Urinary Growth Hormone Excretion in 657 Healthy Children and Adults: Normal Values, Inter- and Intraindividual Variations

1991 ◽  
Vol 36 (5-6) ◽  
pp. 174-182 ◽  
Author(s):  
Katharina Main ◽  
Malou Philips ◽  
Merete Jørgensen° ◽  
Niels Erik Skakkebœk
Keyword(s):  
Growth Hormone ◽  
Normal Values ◽  
Healthy Children ◽  
Hormone Excretion

Growth hormone-releasing activity of growth hormone-releasing peptide-1 (a synthetic heptapeptide) in children and adolescents

1993 ◽  
Vol 129 (5) ◽  
pp. 424-426 ◽  
Author(s):  
Zvi Laron ◽  
Cyril Y Bowers ◽  
Daniel Hirsch ◽  
Antonio Selman Almonte ◽  
Moshe Pelz ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Children And Adolescents ◽  
Normal Values ◽  
Gh Deficiency ◽  
Clinical Applications ◽  
Hormone Deficiency ◽  
Pituitary Hormone ◽  
Pituitary Insufficiency ◽  
Healthy Children ◽  
Plasma Prolactin

The heptapeptide growth hormone-releasing peptide-1 (GHRP-1 ), one of a series of recently synthesized small growth hormone (GH)-releasing peptides, was administered as an iv bolus (1 μg/kg) to 15 (six prepubertal, nine pubertal) short but healthy children and adolescents and to eight juvenile patients with pituitary insufficiency (four with isolated growth hormone deficiency, two with multiple pituitary hormone deficiencies, one with partial GH deficiency and one with GH-releasing hormone (GHRH) deficiency). Eleven out of 23 subjects also underwent an iv GHRH (1–29) test (1 μg/kg). All the healthy children responded with a progressive rise in plasma human GH (hGH) peaking at 15–30 min, with a significantly higher rise (p<0.05) in the pubertal than prepubertal group. The hGH response to GHRH (1–29) in these children was similar or slightly higher. Six hypopituitary patients had no response to either GHRP-1 or GHRH; the patient with partial GH deficiency had a hGH peak of 6.5 μg/l (at 5 min) to GHRP-1 and 9.2 μg/l (at 1 5 min) to GHRH. One patient had no response of hGH to hypoglycemia, clonidine and GHRP-1, but the plasma hGH rose to 10 μg/l after GHRH. Following the GHRP-1 bolus there was a significant (p <0.01) rise in plasma free thyroxine and a decrease of thyrotropin (p <0.01), both in the limits of normal values. There was also a transitory rise of plasma cortisol (p <0.05). Plasma prolactin, luteinizing hormone and follicle-stimulating hormone did not change. It is concluded that GHRP-1 is a potent GH-releasing drug because it acts also when administered orally and has great pharmaceutical and clinical applications.

Short-Term Changes in Urinary Growth Hormone Excretion and Lower Leg Length in Healthy Children

1997 ◽  
Vol 48 (2) ◽  
pp. 72-75 ◽  
Author(s):  
S.F. Ahmed ◽  
S.I. Barnes ◽  
W.H.B. Wallace ◽  
C.J.H. Kelnar
Keyword(s):  
Growth Hormone ◽  
Lower Leg ◽  
Healthy Children ◽  
Leg Length ◽  
Short Term ◽  
Hormone Excretion

scholarly journals Differential Diagnosis of the Short IGF-I-Deficient Child with Apparently Normal Growth Hormone Secretion

2021 ◽  
pp. 1-24
Author(s):  
Jan M. Wit ◽  
Sjoerd D. Joustra ◽  
Monique Losekoot ◽  
Hermine A. van Duyvenvoorde ◽  
Christiaan de Bruin
Keyword(s):  
Growth Hormone ◽  
Differential Diagnosis ◽  
Growth Hormone Secretion ◽  
Normal Growth ◽  
Stimulation Test ◽  
Healthy Children ◽  
Genetic Causes ◽  
Gh Secretion ◽  
Igf I

The current differential diagnosis for a short child with low insulin-like growth factor I (IGF-I) and a normal growth hormone (GH) peak in a GH stimulation test (GHST), after exclusion of acquired causes, includes the following disorders: (1) a decreased spontaneous GH secretion in contrast to a normal stimulated GH peak (“GH neurosecretory dysfunction,” GHND) and (2) genetic conditions with a normal GH sensitivity (e.g., pathogenic variants of <i>GH1</i> or <i>GHSR</i>) and (3) GH insensitivity (GHI). We present a critical appraisal of the concept of GHND and the role of 12- or 24-h GH profiles in the selection of children for GH treatment. The mean 24-h GH concentration in healthy children overlaps with that in those with GH deficiency, indicating that the previously proposed cutoff limit (3.0–3.2 μg/L) is too high. The main advantage of performing a GH profile is that it prevents about 20% of false-positive test results of the GHST, while it also detects a low spontaneous GH secretion in children who would be considered GH sufficient based on a stimulation test. However, due to a considerable burden for patients and the health budget, GH profiles are only used in few centres. Regarding genetic causes, there is good evidence of the existence of Kowarski syndrome (due to <i>GH1</i> variants) but less on the role of <i>GHSR</i> variants. Several genetic causes of (partial) GHI are known (<i>GHR</i>, <i>STAT5B</i>, <i>STAT3</i>, <i>IGF1</i>, <i>IGFALS</i> defects, and Noonan and 3M syndromes), some responding positively to GH therapy. In the final section, we speculate on hypothetical causes.

Nocturnal Urinary Growth Hormone Excretion in Growth Hormone-Deficient Children on and off Growth Hormone Treatment

1995 ◽  
Vol 44 (4) ◽  
pp. 147-151 ◽  
Author(s):  
A.M. Skinner ◽  
P.E. Clayton ◽  
G.M. Addison ◽  
D.A. Price
Keyword(s):  
Growth Hormone ◽  
Growth Hormone Treatment ◽  
Hormone Treatment ◽  
Hormone Excretion

Discordant growth hormone and insulin like growth factor-1 values are associated with an increased mortality over concordant normal values in patients treated for acromegaly

2021 ◽  
Author(s):  
Dayakshi Abeyaratne ◽  
Sonia Kaniuka-Jakubowska ◽  
Zoe Plummer ◽  
Natasha Archer ◽  
Fonseka Chathuranga Lakmal ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Growth Factor ◽  
Normal Values ◽  
Insulin Like Growth Factor

Correlation of Urinary Albumin andβ-2-Microglobulin and Growth Hormone Excretion in Patients with Diabetes Mellitus and Short Stature*

1990 ◽  
Vol 71 (3) ◽  
pp. 611-617 ◽  
Author(s):  
FUPING PAN ◽  
JANET L. STEVENSON ◽  
DAVID L. DONALDSON ◽  
JANET LEVY ◽  
THOMAS WIEGMANN ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Growth Hormone ◽  
Short Stature ◽  
Urinary Albumin ◽  
Patients With Diabetes ◽  
Hormone Excretion
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