Effect of Ovariectomy and Estradiol Benzoate Treatment on LH-RH Induced LH and FSH Release in the Female Rabbit

1975 ◽  
Vol 6 (5-6) ◽  
pp. 372-379 ◽  
Author(s):  
L. Dufy-Barbe ◽  
P. Franchimont ◽  
B. Dufy ◽  
J.D. Vincent
Keyword(s):  
Estradiol Benzoate ◽  
Female Rabbit ◽  
Lh Rh

The Effect of Estradiol Benzoate on the Pituitary Responsiveness to LH-RH in Male and Female Rats

1974 ◽  
Vol 15 (3-4) ◽  
pp. 182-188 ◽  
Author(s):  
J.A.M.J. van Dieten ◽  
J. Steijsiger ◽  
J. Dullaart ◽  
G.P. van Rees
Keyword(s):  
Estradiol Benzoate ◽  
Female Rats ◽  
Male And Female ◽  
Male And Female Rats ◽  
Lh Rh

Effect of estradiol benzoate on the response of pituitary gland to LH-RH

1981 ◽  
Vol 14 (11) ◽  
pp. xxxvii
Author(s):  
H. Maia ◽  
I.C. Barbosa ◽  
E. Tironi ◽  
E.M. Coutinho
Keyword(s):  
Pituitary Gland ◽  
Estradiol Benzoate ◽  
Lh Rh

scholarly journals The effect of LH-RH administration on LH release in the female rabbit

Reproduction ◽  
1979 ◽  
Vol 56 (1) ◽  
pp. 175-180 ◽  
Author(s):  
J. C. Carlson ◽  
D. G. Perrin
Keyword(s):  
Female Rabbit ◽  
Lh Release ◽  
Lh Rh

EFFECT OF 20α-HYDROXYY-4-PREGNEN-3-ONE ON LUTEINIZING HORMONE SECRETION IN THE FEMALE RABBIT

1977 ◽  
Vol 84 (1) ◽  
pp. 45-50 ◽  
Author(s):  
E. V. YoungLai
Keyword(s):  
Luteinizing Hormone ◽  
Hormone Secretion ◽  
Luteinizing Hormone Secretion ◽  
Releasing Hormone ◽  
Female Rabbit ◽  
Oestradiol Benzoate ◽  
Lh Rh ◽  
Lh Releasing Hormone ◽  
Lh Secretion

ABSTRACT Experiments were performed in the rabbit to determine whether 20α-hydroxy-4-pregnen-3-one (20-OHP) can maintain luteinizing hormone (LH) secretion after injections of LH-releasing hormone (LH-RH). Female rabbits were castrated at least 2 weeks prior to investigation. On the day before LH-RH injection they were cannulated and a dose of oestradiol benzoate (OeB), 100 μg/kg, given intramuscularly. LH-RH, 500 ng/kg, was injected as a bolus via the cannula and 20-OHP, 100 μg/kg and 2.5 mg/kg, injected intramuscularly immediately after. Blood was withdrawn at intervals for up to 5½ h after LH-RH injection. LH secretion dropped to pre-stimulation levels within 3 h after LH-RH alone or in combination with 20-OHP. Administration of LH-RH to oestrogen primed intact females also gave a peak of LH which returned to pre-stimulation levels within 3 h. However, mating seemed to maintain LH levels for a greater period of time.

Modification of Pineal Ultrastructure by Exogenous Hormones

1967 ◽  
Vol 25 ◽  
pp. 170-171
Author(s):  
R. A. Turner ◽  
A. E. Rodin ◽  
D. K. Roberts
Keyword(s):  
Electron Microscopy ◽  
Endoplasmic Reticulum ◽  
Rough Endoplasmic Reticulum ◽  
Estradiol Benzoate ◽  
Female Rats ◽  
List Type ◽  
Type Number ◽  
Pregnant Rats ◽  
Gonadal Atrophy ◽  
Pineal Ultrastructure

There have been many reports which establish a relationship between the pineal and sexual structures, including gonadal hypertrophy after pinealectomy, and gonadal atrophy after injection of pineal homogenates or of melatonin. In order to further delineate this relationship the pineals from 5 groups of female rats were studied by electron microscopy:ControlsPregnant ratsAfter 4 weekly injections of 0.1 mg. estradiol benzoate.After 8 daily injections of 150 mcgm. melatonin (pineal hormone).After 8 daily injections of 3 mg. serotonin (melatonin precursor).No ultrastructural differences were evident between the control, and the pregnancy and melatonin groups. However, the estradiol injected animals exhibited a marked increase in the amount and size of rough endoplasmic reticulum within the pineal cells.

Leuprorelinimplantat in der Routineanwendung: Wirksam, sicher und wirtschaftlich

2010 ◽  
Vol 01 (03) ◽  
pp. 139-140
Author(s):  
Luise Mansel
Keyword(s):  
Lh Rh

Mehr als drei Viertel der Prostata-Karzinome sind Testosteron-sensitiv und wachsen primär hormonabhängig. Daher besteht die Standardtherapie in einer Behandlung mit LH-RH-Analoga (synthetische Gonadotropin-Releasing-Hormon-Analoga). Dabei kommt es durch pharmakologische Absenkung des Serumtestosteronspiegels auf Kastrationsniveau (<50 ng/dl) zur Verringerung der Tumorgröße oder zumWachstumsstillstand. Gegenüber der operativen Kastration hat die medikamentöse Hormonsenkung den Vorteil der Reversibilität.

LH-RH TEST IN 100 PATIENTS WITH OVARIAN INSUFFICIENCY

1974 ◽  
Vol 75 (3) ◽  
pp. 428-434 ◽  
Author(s):  
P.-J. Czygan ◽  
M. Breckwoldt ◽  
F. Lehmann ◽  
R. Langefeld ◽  
G. Bettendorf
Keyword(s):  
Intravenous Injection ◽  
Functional State ◽  
Clear Correlation ◽  
Normal Range ◽  
Ovarian Insufficiency ◽  
Lh Rh ◽  
Dose Dependent Increase ◽  
Dose Dependent

ABSTRACT The effect of synthetic LH-RH was studied in 100 patients with various types of ovarian insufficiency by following up the FSH- and LH-levels in plasma. LH-RH was administered in doses of 12.5, 25 and 100 μg as a rapid intravenous injection. The patients were classified according to the endocrine state of the pituitary as evidenced by the urinary gonadotrophin levels. A clear correlation between the functional state of the pituitary and its responsiveness to exogenous LH-RH was demonstrated. Most of the patients with undetectable low urinary gonadotrophin levels failed to respond. The majority of patients with gonadotrophin excretion in the normal range and those with elevated levels reacted with a dose dependent increase in circulating LH. The amount of liberated FSH however was related to the injected dose only in patients with high gonadotrophic excretion. The present study indicates that synthetic LH-RH provides a useful tool in the evaluation of the pitutiary function particularly in patients with low and with undetectable gonadotrophin excretion. The data presented in this paper also demonstrate that the functional state of the pituitary is clearly reflected by the urinary gonadotrophin levels.

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