Nephrotoxic Serum Nephritis in Nude Rats: The Role of Cell-Mediated Immunity

Nephron ◽  
1994 ◽  
Vol 68 (3) ◽  
pp. 360-365 ◽  
Author(s):  
T. Kuroda ◽  
K. Kawasaki ◽  
T. Oite ◽  
M. Arakawa ◽  
F. Shimizu
Keyword(s):  
Cell Mediated Immunity ◽  
Nephrotoxic Serum Nephritis ◽  
Nude Rats

Hypothalamo-pituitary control of the cell-mediated immunity in rat embryos: role of LHRH in regulation of lymphocyte proliferation

2000 ◽  
Vol 47 (1) ◽  
pp. 17-32 ◽  
Author(s):  
L.A Zakharova ◽  
I.V Malyukova ◽  
E.V Proshlyakova ◽  
A.A Potapova ◽  
A.Y Sapronova ◽  
...  
Keyword(s):  
Lymphocyte Proliferation ◽  
Cell Mediated Immunity ◽  
Rat Embryos

Emerging role of mesenchymal stem cells during tuberculosis: The fifth element in cell mediated immunity

Tuberculosis ◽  
2016 ◽  
Vol 101 ◽  
pp. S45-S52 ◽  
Author(s):  
Arshad Khan ◽  
Robert L. Hunter ◽  
Chinnaswamy Jagannath
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Cell Mediated Immunity

scholarly journals Private specificities of H-2K and H-2D loci as possible selective targets for effector lymphocytes in cell-mediated immunity.

1975 ◽  
Vol 141 (1) ◽  
pp. 11-26 ◽  
Author(s):  
B D Brondz ◽  
I K Egorov ◽  
G I Drizlikh
Keyword(s):  
T Lymphocytes ◽  
Target Cells ◽  
Cell Mediated Immunity ◽  
Skin Grafts ◽  
Immune Lymphocytes ◽  
Direct Cytotoxicity ◽  
Cross Absorption ◽  
Private Specificity ◽  
Two Populations

Receptors of effector T lymphocytes of congeneic strains of mice do not recognize public H-2 specificities and react to private H-2 specificities only. This has been established with the use of three tests: direct cytotoxicity assay of immune lymphocytes upon target cells, specific absorption of the lymphocytes on the target cells, and rejection of skin grafts at an accelerated fashion. Immunization with two private H-2 specificities in the system C57BL/10ScSn leads to B10.D2 induces formation of two corresponding populations of effector lymphocytes in unequal proportion: a greater part of them is directed against the private specificity H-2.33 (Kb), while the smaller part is towards H-2.2 (Db) private specificity. These two populations of effector lymphocytes do not overlap, as demonstrated by experiments on their cross-absorption on B10.D2 (R107), B10.D2 (R101), B10.A(2R), and B10.A(5R) target cells, as well as on mixtures of R107 and R101 targets. Following removal of lymphocytes reacting with one of the private H-2 specificities, lymphocytes specific to the other specificity are fully maintained. A mixture of target cells, each bearing one of the two immunizing private specificities, absorbs 100% of the immune lymphocytes and is totally destroyed by them. It is suggested that H-2 antigens are natural complexes of hapten-carrier type, in which the role of hapten is played by public H-2 specifities and that of the carrier determinant by either private H-2 specificities or structures closely linked to them. Various models of steric arrangement of MHC determinants recognized by receptors of effector T lymphocytes are discussed.

The Role of Heme Oxygenase-1 in T Cell-Mediated Immunity: The All Encompassing Enzyme

2008 ◽  
Vol 14 (5) ◽  
pp. 454-464 ◽  
Author(s):  
Z. Xia ◽  
W. Zhong ◽  
J. Meyrowitz ◽  
Z. Zhang
Keyword(s):  
T Cell ◽  
Heme Oxygenase ◽  
Heme Oxygenase 1 ◽  
Cell Mediated Immunity

scholarly journals Nephrotoxic serum nephritis in nude rats: the roles of host immune reactions

2008 ◽  
Vol 84 (1) ◽  
pp. 139-144 ◽  
Author(s):  
T. SATO ◽  
T. OITE ◽  
M. NAGASE ◽  
F. SHIMIZU
Keyword(s):  
Immune Reactions ◽  
Nephrotoxic Serum Nephritis ◽  
Nude Rats

scholarly journals Paracoccidioidomycosis associated with acquired immunodificiency syndrome: report of seven cases

1995 ◽  
Vol 37 (3) ◽  
pp. 261-265 ◽  
Author(s):  
Silvio Alencar Marques ◽  
Luciene de Oliveira Conterno ◽  
Luciana P. Sgarbi ◽  
Aurea Maria P.C. Villagra ◽  
Vania P.G. Sabongi ◽  
...  
Keyword(s):  
Drug Users ◽  
Paracoccidioides Brasiliensis ◽  
Clinical Findings ◽  
Cell Mediated Immunity ◽  
Intravenous Drug Users ◽  
Focal Infection ◽  
Acquired Immunodeficiency ◽  
Immunodeficiency Syndrome ◽  
Syndrome Report

We report the clinical findings and evolution of seven patients (five men and two women), the majority of them intravenous drug users, with paracoccidioidomycosis associated to acquired immunodeficiency syndrome (AIDS). In four of the patients the paracoccidioidomycosis was restricted to the lung and in the three others was generalized with cutaneous involvement. Only two of them had lived recently in rural area, an indication of the possible reactivation of latent focal infection in the other five patients. The recognition of the role of cell-mediated immunity in host defense against Paracoccidioides brasiliensis leds to the prediction of a growing occurrence of the paracoccidioidomycosis-AIDS association in areas that are endemic for these diseases.

scholarly journals Immunity to pathogenic free-living amoebae: role of cell-mediated immunity

1980 ◽  
Vol 29 (2) ◽  
pp. 408-410
Author(s):  
R T Cursons ◽  
T J Brown ◽  
E A Keys ◽  
K M Moriarty ◽  
D Till
Keyword(s):  
Immune System ◽  
Inhibition Test ◽  
Delayed Hypersensitivity ◽  
Cell Mediated Immunity ◽  
Pathogenic Species ◽  
Free Living

The role of cell-mediated immunity in defense against pathogenic free-living amoebae was examined. Both the in vitro macrophage inhibition test and the in vivo delayed hypersensitivity test showed responses to both heterologous and homologous antigens, although homologous systems were the most efficient. It is suggested that exposure to nonpathogenic species of free-living amoebae can stimulate the immune system to be effective against pathogenic species. The significance of cell-mediated immunity as a defense against invasion by pathogenic free-living amoebae is discussed.

scholarly journals The role of intestinal microbiota in the pathophysiology of depression

2018 ◽  
Vol 72 ◽  
pp. 795-805
Author(s):  
Apolonia Stefaniak ◽  
Karolina Janion ◽  
Beata Stanuch
Keyword(s):  
Inflammatory Cytokines ◽  
Intestinal Microbiota ◽  
Pharmacological Therapy ◽  
World Health ◽  
Cell Mediated Immunity ◽  
Inflammatory Conditions ◽  
Current State ◽  
High Prevalence ◽  
Health Organization

Depression is a mental disorder with a high prevalence. According to World Health Organization, it is a frequent cause of disability and the leading cause of suicide, with its risk increasing with age. The disorder is commonly diagnosed in patients with acute or chronic inflammatory conditions. Depression is typically accompanied by weakened T cell-mediated immunity, as well as abnormal secretion of pro- and anti-inflammatory cytokines and the resulting imbalance between them. The current developments in the field include a link established between depression and changes in intestinal microflora, suggested by numerous trials involving animals and also a small number of studies conducted on people. This paper is a review of the publications regarding the role of intestinal microbiota in the pathophysiology of depression found in PubMed and Web of Science repositories. The results of studies published over the last decade confirm the significance of intestinal microbiota for the pathophysiology of depression. One of the ways in which intestinal microbiota may impact the development of depression is the response of the innate immunity system to bacterial lipopolysaccharide (LPS), resulting with the stimulation of pro-inflammatory cytokines. The modifications of gut microflora have also been linked to changes in the hypothalamic- pituitary-adrenal axis, in the metabolism of tryptophan, (which is a serotonin substrate) and in neurotransmitter levels in the brain. Even though the results cited in this review seem promising, our current state of knowledge in this respect remains far from satisfactory, warranting further investigation into the potential of bacteria for supplementing the pharmacological therapy of depression.

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