofen is more potent NAG inductor and provokes greater tubular enzymuria than Paracetamol. Results from our study confirm safety in use of Paracetamol and Ketoprofen in everyday clinical practice.

scholarly journals Urinary excretion of carnitine as a marker of proximal tubular damage associated with platin-based antineoplastic drugs

2009 ◽  
Vol 25 (2) ◽  
pp. 426-433 ◽  
Author(s):  
M. Haschke ◽  
T. Vitins ◽  
S. Lude ◽  
L. Todesco ◽  
K. Novakova ◽  
...  
Keyword(s):  
Urinary Excretion ◽  
Tubular Damage ◽  
Antineoplastic Drugs ◽  
Proximal Tubular ◽  
Proximal Tubular Damage

Longterm treatment of psoriasis using fumaric acid preparations can be associated with severe proximal tubular damage

1999 ◽  
Vol 18 (12) ◽  
pp. 738-739 ◽  
Author(s):  
C Raschka ◽  
H J Koch
Keyword(s):  
Side Effects ◽  
Effective Treatment ◽  
Fumaric Acid ◽  
Renal Damage ◽  
Clinical Laboratory ◽  
Tubular Damage ◽  
Longterm Treatment ◽  
Proximal Tubular ◽  
Proximal Tubular Damage

Fumaric acid preparations are used as longterm and effective treatment of psoriasis. Apart from gastrointestinal, dermatological and hematological side-effects, transient renal damage was observed during treatment with fumaric acid. The case of a 38 year old woman who was treated with fumaric acid (420 mg bid) for 5 years before she complained of fatigue and weakness. According to clinical laboratory she had developed severe proximal tubular damage. Hypophosphatemia, glycosuria and proteinuria persisted although medication was stopped immediately.

scholarly journals Proximal Tubular Damage in Cirrhosis

1982 ◽  
Vol 83 (3) ◽  
pp. 725 ◽  
Author(s):  
Mauro Bernardi ◽  
Renata Caudarella ◽  
Franco Trevisani ◽  
Giovanni Gasbarrini
Keyword(s):  
Tubular Damage ◽  
Proximal Tubular ◽  
Proximal Tubular Damage

THE EFFECT OF DAMAGE TO VARIOUS PARTS OF THE RENAL TUBULE ON THE EXCRETION OF PHOSPHATE BY THE DOG'S KIDNEY

1959 ◽  
Vol 37 (1) ◽  
pp. 103-111 ◽  
Author(s):  
T. F. Nicholson ◽  
G. W. Shepherd
Keyword(s):  
Proximal Tubule ◽  
Mercuric Chloride ◽  
Renal Tubule ◽  
Potassium Dichromate ◽  
Left Kidney ◽  
Distal Tubule ◽  
Proximal Tubules ◽  
Sodium Tartrate ◽  
Phosphate Excretion ◽  
Distal Tubules

The first third of the proximal tubules of the left kidney in dogs was damaged by the injection of 2.5 mg% potassium dichromate, the last two thirds by the injection of 0.5% sodium tartrate, and the distal tubules by the retrograde injection up the ureter of 0.05% mercuric chloride. Damage to the first third of the proximal tubule resulted in marked increase in phosphate excretion. Damage to the last two thirds of the proximal tubule had no significant effect on the output of phosphate. When the distal tubule was damaged the excretion of phosphate was greatly reduced. The results indicate that phosphate is reabsorbed in the first third of the proximal tubule and actively excreted by the distal tubule.

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