scholarly journals Renal Cell Carcinoma of the Native Kidney in a Female Renal Allograft Patient without Acquired Cystic Kidney Disease

Nephron ◽  
1992 ◽  
Vol 61 (2) ◽  
pp. 238-239 ◽  
Author(s):  
R. Marcén ◽  
J. Pascual ◽  
P. Serrano ◽  
L. Orofino ◽  
F.J. Burgos ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Kidney Disease ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Renal Allograft ◽  
Cystic Kidney Disease ◽  
Cystic Kidney ◽  
Native Kidney ◽  
Acquired Cystic Kidney Disease

C-JUN ACTIVATION IN ACQUIRED CYSTIC KIDNEY DISEASE AND RENAL CELL CARCINOMA

2005 ◽  
Vol 174 (2) ◽  
pp. 726-730 ◽  
Author(s):  
MOTOTSUGU OYA ◽  
SHUJI MIKAMI ◽  
RYUICHI MIZUNO ◽  
KEN MARUMO ◽  
MAKIO MUKAI ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Kidney Disease ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Cystic Kidney Disease ◽  
Cystic Kidney ◽  
Acquired Cystic Kidney Disease

Renal cell carcinoma and acquired cystic kidney disease after renal transplantation

1990 ◽  
Vol 3 (1) ◽  
pp. 49-49 ◽  
Author(s):  
J. Almirall ◽  
M. J. Ricart ◽  
J. M. Campistol ◽  
J. Vilardell ◽  
F. Openheimer ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Renal Transplantation ◽  
Kidney Disease ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Cystic Kidney Disease ◽  
Cystic Kidney ◽  
Acquired Cystic Kidney Disease

scholarly journals Acquired cystic disease and renal cell carcinoma in hemodialysis patients: A case report on three patients

2015 ◽  
Vol 72 (10) ◽  
pp. 932-936
Author(s):  
Mirjana Mijuskovic ◽  
Novak Milovic ◽  
Bozidar Kovacevic ◽  
Dragan Jovanovic ◽  
Dara Stefanovic ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Case Report ◽  
Kidney Disease ◽  
Renal Disease ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Cystic Kidney Disease ◽  
Cystic Kidney ◽  
Ultrasound Screening ◽  
Acquired Cystic Kidney Disease

Introduction. Renal cell carcinoma (RCC) is derived from renal tubular epithelial cells and represents approximately 3.8% of all malignancies in adults. The incidence of renal cell carcinoma has been growing steadily and ranging from 0.6 to 14.7 for every 100,000 inhabitants. Patients with end-stage renal disease and acquired cystic kidney disease are at increased risk of developing RCC while undergoing dialysis treatment or after renal transplantation. Case report. We presented 3 patients undergoing hemodialysis, with acquired cystic kidney disease accompanied by the development of RCC. In all the patients tumor was asymptomatic and discovered through ultrasound screening in 2 patients and in 1 of the patients by post-surgery pathohistological analysis of the tissue of the kidney excised using nephrectomy. All the three patients had organ-limited disease at the time of the diagnosis and they did not require additional therapy after surgical treatment. During the follow- up after nephrectomy from 6 months to 7 years, local recurrence or metastasis of RCC were not diagnosed. Conclusion. Acquired cystic kidney disease represents a predisposing factor for the development of renal cell carcinoma in dialysis patients and requires regular ultrasound examinations of the abdomen aimed at early diagnosis of malignancies. Prognosis for patients with endstage renal disease and RCC is mostly good because these tumors are usually of indolent course.

Exploring comprehensive glycan profiles of acquired cystic kidney disease associated renal cell carcinoma to establish a new diagnostic biomarker

Impact ◽  
2021 ◽  
Vol 2021 (6) ◽  
pp. 40-42
Author(s):  
Kunio Kawanishi
Keyword(s):  
Renal Cell Carcinoma ◽  
Kidney Disease ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Disease Diagnosis ◽  
Cystic Kidney Disease ◽  
Cystic Kidney ◽  
Major Type ◽  
Acid Modification ◽  
Acquired Cystic Kidney Disease

Acquired cystic kidney disease (ACKD) is characterized by the development of numerous renal cysts. Incidence of ACKD is higher amongst patients on haemodialysis and the longer a patient receives this treatment, the more likely ACKD is to occur. Assistant Professor Kunio Kawanishi, Faculty of Medicine, University of Tsukuba, Japan, is focusing on acquired cystic kidney disease associated renal cell carcinoma (ACD-RCC), which is an unique and major type of RCC in haemodialysis patients. He and his team are investigating comprehensive glycan profiles of ACD-RCC to detect possible biomakers. If a useful biomarker can be discovered, disease diagnosis could be improved and therapeutic targets for treatment could be provided. In his current project, Kawanishi is exploring the significance of sialic acid modification and accumulation of ketodeoxynonulosonic acid (Kdn) in end-stage renal disease (ESRD). He is using different techniques to decipher how Kdn and other sialic acids react and circulate within the human body. Kawanishi linked into the TIA collaborative network, which enabled him to access invaluable samples for next generation sequencing, enabling him to determine mRNA expression and perform glycan analysis with lectin microarray. Currently, the researchers are using mass spectrometry to detect ACD-RCC specific glycostructure for establishing ELISA. Next, the team will identify the lectin and antibody specific to the glycan and its carrier protein.

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