Effect of Vitamin E Deficiency on Oxidative Metabolism and Antioxidant Enzyme Activity of Macrophages

1990 ◽  
Vol 34 (3) ◽  
pp. 143-146 ◽  
Author(s):  
A.T. Sharmanov ◽  
B.B. Aidarkhanov ◽  
S.M. Kurmangalinov
Keyword(s):  
Enzyme Activity ◽  
Vitamin E ◽  
Antioxidant Enzyme ◽  
Oxidative Metabolism ◽  
Antioxidant Enzyme Activity ◽  
Vitamin E Deficiency

Effect of Hizikia fusiforme Extracts on Antioxidant Enzyme Activity and Vitamin E Concentration in Rats

2011 ◽  
Vol 40 (11) ◽  
pp. 1556-1561 ◽  
Author(s):  
Hyang-Suk Kim ◽  
Eun-Ok Choi ◽  
Cheol Park ◽  
Yung-Hyun Choi ◽  
Sook-Kyung Hyun ◽  
...  
Keyword(s):  
Enzyme Activity ◽  
Vitamin E ◽  
Antioxidant Enzyme ◽  
Antioxidant Enzyme Activity ◽  
Hizikia Fusiforme

scholarly journals Antioxidant enzyme activity in the muscles of calves depleted of vitamin E or selenium or both

1993 ◽  
Vol 70 (2) ◽  
pp. 621-630 ◽  
Author(s):  
Dominic M. Walsh ◽  
D. Glenn Kennedy ◽  
Edward A. Goodall ◽  
Seamus Kennedy
Keyword(s):  
Enzyme Activity ◽  
Antioxidant Enzymes ◽  
Vitamin E ◽  
Antioxidant Enzyme ◽  
Glutathione Transferase ◽  
Basal Diet ◽  
Antioxidant Enzyme Activity ◽  
Set Up ◽  
Feeding Diets ◽  
Glucose 6 Phosphate Dehydrogenase

Feeding diets depleted of vitamin E and Se to cattle can induce a disease known as nutritional degenerative myopathy. It is believed that an increased peroxidative challenge in muscle is involved in the pathogenesis of this disease. A number of species can up-regulate the activity of some antioxidant enzymes, including glutathione reductase (EC 1.6.4.2), glutathione transferase (EC 2.5.1.18), glucose-6-phosphate dehydrogenase (EC 1.1.1.49), catalase (EC 1.11.1.6), and superoxide dismutase (EC 1.15.1.1), in an attempt to mitigate the effects of a peroxidative challenge. A 2 × 2 factorial study was set up to examine possible changes in the activities of these antioxidant enzymes in muscles of ruminant calves fed on diets low in either vitamin E or Se. Four groups of four calves each were fed on a basal diet of NaOH-treated barley which was supplemented with α-tocopherol or Se or both for a total of 50 weeks. Calves fed on diets depleted of vitamin E, but not those ted on diets low in Se, developed subclinical myopathy, as judged by increases in the activity of plasma creatine kinase (EC 2.7.3.2), and had increased muscle concentrations of two indices of lipid peroxidation, namely thiobarbituric acidreactive substances, with and without ascorbate activation. Feeding diets depleted of vitamin E and diets low in Se both increased muscle activities of glucose-6-phosphate dehydregenase in heart, biceps and supraspinatus. This change may have occurred in an attempt to maintain intracellular pools of reduced glutathione. No other changes in antioxidant enzyme activity were observed.

scholarly journals The effect of consecutive days of exercise on markers of oxidative stress

2007 ◽  
Vol 32 (4) ◽  
pp. 677-685 ◽  
Author(s):  
Cecilia M. Shing ◽  
Jonathan M. Peake ◽  
Shannon M. Ahern ◽  
Natalie A. Strobel ◽  
Gary Wilson ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Enzyme Activity ◽  
Vitamin E ◽  
Antioxidant Enzyme ◽  
High Intensity ◽  
Submaximal Exercise ◽  
Antioxidant Enzyme Activity ◽  
Post Exercise ◽  
Markers Of Oxidative Stress

We examined the influence of 3 consecutive days of high-intensity cycling on blood and urinary markers of oxidative stress. Eight highly-trained male cyclists (VO2 max76 ± 4 mL·kg–1·min–1; mean ± SD) completed an interval session (9 exercise bouts lasting 30 s each, at 150% peak power output) on day 1, followed by 2 laboratory-simulated 30 km time trials on days 2 and 3. The cyclists also completed a submaximal exercise trial matched to the interval session for oxygen consumption. Blood was collected pre- and post-exercise for the determination of malondialdehyde (MDA), total antioxidant status (TAS), vitamin E, and the antioxidant enzyme activity of superoxide dismutase and glutathione peroxidase, while urine was collected for the determination of allantoin. There were significant increases in plasma MDA concentrations (p < 0.01), plasma TAS (p < 0.01), and urinary allantoin excretion (p < 0.01) following the high-intensity interval session on day 1, whereas plasma vitamin E concentration significantly decreased (p = 0.028). Post-exercise changes in plasma MDA (p = 0.036), TAS concentrations (p = 0.039), and urinary allantoin excretion (p = 0.031) were all significantly attenuated over the 3 consecutive days of exercise, whereas resting plasma TAS concentration was elevated. There were no significant changes in plasma MDA, TAS, or allantoin excretion following submaximal exercise and there were no significant changes in antioxidant enzyme activity over consecutive days of exercise or following submaximal exercise. Consecutive days of high-intensity exercise enhanced resting plasma TAS concentration and reduced the post-exercise increase in plasma MDA concentrations.

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