Effects of Gamma-Linolenic Acid Supplementation on Pregnant Rats Fed a Zinc-Deficient Diet

1987 ◽  
Vol 31 (5) ◽  
pp. 312-319 ◽  
Author(s):  
A. Dib ◽  
J.-P. Carreau
Keyword(s):  
Linolenic Acid ◽  
Gamma Linolenic Acid ◽  
Deficient Diet ◽  
Pregnant Rats ◽  
Acid Supplementation ◽  
Zinc Deficient Diet

Zinc deficiency impairs whole body accumulation of polyunsaturates and increases the utilization of [1-14C]linoleate for de novo lipid synthesis in pregnant rats

1995 ◽  
Vol 73 (9) ◽  
pp. 1246-1252 ◽  
Author(s):  
S. C. Cunnane ◽  
J. Yang
Keyword(s):  
Food Intake ◽  
Zinc Deficiency ◽  
De Novo ◽  
Control Diet ◽  
Lipid Synthesis ◽  
Whole Body ◽  
Deficient Diet ◽  
Pregnant Rats ◽  
Whole Body Metabolism ◽  
Zinc Deficient Diet

Zinc deficiency impairs the metabolism of polyunsaturates, but the degree to which its effects are independent of food intake are still in question. Identical amounts of a semiliquid control diet (26.4 mg zinc/kg) or moderately zinc deficient diet (3.2 mg zinc/kg) were tube fed to rats for 11 days during the second half of pregnancy to evaluate the specific effects of zinc deficiency on maternal utilization and fetal accumulation of polyunsaturates. The whole body fatty acid balance method was used to determine net accumulation of polyunsaturates and their whole-body disappearance. Incorporation of 14C from [1-14C]linoleate into maternal and fetal lipid classes was also studied on days 20–21. At term, zinc-deficient rats had significantly higher whole-body disappearance of linoleate and α-linolenate and lower accumulation of n−6 and n−3 long-chain polyunsaturates. Zinc-deficient rats had higher 14C activity in free cholesterol, saturates, and monounsaturates in several maternal organs but not in the fetuses. We conclude that during pregnancy, moderate zinc deficiency not affecting food intake or weight gain still alters whole-body metabolism of linoleate and α-linolenate towards increased β-oxidation and also increases the utilization of carbon from linoleate for de novo lipid synthesis.Key words: cholesterol, linoleate, α-linolenate, oxidation, polyunsaturates, pregnancy, zinc.

Is there a beneficial effect of gamma-linolenic acid supplementation on body fat in postmenopausal hypertensive women? A prospective randomized double-blind placebo-controlled trial

Menopause ◽  
2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Lúcia de Fátima Cahino da Costa Hime ◽  
Ceci Mendes Carvalho Lopes ◽  
Cristiane Lima Roa ◽  
Lea Tami Suzuki Zuchelo ◽  
Edmund C. Baracat ◽  
...  
Keyword(s):  
Beneficial Effect ◽  
Linolenic Acid ◽  
Body Fat ◽  
Controlled Trial ◽  
Gamma Linolenic Acid ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Acid Supplementation

Impact of early dietary gamma-linolenic acid supplementation on atopic eczema in infancy

2006 ◽  
Vol 17 (2) ◽  
pp. 112-117 ◽  
Author(s):  
Richard Kitz ◽  
Markus A. Rose ◽  
Heidrun Schonborn ◽  
Stefan Zielen ◽  
Hans J. Bohles
Keyword(s):  
Linolenic Acid ◽  
Atopic Eczema ◽  
Gamma Linolenic Acid ◽  
Acid Supplementation

Calcium, gamma-linolenic acid and eicosapentaenoic acid supplementation in senile osteoporosis

1998 ◽  
Vol 10 (5) ◽  
pp. 385-394 ◽  
Author(s):  
M. C. Kruger ◽  
H. Coetzer ◽  
R. de Winter ◽  
G. Gericke ◽  
D. H. van Papendorp
Keyword(s):  
Eicosapentaenoic Acid ◽  
Linolenic Acid ◽  
Gamma Linolenic Acid ◽  
Senile Osteoporosis ◽  
Acid Supplementation
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