Protection of Renal Function and of Nutritional Status in Uremic Rats by Means of a Low-Protein, Low-Phosphorus Supplemented Diet

Nephron ◽  
1988 ◽  
Vol 49 (3) ◽  
pp. 197-202 ◽  
Author(s):  
G. Barsotti ◽  
L. Moriconi ◽  
A. Cupisti ◽  
L. Dani ◽  
F. Ciardella ◽  
...  
Keyword(s):  
Renal Function ◽  
Nutritional Status ◽  
Low Protein ◽  
Low Phosphorus

LOW PROTEIN DIET IN THE MANAGEMENT OF CHRONIC KIDNEY DISEASE IMPROVES NUTRITIONAL STATUS AND RENAL FUNCTION

Nutrition ◽  
2019 ◽  
Vol 65 ◽  
pp. 7
Author(s):  
S. Lamacchia ◽  
N. Regano ◽  
S. Mazzuoli ◽  
I.A. Amerotti ◽  
S.F. Rizzi ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Renal Function ◽  
Kidney Disease ◽  
Nutritional Status ◽  
Protein Diet ◽  
Low Protein Diet ◽  
Low Protein

scholarly journals P1576THE EFFECT OF CHANGING DIETARY PHOSPHORUS-PROTEIN RATIO ON NUTRITIONAL STATUS OF HEMODIALYSIS PATIENTS

2020 ◽  
Vol 35 (Supplement_3) ◽  
Author(s):  
Song Wang ◽  
Xinkui Tian ◽  
Xinhong Lu ◽  
Hanmin Liu ◽  
YUE WANG
Keyword(s):  
Nutritional Status ◽  
Serum Albumin ◽  
Hemodialysis Patients ◽  
Serum Phosphorus ◽  
Maintenance Hemodialysis ◽  
Protein Ratio ◽  
Low Protein ◽  
Dietary Phosphorus ◽  
Low Phosphorus ◽  
Staple Foods

Abstract Background and Aims To investigate the effect of changing dietary phosphorus-protein ratio on the nutritional status of maintenance hemodialysis patients. Method Hemodialysis patients who had average serum phosphorus ≥1.78 mmol/L for three consecutive months were enrolled in this self-controlled trial. Patients received low phosphorus diet instruction for 4 weeks as baseline, followed by changed the diet of staple foods with the same amount of low protein rice for 10 weeks. The difference of protein intake between the low protein rice and staple foods was replaced by low phosphorus whey. Then the patients reverted to staple food for 8 weeks. Serum phosphorus, albumin and nutritional status before and after dietary changes were observed and analyzed. Results 29 patients completed the study. At baseline dietary phosphorus-protein ratio was (15.85±3.29) mg/g, and serum phosphorus was (2.05±0.32) mmol/L. After switch to low protein rice and low phosphorus whey for 10 weeks, dietary phosphorus-protein ratio decreased to (12.18±2.45) mg/g (p<0.001). Simultaneously serum phosphorus decreased to (1.87±0.44) mmol/L (p=0.048). Nutritional status evaluation showed the patients’ serum albumin increased significantly compared with baseline (42.29±3.51 vs. 39.84±3.23 g/L, p<0.001), as well as dry body weight (65.09±15.30 vs. 64.71 ± 15.07 kg, p=0.030), upper arm muscle circumference (22.57±2.83 vs 22.00±3.03 cm, p=0.013), and the grip strength (27.89±7.82 vs. 26.54±7.90 kg, p=0.032). Subjective global assessment (SGA) and serum lipid level did not change significantly after the food change. Conclusion For hemodialysis patients, changing dietary phosphorus-protein ratio by combination of low protein rice and low phosphorus whey could effectively decrease serum phosphorus level, and improve serum albumin, as well as muscle mass and muscle strength.

scholarly journals P0657CHANGES IN CREATININE MAY NO REFLECT MEASURED RENAL FUNCTION CHANGES IN PREDIALYSIS

2020 ◽  
Vol 35 (Supplement_3) ◽  
Author(s):  
Escamilla Cabrera Beatriz ◽  
Nuria Victoria Sánchez Dorta ◽  
Natalia Negrã­n Mena ◽  
Sergio Luis-Lima ◽  
Federico Gonzalez Rinne ◽  
...  
Keyword(s):  
Renal Function ◽  
Clinical Practice ◽  
Nutritional Status ◽  
Serum Creatinine ◽  
Outpatient Clinic ◽  
Intestinal Secretion ◽  
Repeated Measurement ◽  
Clinical Evolution ◽  
Measured Gfr

Abstract Background and Aims Serum creatinine is the most used biomarker of renal function in clinical practice. However, the correlation between creatinine and measured GFR is poor with a variability as wide as 200%. The causes of this phenomena are not clear. Some studies observed tubular handling (reabsorption and secretion) as well as intestinal secretion of creatinine, and depends of nutritional status . Importantly, these changes increased with the loss of renal function, masking changes in the evolution of real renal function. However, scarce evidence is available about the reliability of creatinine in reflecting the changes of renal function over the time in predialysis patients, compared to measured GFR. This information is relevant in the setting of clinical decisions. Method Spanish unicenter study developed at the Hospital Universitario de Canarias (Tenerife). In the pre-dialysis outpatient clinic, subjects are followed with measured GFR (clearance of iohexol by DBS). Measured GFR is performed at baseline and repeated as suggested by the clinical evolution. For this study we included all patients with repeated determinations of creatinine and measured GFR. The changes of creatinine in terms of increase (>10%), decrease (<10%) and stability (±10%) were compared with the changes in measured GFR. Results 89 cases with repeated measurement of GFR and creatinine were evaluated. In 61 cases (68.53%) discrepancies between changes in creatinine and measured GFR were evident. Graphic 1 shows differents discordancing cases with 39 cases (43.8%) overestimation, 7 (7.8%) of infraestimation and 15 cases (24.7%) not change of mGFR with changes on Cr. Conclusion Changes in creatinine do not reflect real changes in real renal function in about 70% of the cases. Whenever possible, the measurement of GFR by whichever method available should be considered in the renal care and follow-up of these patients.

scholarly journals Nutritional status, hyperkalaemia and attainment of energy/protein intake targets in haemodialysis patients following plant-based diets: a longitudinal cohort study

2020 ◽  
Author(s):  
Ailema González-Ortiz ◽  
Hong Xu ◽  
Samuel Ramos-Acevedo ◽  
Carla M Avesani ◽  
Bengt Lindholm ◽  
...  
Keyword(s):  
Nutritional Status ◽  
Energy Intake ◽  
Serum Potassium ◽  
Protein Intake ◽  
Fruits And Vegetables ◽  
Dietary Assessment ◽  
Healthy Plant ◽  
Low Protein ◽  
Single Centre Study ◽  
Current Guidelines

Abstract Background Patients undergoing haemodialysis (HD) are often discouraged from eating fruits and vegetables because of fears of hyperkalaemia and undernutrition, yet evidence to support these claims is scarce. We here explore the association between adherence to a healthy plant-based diet with serum potassium, surrogates of nutritional status and attainment of energy/protein intake targets in HD patients. Methods We performed an observational single-centre study of stable patients undergoing HD with repeated dietary assessment every 3 months. Patients were provided with personalized nutritional counselling according to current guidelines. The diet was evaluated by 3-day food records and characterized by a healthy plant-based diet score (HPDS), which scores positively the intake of plant foods and negatively animal foods and sugar. The malnutrition inflammation score (MIS) and serum potassium were also assessed at each visit. We used mixed-effects models to evaluate the association of the HPDS with markers of nutritional status, serum potassium levels and attainment of energy/protein intake targets. Results After applying inclusion and exclusion criteria, a total of 150 patients contributing to 470 trimestral observations were included. Their mean age was 42 years [standard deviation (SD) 18] and 59% were women. In multivariable models, a higher HPDS was not associated with serum potassium levels or odds of hyperkalaemia {potassium >5.5 mEq/L; odds ratio [OR] 1.00 [95% confidence interval (CI) 0.94–1.07] per HPDS unit higher}. Patients with a higher HPDS did not differ in terms of energy intake [OR for consuming <30 kcal/kg day 1.05 (95% CI 0.97–1.13)] but were at risk of low protein intake [OR for consuming <1.1 g of protein/kg/day 1.11 (95% CI 1.04–1.19)]. A higher HPDS was associated with a lower MIS, indicating better nutritional status. Conclusions In patients undergoing HD, adherence to a healthy plant-based diet was not associated with serum potassium, hyperkalaemia or differences in energy intake. Although these patients were less likely to reach daily protein intake targets, they appeared to associate with better nutritional status over time.

Reversal of Hyperparathyroidism in Severe Uremics Following Very Low-Protein and Low-Phosphorus Diet

Nephron ◽  
1982 ◽  
Vol 30 (4) ◽  
pp. 310-313 ◽  
Author(s):  
G. Barsotti ◽  
E. Morelli ◽  
A. Guiducci ◽  
F. Ciardella ◽  
A. Giannoni ◽  
...  
Keyword(s):  
Low Protein ◽  
Low Phosphorus

Relationships between Oesophagostomum columbianum infection and the nutritional status of sheep. III. Serum and tissue protein changes

1969 ◽  
Vol 20 (5) ◽  
pp. 965 ◽  
Author(s):  
RJ Bawden
Keyword(s):  
Single Dose ◽  
Nutritional Status ◽  
Serum Protein ◽  
High Protein ◽  
Pathological Features ◽  
Tissue Protein ◽  
Protein Depletion ◽  
Low Protein ◽  
Oesophagostomum Columbianum ◽  
Protein Group

The infection of young sheep with 1500 infective Oesophagostomum columbianum larvae was associated with the development of hypoproteinaemia resulting basically from a hypoalbuminaemia. Hypogammaglobulinaemia and hyperbetaglobulinaemia also developed in the infected animals. The concentration of α-globulin in the serum was not affected by infection. The extent and duration of the pathological features in the serum protein concentrations varied with the plane of nutrition. More severe effects were noted in sheep which had been maintained on a low protein ration and which exhibited severe protein depletion of the liver, spleen, and thymus, than in animals on a high protein ration. Within the low protein group the most severe depressions in serum protein concentrations resulted from infection with small multiple doses of larvae compared with the same total number given in a single dose.

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