Ovine Corticotropin-Releasing Hormone Stimulation Test in Patients with Chronic Renal Failure: Pharmacokinetic Properties, and Plasma Adrenocorticotropic Hormone and Serum Cortisol Responses

1988 ◽  
Vol 30 (1) ◽  
pp. 17-21 ◽  
Author(s):  
K.C. Siamopoulos ◽  
E.G. Eleftheriades ◽  
M. Pappas ◽  
G. Sferopoulos ◽  
O. Tsolas
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Adrenocorticotropic Hormone ◽  
Serum Cortisol ◽  
Stimulation Test ◽  
Corticotropin Releasing Hormone ◽  
Releasing Hormone ◽  
Hormone Stimulation ◽  
Pharmacokinetic Properties ◽  
Cortisol Responses

Ovine Corticotropin-Releasing Hormone Stimulation Test in Normal Children

1986 ◽  
Vol 62 (2) ◽  
pp. 390-392 ◽  
Author(s):  
JUDITH LEVINE ROSS ◽  
HEINRICH M. SCHULTE ◽  
WILLIAM T. GALLUCCI ◽  
GORDON B. CUTLER ◽  
D. LYNN LORIAUX ◽  
...  
Keyword(s):  
Stimulation Test ◽  
Corticotropin Releasing Hormone ◽  
Normal Children ◽  
Releasing Hormone ◽  
Hormone Stimulation

Plasma levels of corticotropin-releasing hormone in hypothalamic—pituitary—adrenal disorders and chronic renal failure

1993 ◽  
Vol 128 (6) ◽  
pp. 503-507 ◽  
Author(s):  
Kozo Hashimoto ◽  
Tatsuya Nishioka ◽  
Yukiko Numata ◽  
Takashi Ogasa ◽  
Jingo Kageyama ◽  
...  
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Plasma Levels ◽  
High Performance ◽  
High Plasma ◽  
Reversed Phase ◽  
Corticotropin Releasing Hormone ◽  
Hypothalamic Pituitary Adrenal ◽  
Releasing Hormone ◽  
The Mean

Plasma levels of corticotropin-releasing hormone (CRH) were measured in hypothalamic-pituitary-adrenal disorders and chronic renal failure to investigate the clinical significance of plasma CRH. The mean plasma CRH level in normal subjects (N=26) was 1.64±0.43 pmol/l (normal range 0.77–2.5 pmol/l). Four of six patients with hypothalamic disorders receiving hydrocortisone supplementation had a low plasma CRH level. Two of six patients with Sheehan's syndrome had a low plasma CRH level whereas one patient had a high plasma CRH level. Two patients with Cushing's syndrome had a low plasma CRH level whereas two patients with Cushing's disease had a normal plasma CRH level. Six of 19 patients receiving prednisolone therapy had a low plasma CRH level. The mean plasma CRH level in this group was 0.97±0.34 pmol/l, which is significantly lower than that in the normal group. In this group, significant correlation was seen between plasma CRH and adrenocorticotropin levels. Eleven of 21 patients with chronic renal failure undergoing hemodialysis had a high plasma CRH level. Just after hemodialysis the plasma CRH levels decreased in 15 of 20 patients, while plasma adrenocorticotropin and cortisol levels increased in 13 of 19 patients and in 15 of 20 patients, respectively. Immunoreactive CRH in plasma measured both before and after hemodialysis eluted similarly on reversed-phase high-performance liquid chromatography. These results suggest that the plasma CRH level is at least partially suppressed by a chronically elevated plasma glucocorticoid level and that CRH in plasma is partially removed by hemodialysis.

Sign in / Sign up

Export Citation Format

Share Document