Laser Doppler Perfusion Imaging – A New Technique for Measuring Breast Skin Blood Flow

1995 ◽  
Vol 15 (3) ◽  
pp. 125-130 ◽  
Author(s):  
A.M. Seifalian ◽  
K. Chaloupka ◽  
S.P. Parbhoo
Rheumatology ◽  
1993 ◽  
Vol 32 (10) ◽  
pp. 938-938 ◽  
Author(s):  
A. M. SEIFALIAN ◽  
K. HOWELL ◽  
G. STANSBY ◽  
A. E. JACKSON ◽  
G. HAMILTON ◽  
...  

2009 ◽  
Vol 36 (10) ◽  
pp. 2257-2263 ◽  
Author(s):  
EDOARDO ROSATO ◽  
FEDERICA BORGHESE ◽  
SIMONETTA PISARRI ◽  
FELICE SALSANO

Objective.To investigate capillary morphology and skin blood flow of dorsal hands by nailfold videocapillaroscopy (NVC) and laser Doppler perfusion imaging (LDPI), respectively, in patients with primary Raynaud’s phenomenon (PRP) and systemic sclerosis (SSc) and to compare the results with those obtained in healthy controls.Methods.The study group consisted of 142 patients with SSc, 88 patients with PRP, and 147 healthy controls. NVC was performed in all the groups examined. In patients with SSc the capillaroscopic pattern was classified as early, active, or late group pattern. A baseline skin blood flow determination of the dorsum of the subject’s hands was acquired through a low-energy 670 nm Lisca Laser Doppler Perfusion Imager.Results.In the healthy controls the perfusion distribution pattern was homogeneous, with a proximal-distal perfusion gradient. In patients with PRP, the perfusion distribution pattern was homogeneous, but the proximal-distal perfusion gradient was absent. Finally, in patients with SSc the perfusion distribution pattern was dyshomogeneous and a proximal-distal gradient was absent. The minimum perfusion, mean perfusion, maximum perfusion, and standard deviation, calculated as variation by means of each measurement site, were significantly different in all the groups examinated.Conclusion.NVC represents the best method to analyze microvascular damage in rheumatic diseases. LDPI improves the evaluation of vascular damage in patients with SSc. The LDPI and the capillaroscopic images fully matched the definition of the various stages of vascular digital damage in SSc.


1996 ◽  
Vol 107 (6) ◽  
pp. 882-886 ◽  
Author(s):  
Neil C. Abbot ◽  
William R. Ferrell ◽  
John C. Lockhart ◽  
J. Graham Lowe

1984 ◽  
Vol 30 (4) ◽  
pp. 225-230 ◽  
Author(s):  
Andrew D. Feld ◽  
Joseph D. Fondacaro ◽  
G. Allen Holloway ◽  
Eugene D. Jacobson

2001 ◽  
Vol 101 (1) ◽  
pp. 59-64 ◽  
Author(s):  
Abram KATZ ◽  
Karin EKBERG ◽  
Bo-Lennart JOHANSSON ◽  
John WAHREN

The purpose of this study was to quantify the extent to which skin blood flow (SBF) responses to application of endothelium-dependent and -independent vasodilating agents differ between Type I diabetic patients and healthy subjects. Patients and matched controls were studied after an overnight fast. SBF was determined with laser Doppler perfusion imaging before and after iontophoresis of acetylcholine (Ach; endothelium-dependent) and sodium nitroprusside (SNP; endothelium-independent). Basal SBF did not differ significantly between groups. Iontophoresis of ACh and SNP increased SBF 20-fold in controls. In the patients, the increases in SBF following iontophoresis of ACh and SNP were reduced by 18% and 19%, respectively, versus controls (P < 0.05 for both). These data demonstrate that Type I diabetic patients have similar diminished SBF responses to iontophoresis of ACh and SNP, which suggests that non-endothelial-dependent factors are primarily responsible for the diminished SBF responses.


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